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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels显示文摘 | Fu H Li W Lao Y Luo J Lee NT Kan KK Tsang HW Tsim KW Pang Y Li Z Chang DC Li M Han Y | 2006 | 中国生物学文摘2006，20，10： | 10 |
| 3 | 基于选择性激光烧结生物陶瓷复合粉体的工艺研究显示文摘主要研究了复相陶瓷Al2O3-ZrO2-SiO2单层烧结工艺,采用Nd:YAG激光器通过选择性激光烧结(SLS)成型复相陶瓷Al2O3-ZrO2-SiO2,实现了在不添加粘结剂、不作任何后处理的情况下激光束完全熔化样品。采用试验设计法系统地分析了激光烧结各项工艺参数对单层烧结质量的影响。利用SEM、XRD分析了不同工艺参数下单层烧结的显微结构以及对试样性能的影响,并通过试验确定最优工艺参数。而后,分别研究了t-ZrO2相对复合粉体的增韧效果与莫来石对改善零件强度所起的作用,对改善零件整体寿命和可靠性有着重要的意义。 | 王蔚 刘永贤 史向东 盛忠起 FU H Y X J | 2012 | 制造技术与机床2012，，10： | 2 |
| 4 | Hydrogenolysis of glycerol to glycols over ruthenittm catalysts: Effect of support and catalyst reduction temperature 显示文摘 | Feng J Fu H Wang J | 2008 | Catal Commun2008，9，6： | 1 |
| 5 | Genetic analyses and mapping of a new thermo-sensitive genic male sterile gene in maize 显示文摘 | TANG J H FU Z Y HU Y M | 2006 | TherAppl Genet2006，113，： | 1 |
| 6 | Bone tunnel enlargement after anterior cruciate ligament reconstruction:acomparison of hamstring and patellartendon autografts显示文摘 | Hoher J Moller H D Fu F H | 1998 | Knee Surg Sports Traumatol Arthroscopy1998，6，3： | 1 |
| 7 | Functional expression of distinct NMDA channel subunits tagged with green fluorescent protein in hippocampal neurons in culture 显示文摘 | FU Z Y LOSI G | 2002 | Neuropharmacology2002，42，3： | 1 |
| 8 | Functionally graded TiN/TiNi shape memory alloy films显示文摘 | Du H J Zhang S | 2003 | Materials Letters2003，57，6： | 1 |
| 9 | Study on multiplestep incremental air-bending forming of sheet metal with springback model and FEM simulation显示文摘 | Fu Z M Mo J H Zhang W X | 2009 | International Journal of Advanced Manufacturing Technology2009，45，： | 1 |
| 10 | Tanshinone Ⅱ A protects cardiac myoeytes against oxidative stress-triggered damage and apoptosis显示文摘 | Fu J Huang H Du J Pi R Chen J Liu P | 2007 | Eur J Pharmacol2007，568，13： | 1 |
| 11 | Photoelectrochemical property and photocatalytic activity of N-dopod TiO2 nanotube arrays显示文摘 | Xu J J Ao Y H Chen M D Fu D G | 2010 | Applied Surface Science2010，256，13： | 1 |
| 12 | nonsense mutation of the MASS1 gene in a family with febrile and afebrile seizures显示文摘 | Nakayama J Fu Y H Clark A M | 2002 | Ann Neurol2002，52，5： | 1 |
| 13 | A fuzzy neural network for rule acquiring on fuzzy control system显示文摘 | Shann J J Fu H C | 1995 | Fuzzy Sets and Systems1995，71，： | 1 |
| 14 | Monolithic column with zwltterlonlc stationary phase for capillary electrochromatography显示文摘 | FU H J XIE C H DONG J | 2004 | Anal Chem2004，76，： | 1 |
| 15 | Tanshinone ]I A protects car- diac myocytes against oxidative stress-triggered damage and apopto- sis 显示文摘 | Fu J J Huang H W Liu J J | 2007 | Eur J Pharmacol2007，568，123： | 1 |
| 16 | Neck circumference positively related with central obesity, overweight, and metabolic syndrome in Chinese subjects with type 2 diabetes: Beijing Community Diabetes Study 4 显示文摘 | Yang G R Yuan S Y Fu H J Wan G Zhu L X Bu X L | 2010 | Diabetes Care2010，33，： | 1 |
| 17 | Improvement of activated sludge dewaterability by mild thermal treatment in CaC12 solution 显示文摘 | Guan B H Yu J Fu H L | 2012 | Water Research2012，46，2： | 1 |
| 18 | Tanshinone IIA protects cardiac myocytes against oxidative stress-triggered damage and apoptosis显示文摘 | Fu J Huang H Liu J | 2007 | European Journal of Phar- ma-Cology2007，568，13： | 1 |
| 19 | One-pot preparation of poly mer-enzyme metallic nanoparticle composite films for high- performance biosensing of glucose and galactose 显示文摘 | Fu Y C Li P H Xie Q J | 2009 | Adv Funct Mater2009，19，11： | 1 |
| 20 | SiC nanowire-toughened MoSi2-SiC coating to protect carbon/carbon composites a- gainst oxidation 显示文摘 | Fu Q G Li H J Zhang Z Z | 2010 | Corros Sci2010，52，5： | 1 |
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