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| 1 | Numerical study on ULF waves in a dipole field excited by sudden impulse显示文摘A three-dimensional numerical model is employed to investigate ULF waves ex-cited by the sudden impulse (SI) of the solar wind dynamic pressure interacting with a dipole magnetosphere. We focus on the solar wind-magnetosphere energy coupling through ULF waves, and the influences of the SI spectrum on the cavity mode structure and the energy deposition due to field line resonances (FLRs) in the magnetosphere. The numerical results show that for a given SI lasting for 1 min with amplitude of 50 mV/m impinging on the subsolar magnetopause, the total ULF energy transported from the solar wind to the magnetosphere is about the magni-tude of 1014 J. The efficiency of the solar wind energy input is around 1%, which depends little on the location of the magnetopause in the model. It is also found that the energy of the cavity mode is confined in the region near the magnetopause, whereas, the energy of the toroidal mode may be distributed among a few specific L-shells. With a given size of the model magnetosphere and plasma density distri-bution, it is shown that the fundamental eigenfrequency of the cavity mode and the central locations of the FLRs do not vary noticeably with the power spectrum of the SI. It is worth noting that the spectrum of the SI affects the excitation of higher harmonics of the global cavity mode. The broader the bandwidth of the SI is, the higher harmonics of cavity mode could be excited. Meanwhile, the corresponding FLRs regions are broadened at the same time, which implies that the global cavity modes and toroidal modes can resonate on more magnetic L-shells when more harmonics of the global cavity modes appear. | YANG Biao FU SuiYan ZONG QiuGang WANG YongFu ZHOU XuZhi PU ZuYin XIE Lun | 2008 | Science China(Technological Sciences)2008，51，10： | 12 |
| 2 | Multi-spacecraft observations of ULF waves during the recovery phase of magnetic storm on October 30, 2003显示文摘Based on observations obtained by Cluster C1, GOES 10, 12, and Polar, the global ULF wave properties are studied during the recovery phase of a very intense magnetic storm-Halloween storm (October 31, 2003, 21:00-23:00 UT). The results indicate that the ULF waves’ properties observed by different satellites, such as amplitude, period, etc. show large variations. This can be interpreted as that Field Line Resonance (FLR) might take place in the region where Cluster C1 passed. The compressional wave of the cavity mode coupled with FLR’s shear Alfven wave and fed energy to the latter, forming a large-amplitude toroidal mode. From the point of period, Cluster C1 observed the shortest period, GOES 10, 12 observed the middle, while Polar observed the longest. The wave period of toroidal mode observed by Cluster C1 kept almost unchanging when Cluster C1 passed L range from 11.7 to 5.3. Using the Squared Wavelet Coherence analysis method, we estimated that the FLR region in the dayside magnetosphere could expand to at least 4 local time widths. The toroidal mode observed by Polar was a standing wave, while the pol-oidal mode was a propagating wave, the observation results could be well ex-plained by the waveguide mode theory. Since the solarwind speed Vx was -800 km/s and the dynamic pressure varied little, we speculated that the source of the ULF wave was the Kelvin-Helmholtz instability at the magnetopause triggered by high speed solarwind. | YongFu Wang SuiYan Fu QiuGang Zong Biao Yang ZuYin Pu Lun Xie XuZhi Zhou | 2008 | Science China(Technological Sciences)2008，51，10： | 11 |
| 3 | Impacts of revegetation management modes on soil properties and vegetation ecological restoration in degraded sandy grassland in farming-pastoral ecotone显示文摘Focusing on the impact of various vegetation management modes on sandy grassland's soil property and vegetation ecological restoration of farming-pastoral ecotone,field surveys and lab analysis were conducted to study the correlation between the characteristics of soil properties and vegetation ecological restoration under four different vegetation management modes,i.e.,unenclosed natural restoration,enclosed natural restoration,unenclosed artificial restoration and enclosed artificial restoration,which have a restoration history of 15 years in the southern edge of the degraded sandy land area of Mu Us Desert in Leilongwan Town,Hengshan County,Shaanxi Province.After 15 years of vegetation restoration,these four vegetation management