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| 1 | Impact of Diabetes on Cardiovascular Disease: An Update显示文摘 | Alessandra Saldanha de Mattos Matheus Lucianne Righeti Monteiro Tannus Roberta Arnoldi Cobas Catia C. Sousa Palma Carlos Antonio Negrato Marilia de Brito Gomes Mario Fritsch Neves | 2013 | International Journal of Hypertension2013，，： | 1 |
| 2 | Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity:state of thescience显示文摘 | Breier JM Gassmann K Kayser R Stegeman H De Groot D Fritsche E | 2010 | Neurotoxicol Teratol2010，32，1： | 1 |
| 3 | Characteristics of burn pa- tients developing pressure ulcers 显示文摘 | Fritsch DE Coffee TL Yowler C J | 2001 | J Burn Care Rehabil2001，22，4： | 1 |
| 4 | RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms显示文摘 | Fritsch R De Krijger I Fritsch K | 2013 | Cell2013，153，5： | 1 |
| 5 | RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms 显示文摘 | Fritsch R de Krijger I Fritsch K | 2013 | Cell2013，153，5： | 1 |
| 6 | Prediction of Extractable Cd,Pb and Zn in Contaminated Woody Habitat Soils Using a Change Point Detection Method显示文摘Accumulation of heavy metals in soils poses a potential risk to plant production, which is related to availability of the metals in soil. The phytoavailability of metals is usually evaluated using extracting solutions such as salts, acids or chelates. The purpose of this study was to identify the most significant soil parameters that can be used to predict the concentrations of acetic and citric acidextractable cadmium(Cd), lead(Pb) and zinc(Zn) in contaminated woody habitat topsoils. Multiple linear regression models were established using two analysis strategies and three sets of variables based on a dataset of 260 soil samples. The performance of these models was evaluated using statistical parameters. Cation exchange capacity, CaCO_3, organic matter, assimilated P, free Al oxide,sand and the total metal concentrations appeared to be the main soil parameters governing the solubility of Cd, Pb and Zn in acetic and citric acid solutions. The results strongly suggest that the metal solubility in extracting solutions is extractable concentrationdependent since models were overall improved by incorporating a change point. This change point detection method was a powerful tool for predicting extractable Cd, Pb and Zn. Suitable predictions of extractable Cd, Pb and Zn concentrations were obtained, with correlation coefficient(adjusted r) ranging from 0.80 to 0.99, given the high complexity of the woody habitat soils studied. Therefore,the predictive models can constitute a decision-making support tool for managing phytoremediation of contaminated soils, making recommendations to control the potential bioavailability of metals. The relationships between acetic and/or citric acid-extractable concentrations and the concentrations of metals into the aboveground parts of plants need to be predicted, in order to make their temporal monitoring easier. | Christophe WATERLOT Christelle PRUVOT Géraldine BIDAR Clémentine FRITSCH Annette DE VAUFLEURY Renaud SCHEIFLER Francis DOUAY | 2016 | Pedosphere2016，26，3： | 1 |
| 7 | Decreased prevalence of celiac disease among Brazilian elderly显示文摘AIM: To evaluate the prevalence of celiac disease in a group of Brazilian individuals over 60 years of age and compare it with the previously known prevalence in a pediatric group living in the same geographical area.METHODS: The research protocol was approved by the Ethics Committee of the University of Brasilia School of Medicine, Brasilia, Brazil. Blood samples from 946 individuals (295 male and 651 female) aged 60 years or older were collected between May 2010 and July 2011. The study subjects' mean and median ages were 68.1 and 67 years, respectively, ranging from 60 to 92 years. That age distribution closely corresponded to the age distribution of the Brazilian population according to the Brazilian 2010 census. The participants were consecutive and unselected outpatients undergoing blood tests at the University of Brasilia Hospital's Clinical Pathology Laboratory. All sera were tested for immunoglobulin A anti-transglutaminase antibodies (IgA-tTG) by enzymelinked immunosorbent assay, and those that were positive were further tested for immunoglobulin A antiendomysium antibodies (IgA-EMA). Human leukocyte antigen (HLA) genotyping was performed for all individuals who exhibited positive serologic results for IgA-tTG and/or IgA-EMA.RESULTS: Out of the 946 studied patients, only one previously diagnosed case of biopsy-proven celiac disease was detected. For the remaining subjects, nine serum samples tested positive for IgA-tTG antibodies; however, none of them tested positive for IgA-EMA antibodies. The HLA genotyping of those nine subjects revealed that one was carrying DQA1*0501 and two were carrying DQB1*0201 alleles. These data showed that, among those 946 elderly individuals, the prevalence of celiac disease (CD) was 0.1% (95%CI: 0.00-0.59). The prevalence of CD for the elderly group was compared with that observed for the group of 2034 children younger than 15 years (age range, 1-14 years; mean age, 8 years) who took part in our previous CD prevalence screening study. All the children came from the same geographical region and shared a similar ethnic and low-income background. As in the elderly group in the current study, the younger group was made up of consecutive outpatients who underwent blood evaluation at the University of Brasilia Hospital's Clinical Laboratory. The prevalence of biopsy-proven CD among those children was 0.54% (95%CI: 0.27-0.57). The comparative analysis between the two groups resulted in the following values: odds ratio = 0.19 (95%CI: 0.01-1.45) Fisher testP = 0.06. CONCLUSION: The prevalence of CD among the children of our previous study was 5.4 times higher than that found in the present elderly group. | Lucas Malta Almeida Luiz Claudio Castro Rosa Harumi Uenishi Fernanda Coutinho de Almeida Patricia Maria Fritsch Lenora Gandolfi Riccardo Pratesi Yanna Karla de Medeiros Nóbrega | 2013 | World Journal of Gastroenterology2013，19，12： | 0 |
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