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| 1 | Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED. | ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu | 2003 | Asian Journal of Andrology2003，5，1： | 38 |
| 2 | Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cells显示文摘 | Fu JD Li J Tweedie D Yu HM Chen L Wang R Riordon DR Brugh SA Wang SQ Boheler KR Yang HT | 2006 | 中国生物学文摘2006，20，7： | 9 |
| 3 | Effect of Nanoparticles on the Performance of Thermally Conductive Epoxy Adhesives显示文摘 | Fu J F Shi L Y Zhang D S | 2010 | Polymer Engineering and Science2010，50，9： | 1 |
| 4 | Characterization of single-walled carbon nanotubes synthesized using iron and cobalt nanoparticles derived from self-assembled diblock copolymer micelles 显示文摘 | Fu Q Reed L Liu J | 2010 | Applied Organometallic Chemistry2010，24，8： | 1 |
| 5 | Assessment of protoxin composition of Bacillus thuringiensis strains by use of polyacrylamide gel block and mass spectrometry显示文摘 | Fu Z J Sun Y J Xia L Q | 2008 | Applied Microbiology and Biotechnology2008，79，5： | 1 |
| 6 | PB/PANI-modified electrode used as a novel oxygen reduction cathode in microbial fuel eell显示文摘 | FU L YOU S J ZHANG GQ | 2011 | Biosens Bioeleetron2011，26，5： | 1 |
| 7 | Cytotoxic T lymphocyte antigen 4 immunoglobu-lin modified dendritic cells attenuate allergic airway inflammation andhyperresponsiveness by regulating the development of T helper type 1(Thl)/Th2 and Th2/regulatory T cell subsets in a murine model of asth-ma显示文摘 | Ying L Fu Z Luo J | 2011 | Clin Exp Immunol2011，165，1： | 1 |
| 8 | The behavioral, digestive and metabolic characteristics of fishes with different foraging strategies 显示文摘 | Fu S J Zeng L Q Li X M | 2009 | The Journal of Experimental Biology2009，212，14： | 1 |
| 9 | Neck circumference positively related with central obesity, overweight, and metabolic syndrome in Chinese subjects with type 2 diabetes: Beijing Community Diabetes Study 4 显示文摘 | Yang G R Yuan S Y Fu H J Wan G Zhu L X Bu X L | 2010 | Diabetes Care2010，33，： | 1 |
| 10 | Improvement of activated sludge dewaterability by mild thermal treatment in CaC12 solution 显示文摘 | Guan B H Yu J Fu H L | 2012 | Water Research2012，46，2： | 1 |
| 11 | The effects of land use on soil moisture variation in the Danangou catchment of the Loess Plateau, China显示文摘 | Fu B J Wang J Chen L D | 2003 | Catena2003，54，12： | 1 |
| 12 | Concentration and mode of occurrence of trace elements in marine oil shale from the Bilong Co area,northern Tibet,China显示文摘 | FU X G WANG J ZENG Y H TAN F W FENG X L | | 0，，01： | 1 |
| 13 | 查看详情显示文摘 | Zhang Y H Fu S Y Li R K Y Wu J T Li L F Ji J H | | 0，，11： | 1 |
| 14 | Relationships between soil characteristics,topography and plant diversity in a heterogeneous deciduous broadleaved forest near Beijing,China显示文摘 | FU B J LIU S L MA K M | 2004 | Plant and Soi12004，261，1： | 1 |
| 15 | Highly Effective Cu-HMS Catalyst for Hydroxylation of Phenol 显示文摘 | Fu Z H Chen J H Yin D L | 2000 | Catalysis Letters2000，66，12： | 1 |
| 16 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 17 | Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice显示文摘 | Fu A L Dong Z H Sun M J | 2006 | Brain Res2006，1109，1： | 1 |
| 18 | Stability analysis of the partial double-layer forms derived from the complete double- layer reticulated dome 显示文摘 | Chen W J He Y L Fu G Y | 2001 | Journal of the International Association for Shell and Spatial Structures2001，42，137： | 1 |
| 19 | Preparation, characterization, and application of modified chitosan sorbents for elemental mercury removal显示文摘 | ZHANG A XIANG J SUN L HU S LI P SHI J FU P SU S | 2009 | Ind Eng Chem Res2009，48，10： | 1 |
| 20 | Research summarization on capsaicin显示文摘 | FengJ N Fu J Han M L | 2005 | Acta Agric Borea Sin2005，14，1： | 1 |
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