modes all proved to be useful for improving the vegetation ecological restoration and the soil quality of the degraded sandy grassland not only by enhancing the aboveground vegetation height,coverage and biomass but also increasing the content of soil clay,organic matter,CEC,total nitrogen,available nutrient while reducing soil bulk density.The vegetation ecological restoration effect and soil quality under enclosed or artificial restoration management are better than those of unenclosed or natural restoration management;and the most satisfactory vegetation ecological restoration effects and soil quality can be achieved under the integration of enclosed and artificial restoration management.Severely degraded sandy grassland,during the vegetation restoration,would form an interactional coordinating relationship with the vegetation and soil properties.Vegetation properties as height,coverage and biomass have significant positive correlations with organic matter,CEC,total nitrogen and available nitrogen,phosphorus,and potassium contained in soil.Only the adoption of the strict enclosure system,implementation of aggressive artificial vegetation restoration measures and the realization of the regurgitation-feeding policy of industry towards husbandry can guarantee the gradual restoration of degraded sandy grassland in farming-pastoral ecotone,so that it can continue to play the role of ecological protective screen. | Fu Biao Qi Yanbing Chang Qingrui | 2015 | International Journal of Agricultural and Biological Engineering2015，8，1： | 10 |
| 4 | Graphene-encapsulated blackberry-like porous silicon nanospheres prepared by modest magnesiothermic reduction for high-performance lithium-ion battery anode显示文摘Porous silicon(Si)nanostructures have aroused much interest as lithium-ion battery anodes because of the large space to accommodate the volume change in lithiation and delithiation and shorter ion transfer distance.However,fabrication of porous structures tends to be difficult to control and complex,so,the final electrochemical performance can be compromised.Herein,a modest magnesiothermic reduction(MMR)reaction is demonstrated to produce blackberry-like porous Si nanospheres(PSSs)controllably using magnesium silicide(Mg_(2)Si)as Mg source and SiO_(2)nanospheres as the reactant.This improved MR method provides good control of the kinetics and heat release compared to the traditional MR(TMR)method using Mg powder as the reactant.The PSSs obtained by MMR reaction has higher structural integrity than that fabricated by TMR.After encapsulation with reduced graphene oxide,the Si/C composite exhibits superior cycling stability and rates such as a high reversible capacity of 1034 mAh·g^(-1)at0.5 C(4200 mAh·g^(-1)at 1.0 C)after 1000 cycles,capacity retention of 79.5%,and high rate capacity of 497 mAh·g^(-1)at 2.0 C.This strategy offers a new route to fabricate highperformance porous Si anodes and can be extended to other materials such as germanium. | Ben Xiang Wei-Li An Ji-Jiang Fu Shi-Xiong Mei Si-Guang Guo Xu-Ming Zhang Biao Gao Paul K.Chu | 2021 | Rare Metals2021，40，2： | 9 |
| 5 | One-step synthesis of N-doped metal/biochar composite using NH_3-ambiance pyrolysis for efficient degradation and mineralization of Methylene Blue显示文摘A series of new biochar-supported composite based on the combination of biochar and metallic nanoparticles(NPs)were produced through single-step pyrolysis of FeCl_3–Ti(OBu)_4 laden agar biomass under NH_3 environment.The physiochemical properties of composites were characterized thoroughly.It has found that heating temperature and N-doping through NH_3-ambiance pyrolysis significantly influence the visible-light sensitivity and bandgap energy of composites.The catalytic activities of composites were measured by degradation of Methylene Blue(MB)in the presence or absence of H_2O_2 and visible-light irradiation.Our best catalyst(N–TiO_2–Fe_3O_4-biochar)exhibits rapid and high MB removal competency(99.99%)via synergism of adsorption,photodegradation,and Fenton-like reaction.Continuous production of O_2U^-and UOH radicles performs MB degradation and mineralization,confirmed by scavenging experiments and degradation product analysis.The local trap state Ti^(3+),Fe_3O_4,and N-carbon of the catalyst acted as active sites.It has suggested that the Ti^(3+)and N-doped dense carbon layer improve charge separation and shuttle that prolonged photo-Fenton like reaction.Moreover,the catalyst is highly stable,collectible,and recyclable up to 5 cycles with high MB degradation efficiency.This work provides a new insight into the synthesis of highly visible-light sensitized biocharsupported photocatalyst through NH_3-ambiance pyrolysis of NPs-laden biomass. | Md Manik Mian Guijian Liu Balal Yousaf Biao Fu Rafay Ahmed Qumber Abbas Mehr Ahmed Mujtaba Munir Liu Ruijia | 2019 | Journal of Environmental Sciences2019，31，4： | 8 |
