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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | 质子注入和快速退火对GaAs/AlGaAs量子阱红外探测器的影响显示文摘利用质子注入和快速退火技术改变GaAs/AlGaAs量子阱能级分布,使量子阱红外探测器的光电特性发生变化,在较大地移动了探测波长的同时,探测器的响应率、探测率以及暗电流特性也发生相应变化.在质子注入剂量为2.5×1015cm-2、快速退火条件为950℃、30s时,峰值探测波长移动2μm. | 李娜 陆卫 李宁 刘兴权 袁先漳 窦红飞 沈学础 FU Lan Tan H H C Jagadish M B Johnston M Gal | 2000 | 红外与毫米波学报2000，19，1： | 3 |
| 3 | 伴有浆细胞分化的套细胞淋巴瘤显示文摘 | Young K H Chan W C Fu K 黄文斌(摘译) | 2006 | 临床与实验病理学杂志2006，22，5： | 2 |
| 4 | Handle- aware isolines for scalable shape editing显示文摘 | Au O K C Fu H B Tai C L | 2007 | ACM Transactions on Graphics2007，26，3： | 1 |
| 5 | A review on pharmacological activities and utilization technologies of pumpkin 显示文摘 | Fu C L Shi H Li Q H | 2006 | Plant foods for human nutrition2006，，61： | 1 |
| 6 | A fuzzy neural network for rule acquiring on fuzzy control system显示文摘 | Shann J J Fu H C | 1995 | Fuzzy Sets and Systems1995，71，： | 1 |
| 7 | Monolithic column with zwltterlonlc stationary phase for capillary electrochromatography显示文摘 | FU H J XIE C H DONG J | 2004 | Anal Chem2004，76，： | 1 |
| 8 | One-pot preparation of poly mer-enzyme metallic nanoparticle composite films for high- performance biosensing of glucose and galactose 显示文摘 | Fu Y C Li P H Xie Q J | 2009 | Adv Funct Mater2009，19，11： | 1 |
| 9 | IFN-γ producing T cells contribute to the increase of myeloid derived suppressor ceils in tumor - beating mice after cyclophosphamide treatment 显示文摘 | GUO Q M LV Z C FU Q H | 2012 | International Immunopharmacology2012，，12： | 1 |
| 10 | 14-3-3 proteins:structure,function,and regulation显示文摘 | Fu H Subramanian R R and Masters S C | 2000 | Annu Rev Pharmacol Toxicol2000，40，： | 1 |
| 11 | Electrochemical characteristic of LiMngzMo07s04 (M=Cr, Co) cathode materials synthesized by the microwave-induced combustion method显示文摘 | FU Y P LIN C H SU Y H | 2006 | Journal of Power Sour- ces2006，159，1： | 1 |
| 12 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 13 | Surface modifications of electrode materials for lithium ion batteries显示文摘 | FU L J LIU H LI C WU Y P RAHM E HOLZE R WU H Q | 2006 | Solid State Sci2006，8，2： | 1 |
| 14 | Optimal 3Dstiffener design with fre-quency considerations显示文摘 | Gea H C Fu Y | 1997 | Advances in EngineeringSoftware1997，28，： | 1 |
| 15 | Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors显示文摘 | Daub H Weiss FU Wallasch C | 1996 | Nature1996，379，： | 1 |
| 16 | The gi- ant pandas of the Qinling Mountains, China:a case study in desig- ning conservation landscapes for elevational migrants 显示文摘 | Loucks C J Ltl Z Dinerstein E Wang D J Fu D Wang H | 2003 | Con- servation Biology2003，，17： | 1 |
| 17 | Photocatalytic degradation of RhB by fluorinated Bi2WO6 and distributions of the intermediate products显示文摘 | Fu H B Zhang S C Xu T G | 2008 | Environmental Science & Technology2008，42，6： | 1 |
| 18 | SIRTI prevents atherosclerosis via liverXreceptor and NFkappaB signaling in a U937 cell model 显示文摘 | ZENG H T FU Y C YU W | 2013 | Mol Med Rep2013，8，1： | 1 |
| 19 | Control of a key transition from prostrate to erect growth in rice domestication显示文摘 | Tan L Li X Liu F Sun X Li C Zhu Z Fu Y Cat H Wang X Xie D Sun C | 2008 | Nature Genetics2008，40，11： | 1 |
| 20 | Fabrication,patterning,and optical properties of nanocrystalline YVO4:A(A=Eu3+,Dy3+,Sm3+,Er3+) phosphors films via sol-gel soft lithography显示文摘 | Yu M Lin J Wang Z Fu J Wang S Zhang H J Han J C | | 0，，5： | 1 |
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