| 6 | Grinding behavior and surface appearance of(TiC_p+ TiB_w)/Ti-6Al-4V titanium matrix composites显示文摘(TiCp+ TiBw)/Ti-6Al-4V titanium matrix composites(PTMCs) have broad application prospects in the aviation and nuclear field. However, it is a typical difficult-to-cut material due to high hardness of the reinforcements, high strength and low thermal conductivity of Ti-6Al-4V alloy matrix. Grinding experiments with vitrified CBN wheels were conducted to analyze comparatively the grinding performance of PTMCs and Ti-6Al-4V alloy. Grinding force and force ratios, specific grinding energy, grinding temperature, surface roughness, ground surface appearance were discussed. The results show that the normal grinding force and the force ratios of PTMCs are much larger than that of Ti-6Al-4V alloy. Low depth of cut and high workpiece speed are generally beneficial to achieve the precision ground surface for PTMCs. The hard reinforcements of PTMCs are mainly removed in the ductile mode during grinding. However, the removal phenomenon of the reinforcements due to brittle fracture still exists, which contributes to the lower specific grinding energy and grinding temperature of PTMCs than Ti-6Al-4V alloy. | Ding Wenfeng Zhao Biao Xu Jiuhua Yang Changyong Fu Yucan Su Honghua | 2014 | Chinese Journal of Aeronautics2014，27，5： | 8 |
| 7 | Methodology development and application of X-ray imaging beamline at SSRF显示文摘This paper introduces some latest developments regarding the X-ray imaging methodology and applications of the X-ray imaging and biomedical application beamline(BL13W1)at Shanghai Synchrotron Radiation Facility in the past 5 years.The photon energy range of the beamline is 8–72.5 keV.Several sets of X-ray imaging detectors with different pixel sizes(0.19–24 lm)are used to realize X-ray microcomputed tomography(X-ray micro-CT)and X-ray in-line phase-contrast imaging.To satisfy the requirements of user experiments,new X-ray imaging methods and image processing techniques are developed.In vivo dynamic micro-CT experiments with living insects are performed in 0.5 s(sampling rate of 2 Hz,2 tomograms/s)with a monochromatic beam from a wiggler source and in 40 ms(sampling rate of 25 Hz,25 tomograms/s)with a white beam from a bending magnet source.A new X-ray imaging method known as move contrast X-ray imaging is proposed,with which blood flow and moving tissues in raw images can be distinguished according to their moving frequencies in the time domain.Furthermore,X-ray speckle-tracking imaging with twice exposures to eliminate the edge enhancement effect is developed.A high-precision quantification method is realized to measure complex three-dimensional blood vessels obtained via X-ray micro-CT.X-ray imaging methods such as three-dimensional X-ray diffraction microscopy,small-angle X-ray scattering CT,and X-ray fluorescence CT are developed,in which the X-ray micro-CT imaging method is combined with other contrast mechanisms such as diffraction,scattering,and fluorescence contrasts respectively.Moreover,an X-ray nano-CT experiment is performed with a 100 nm spatial resolution.Typical user experimental results from the fields of material science,biomedicine,paleontology,physics,chemistry,and environmental science obtained on the beamline are provided. | Hong-Lan Xie Biao Deng Guo-Hao Du Ya-Nan Fu Han Guo Yan-Ling Xue Guan-Yun Peng Fen Tao Ling Zhang Ti-Qiao Xiao | 2020 | Nuclear Science and Techniques2020，31，10： | 7 |
| 8 | The genome of Medicago polymorpha provides insights into its edibility and nutritional value as a vegetable and forage legume显示文摘Medicago polymorpha is a nutritious and palatable forage and vegetable plant that also fixes nitrogen.Here,we reveal the chromosome-scale genome sequence of M.polymorpha using an integrated approach including Illumina,PacBio and Hi-C technologies.We combined PacBio full-length RNA-seq,metabolomic analysis,structural anatomy analysis and related physiological indexes to elucidate the important agronomic traits of M.polymorpha for forage and vegetable usage.The assembled M.polymorpha genome consisted of 457.53Mb with a long scaffold N50 of 57.72Mb,and 92.92%(441.83Mb)of the assembly was assigned to seven pseudochromosomes.Comparative genomic analysis revealed that expansion and contraction of the photosynthesis and lignin biosynthetic gene families,respectively,led to enhancement of nutritious compounds and reduced lignin biosynthesis in M.polymorpha.In addition,we found that several positively selected nitrogen metabolism-related genes were responsible for crude protein biosynthesis.Notably,the metabolomic results revealed that a large number of flavonoids,vitamins,alkaloids,and terpenoids were enriched in M.polymorpha.These results imply that the decreased lignin content but relatively high nutrient content of M.polymorpha enhance its edibility and nutritional value as a forage and vegetable.Our genomic data provide a genetic basis that will accelerate functional genomic and breeding research on M.polymorpha as well as other Medicago and legume plants. | Jiawen Cui Zhaogeng Lu Tianyi Wang Gang Chen Salma Mostafa Hailong Ren Sian Liu Chunxiang Fu Li Wang Yingfang Zhu Jinkai Lu Xiang Chen Zhenwu Wei Biao Jin | 2021 | Horticulture Research2021，8，1： | 6 |
| 9 | Regenerative medicine in China:main progress in different fields显示文摘Regenerative medicine(RM) is an emerging interdisciplinary field of research and China has developed the research quickly and impressed the world with numerous research findings in stem cells,tissue engineering,active molecules and gene therapy.Important directions are induced differentiation of induced pluripotent stem and embryo stem cells as well as somatic stem cell differentiation potential and their application in trauma,burns,diseases of aging and nerve regeneration.The products Activ Skin and bone repair scaffolds have been approved and are applied in the clinic,and similar products are being studied.About 10 engineered growth-factor drugs for repair and regeneration have been approved and are used in the clinic.Gene therapy,therapeutic cloning and xenotransplantation are some of the strategies being studied.However,China needs to develop standards,regulations and management practices suitable for the healthy development of RM.Aspects that should be strengthened include sound administrative systems,laws,and technical specifications and guidelines;conservation of stem cell resources;emphasis on training and retention of talented stem cell researchers;and reasonable allocation of resources,diversification of investment and breakthroughs in key areas.Finally,broad and deep international cooperation is necessary. | Biao Cheng Shu-Liang Lu Xiao-Bing Fu | 2016 | Journal of Medical Colleges of PLA(China)2016，31，3： | 5 |
| 10 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 11 | Preparation and evaluation of a new releasable PEGylated tumor necrosis factor-α(TNF-α) conjugate for therapeutic application显示文摘To design a releasable PEGylated TNF-α(rPEG-TNF-α ), a cathepsin B-sensitive dipeptide (Val-Cit moiety) was inserted into conventional PEG-modified TNF- (PEG-TNF- ), facilitating its clinical use for anti-tumor therapy. Comparative pharmaco- kinetic and pharmacodynamic studies showed that the half-lives of both PEGylated forms of TNF-α were ~60-fold greater than that of unmodified TNF-α . In addition, the in vitro bioactivity of rPEG-TNF-α was greater than that of PEG-TNF-α with the same degree of PEG modification. Release of TNF-α from rPEG-TNF-α in vitro was dependent on the presence of cathepsin B and was inhibited by a cathepsin B inhibitor. Despite the potent cytotoxicity of unmodified TNF-α against normal cells, its PEGylated forms at higher TNF-α concentrations showed low cytotoxic activity against these cells. In contrast, both forms of PEGylated TNF-α showed potent cytotoxic activity against the B16 and L929 cell lines, with rPEG-TNF-α being 5- and 9- fold more potent, respectively, than PEG-TNF-α . Moreover, rPEG-TNF-α was a more potent in vivo antitumor agent than PEG-TNF-α . | DAI ChuanYun FU Ya CHEN ShaoCheng LI Biao YAO Bo LIU WanHong ZHU LiQing CHEN Nan CHEN Ji ZHANG Qiang | 2013 | Science China(Life Sciences)2013，56，1： | 4 |
| 12 | Linkage with cathepsin B-sensitive dipeptide promotes the in vitro and in vivo anticancer activity of PEGylated tumor necrosis factor-alpha(TNF-α) against murine fibrosarcoma显示文摘To improve the pharmacological profile of tumor necrosis factor alpha(TNF-α),we have synthesized a new PEGylated prodrug,PEG-vcTNF-α,using a cathepsin B-sensitive dipeptide(valine-citrulline,vc) to link branched PEG and TNF-α.PEG-modified TNF-α without the dipeptide linker(PEG-TNF-α) and unconjugated TNF-α were also tested as controls.It was found for the first time that TNF-α released from PEG-vcTNF-α was specifically dependent on the presence of cathepsin B.PEG-vcTNF-α induced higher cytotoxicity and greater apoptosis against L929 murine fibrosarcoma cells than PEG-TNF-α.Reversal of these effects by a cathepsin-B inhibitor confirmed that these effects were mediated by cathepsin B-specific release of TNF-α.In vivo pharmacokinetics studies demonstrated that the plasma stability of PEG-vcTNF-α was significantly increased compared to TNF-α.Finally,the improved anticancer efficacy of PEG-vcTNF-α and the distinct activities among the three formulations confirmed the positive contribution of both PEGylation and the dipeptide linkage to the improved drug-like properties of PEG-vcTNF-α.The results here indicate that linking proteins and PEG via the cathepsin B-sensitive dipeptide may be a promising strategy for developing protein therapeutics. | DAI ChuanYun FU Ya LI Biao WANG YiGuang ZHANG Xuan WANG JianCheng ZHANG Qiang | 2011 | Science China(Life Sciences)2011，54，2： | 4 |
| 13 | Effect of Intensive Greenhouse Vegetable Cultivation on Selenium Availability in Soil显示文摘Soil properties dramatically change after long-term greenhouse vegetable cultivation, which further affects soil selenium(Se)nutritional status and plant Se uptake. An evaluation of Se availability after long-term greenhouse vegetable cultivation(GVC) can help in better understanding its influential factors under GVC conditions and will also facilitate further regulation of soil Se nutrition in GVC systems. Two typical GVC bases were chosen: one with clayey and acidic soil in Nanjing, southern China, and the other with sandy alkaline soil in Shouguang, northern China. Twenty-seven surface soil samples at the Nanjing base and 61 surface soil samples at the Shouguang base were collected according to cultivation duration and cultivation intensity. Soil properties including soil available Se(PO3-4-Se) and total Se(T-Se) were analyzed. The results showed that soil PO3-4-Se was significantly and negatively correlated with soil Olsen-P, available K(A-K), and electrical conductivity(EC) at the Nanjing base. At the Shouguang base, however, no significant correlation was found between soil PO3-4-Se and Olsen-P and EC, and soil PO3-4-Se increased with increasing soil organic matter(OM). Intensively utilized greenhouse vegetable cultivation caused significant changes in soil properties and further affected soil Se availability. Due to different management practices, the dominant factors affecting Se availability varied between the two GVC bases. At the Nanjing base, the dominant influential factor on soil Se availability was soil nutritional status, especially Olsen-P and A-K status. At the Shouguang base, where organic fertilizers were applied at high rates, soil OM was the dominant influential factor. | FU Ming-Ming HUANG Biao JIA Meng-Meng HU Wen-You SUN Wei-Xia D.C.WEINDORF CHANG Qing | 2015 | Pedosphere2015，25，3： | 4 |
| 14 | Enhanced ion conductivity and electrode–electrolyte interphase stability of porous Si anodes enabled by silicon nitride nanocoating for high-performance Li-ion batteries显示文摘Silicon (Si) is a promising anode material for next-generation high-energy lithium-ion batteries (LIBs) due to its high capacity.However,the large volumetric expansion,poor ion conductivity and unstable solid electrolyte interface (SEI) lead to rapid capacity fading and low rate performance.Herein,we report Si nitride (SiN) comprising stoichiometric Si_(3)N_(4) and Li-active anazotic SiN_(x) coated porous Si (p-Si@SiN)for high-performance anodes in LIBs.The ant-nest-like porous Si consisting of 3D interconnected Si nanoligaments and bicontinuous nanopores prevents pulverization and accommodates volume expansion during cycling.The Si_(3)N_(4) offers mechanically protective coating to endow highly structural integrity and inhibit superfluous formation of SEI.The fast ion conducting Li_(3)N generated in situ from lithiation of active SiN_(x) facilitates Li ion transport.Consequently,the p-Si@SiN anode has appealing electrochemical properties such as a high capacity of 2180 mAh g^(-1)at 0.5 A g^(-1) with 84%capacity retention after 200cycles and excellent rate capacity with discharge capacity of 721 mAh g^(-1) after 500 cycles at 5.0 A g^(-1).This work provides insights into the rational design of active/inactive nanocoating on Si-based anode materials for fast-charging and highly stable LIBs. | Shixiong Mei Siguang Guo Ben Xiang Jiaguo Deng Jijiang Fu Xuming Zhang Yang Zheng Biao Gao Paul K Chu Kaifu Huo | 2022 | Journal of Energy Chemistry2022，31，6： | 2 |
| 15 | Copeptin in the assessment of acute lung injury and cardiogenic pulmonary edema显示文摘 | Qionghua Lin Fengming Fu Haiquan Chen Biao Zhu | 2012 | Respiratory Medicine2012，，9： | 2 |
| 16 | Iatrogenic wounds:a common but often overlooked problem显示文摘Iatrogenic wounds are a common but often overlooked concept.They can lead to increases in hospital stays,therapy costs,repeat surgeries,and implant removal.If not handled properly,these wounds have a very poor prognosis and will cause serious physical and psychological harm to patients,which may result in medicolegal disputes.In recent years,the incidence of iatrogenic wounds has increased because of(1)an increase in the population of older people owing to increased life expectancy,(2)the continued expansion of surgical indications,(3)an increase in difficult surgeries,and(4)the constant emergence and application of new implantable biomaterials and other therapies.Thus,there is a pressing clinical need to improve the therapy of iatrogenic wounds.However,the difficulty in treating these wounds is considerable due to the emergence of drug-resistant bacteria,the high number of patients with metabolic diseases,and complex complications in patients.In particular,iatrogenic wounds caused by surgical site infections due to implantable biomaterials could lead to material leakage and conflicts regarding whether to retain or remove the implants.This review provides a definition of iatrogenic wounds,describes their characteristics,classifies them,and provides information about the importance of analyzing iatrogenic wounds.We hope that this review will provide useful information for the diagnosis and treatment of iatrogenic wounds and help to reduce their incidence in the future. | Biao Cheng Ju Tian Yan Peng Xiaobing Fu | 2019 | Burns & Trauma2019，7，1： | 2 |
| 17 | Compare the epidemiological and clinical features of imported and local COVID-19 cases in Hainan, China显示文摘Background:Effective management of imported cases is an important part of epidemic prevention and control.Hainan Province,China reported 168 coronavirus disease 2019(COVID-19),including 112 imported cases on February 19,2020,but successfully contained the epidemic within 1 month.We described the epidemiological and clinical characteristics of COVID-19 in Hainan and compared these features between imported and local cases to provide information for other international epidemic areas.Methods:We included 91 patients(56 imported and 35 local cases)from two designated hospitals for COVID-19 in Haikou,China,from January 20 to February 19,2020.Data on the demographic,epidemiological,clinical and laboratory characteristics were extracted from medical records.Patients were followed until April 21,2020,and the levels of antibodies at the follow-ups were also analysed by the Wilcoxon matched-pairs signed ranks test.Results:Of the 91 patients,78(85.7%)patients were diagnosed within the first three weeks after the first case was identified(Day 1:Jan 22,2020),while the number of local cases started to increase during the third week No new cases occurred after Day 29.Fever and cough were two main clinical manifestations.In total,15(16.5%)patients were severe,14(15.4%)had complicated infections,nine(9.9%)were admitted to the intensive care unit,and three died.The median duration of viral shedding in feces was longer than that in nasopharyngeal swabs(19 days vs 16 days,P=0.007).Compared with local cases,imported cases were older and had a higher incidence of fever and concurrent infections.There was no difference in outcomes between the two groups.IgG was positive in 92.8%patients(77/83)in the follow-up at week 2 after discharge,while 88.4%patients(38/43)had a reduction in IgG levels in the follow-up at week 4 after discharge,and the median level was lower than that in the follow-up at week 2(10.95 S/Cut Off(S/CO)vs 15.02 S/CO,P<0.001).Conclusion:Imported cases were more severe than local cases but had similar prognoses.The level of IgG antibodies declined from week 6 to week 8 after onset.The short epidemic period in Hainan suggests that the epidemic could be quickly brought under control if proper timely measures were taken. | Biao Wu Zi-Ying Lei Kun-Liang Wu Jian-Rong He Hui-Juan Cao Juan Fu Feng Chen Yuan Chen Bao Chen Xiao-Li Zhou Tao Huang Tao Wu Yong-Guo Du Suo-Xian Chen Fu-Rong Xiao Zhi-Liang Gao Jing He Feng Lin Bing-Liang Lin | 2020 | Infectious Diseases of Poverty2020，9，5： | 2 |
| 18 | Interaction between XRCC1 Polymorphisms and Intake of Long-Term Stored Rice in the Risk of Esophageal Squamous Cell Carcinoma:A Case-Control Study显示文摘Objective This study aimed to explore the roles of three common single nucleotide polymorphisms in the X‐ray repair cross‐complementing group‐1 gene (XRCC1) and of life style factors and their possible interactions in the risk of esophageal squamous cell carcinoma (ESCC) in China.Methods A population‐based case‐control study of 432 cases and 915 controls was conducted in Yangzhong County,Jiangsu Province,China.Subjects were interviewed by trained interviewers using a structured questionnaire that included questions on demographics and life style.XRCC1 genotypes were analyzed using a polymerase chain reaction based restriction fragment length polymorphism (PCR‐RFLP) assay.Unconditional logistic regression analysis was used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for associations of ESCC with XRCC1 polymorphisms and lifestyle‐related factors.Results Both the drinking of river water and alcohol intake history were significantly associated with an increased risk of ESCC among men with aORs of 4.20 (95% CI:2.90‐6.07) and 2.03 (95% CI:1.43‐2.89),respectively.For women,the corresponding odds ratios were 8.37 (95% CI:5.09‐13.75) for river water drinking and 12.78 (95% CI:2.69‐60.69) for long‐term stored rice intake.After the XRCC1 G28152A polymorphism was adjusted for potential confounders,subjects with GA and AA genotypes had an increased risk for ESCC (aOR:1.21,95% CI:0.93‐1.56),compared with subjects with a GG genotype,and a positive multiplicative interaction between intake of long‐term stored rice and the XRCC1 G28152A polymorphism was observed (P=0.009).Conclusions Our findings suggest that both lifestyle‐related factors,including drinking river water,long‐term stored rice and alcohol intake,and the XRCC1 G28152A polymorphism were possible risk factors for ESCC,and that the XRCC1 G28152A polymorphism modified the effect of long‐term stored rice intake on the risk of ESCC among Chinese people. | YU HongJie FU ChaoWei WANG JianMing XUE HengChuan XU Biao | 2011 | Biomedical and Environmental Sciences2011，24，3： | 2 |
| 19 | Deactivation Effect Caused by Catalyst-Cocatalyst Pre-contact in Propylene Polymerization with MgCl2-supported Ziegler-Natta Catalyst显示文摘Propylene slurry polymerization with a MgCl2-supported Ziegler-Natta catalyst containing internal electron donor was conducted after different durations of pre-contact of the catalyst with triethylaluminum cocatalyst. The number of active centers([C*]/[Ti])was determined by quenching the polymerization with 2-thiophenecarbonyl chloride and measuring sulfur content in the polymer. The pre-contact treatment caused selective deactivation of a part of active centers with low stereoselectivity and much lower activity in the initial stage of polymerization as compared with the polymerization run without the pre-contact stage. The active center concentration and polymerization activity decreased with prolonging of the pre-contact stage. The proportion of stereoselective active centers was increased by prolonging the pre-contact stage, so the isotacticity of produced polypropylene was enhanced. Release of active centers through catalyst particle fragmentation was significantly retarded, and the polymerization rate curve changed from decay type to induction type by the precontact treatment. In the induction period both non-stereoselective and stereoselective active centers were released and activated, resulting in gradual reduction of the polymer’s isotacticity in the first 5-10 min of polymerization. Selective deactivation of non-stereoselective active centers also took place in propylene polymerization using the catalyst without pre-contacting with the cocatalyst. In this case, the polymerization rate decayed with time after a short induction period of 2-5 min. Over reduction of the active center precursors with low stereoselectivity by triethylaluminum was considered as the reason for their deactivation during the pre-contact or the polymerization processes. | Zhen Zhang Bai-Yu Jiang Biao Zhang Zhi-Sheng Fu Zhi-Qiang Fan | 2019 | Chinese Journal of Polymer Science2019，37，10： | 2 |
| 20 | Induction of apoptosis in osteosarcoma s180 cells by polysaccharide from dictyophora indusiata显示文摘 | Biao Zhong Yushui Ma Da Fu Chi Zhang | 2013 | Cell Biochem Funct2013，，8： | 1 |
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