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| 1 | Portal vein thrombosis in cirrhosis: Controversies and latest developments显示文摘Portal vein thrombosis(PVT) is encountered in livercirrhosis, particularly in advanced disease. It has been a feared complication of cirrhosis, attributed to significant worsening of liver disease, poorer clinical outcomes and potential inoperability at liver transplantation; also catastrophic events such as acute intestinal ischaemia. Optimal management of PVT has not yet been addressed in any consensus publication.We review current literature on PVT in cirrhosis; its prevalence, pathophysiology, diagnosis, impact on the natural history of cirrhosis and liver transplantation,and management. Studies were identified by a search strategy using MEDLINE and Google Scholar. The incidence of PVT increases with increasing severity of liver disease: less than 1% in well-compensated cirrhosis, 7.4%-16% in advanced cirrhosis. Prevalence in patients undergoing liver transplantation is 5%-16%.PVT frequently regresses instead of uniform thrombus progression. PVT is not associated with increased risk of mortality. Optimal management has not been addressed in any consensus publication. We propose areas for future research to address unresolved clinical questions. | Damian J Harding M Thamara PR Perera Frederick Chen Simon Olliff Dhiraj Tripathi | 2015 | World Journal of Gastroenterology2015，21，22： | 42 |
| 2 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 3 | China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design显示文摘 | Rachel P Dreyer Xi Li Xue Du Nicholas S Downing Li Li Hai-Bo Zhang Fang Feng Wen-Chi Guan Xiao Xu Shu-Xia Li Zhen-Qiu Lin Frederick A Masoudi John A Spertus Harlan M Krumholz Li-Xin Jiang | 2016 | Chinese Medical Journal2016，，1： | 13 |
| 4 | 腺嘌呤、嘌呤和四并苯的表面增强拉曼光谱随温度的可逆变化显示文摘用硝酸腐蚀法处理得到了具有表面增强拉曼光谱 (SERS)活性的银表面。在表面温度于 - 1 90℃~30℃变化时 (上升和下降 ) ,分别测定了吸附在银表面上的腺嘌呤、嘌呤和四并苯的表面增强拉曼光谱 ,观察到一系列有关拉曼峰频率和强度的可逆变化。结果表明 ,温度降低 ,吸附分子SERS中受电磁增强机制作用的振动的拉曼位移发生蓝移 ,同时峰强度也有变化 ;而受化学增强机制作用的振动的拉曼位移则不受温度的影响。温度的变化导致分子平面可弯曲分子在金属表面的取向发生变化 ,如腺嘌呤和嘌呤在高温下取直立态 ,而平面的对称分子 (如四并苯 )在表面上的取向则不受温度的影响。 | 瞿金蓉 胡明安 P M Fredericks | 2003 | 光谱学与光谱分析2003，23，1： | 3 |
| 5 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 6 | The prevalence and etiology of elevated aminotransferase levels in the United States显示文摘 | Jeanne M Clark Frederick L Brancati Anna Mae Diehl | 2003 | The American Journal of Gastroenterology2003，，5： | 2 |
| 7 | Differentiation of in situ oxidized and fresh coal using FTIR techniques显示文摘 | FREDERICKS P M MOXON N T | 1986 | Fuel1986，65，11： | 2 |
| 8 | Soil moisture: A central and unifying theme in physical geography显示文摘 | Legates David R Mahmood Rezaul Levia Delphis F DeLiberty Tracy L Quiring Steven M Houser Chris Nelson Frederick E | 2011 | Progress in Physical Geography2011，，1： | 2 |
| 9 | Body image as a leisure con straint :Examining the experience of aerobic exercise classes for young women显示文摘 | FREDERICK C SHAW S M | 1995 | leisure Sci1995，17，2： | 1 |
| 10 | 几种水溶性Porphyrin在电化学处理的银表面上的表面增强拉曼光谱(英文)显示文摘利用波长为632.8nm激光激发的拉曼光谱仪,测定了三种水溶性porphyrin在电化学粗糙银表面上的表面增强拉曼光谱(SERS).这些光谱非常相似,但也有一些重要的差别.实验还表明:当Sn(Ⅳ)TMPyP(4)吸附在Ag表面上时,Sn-N键仍稳定存在,而且吸附分子的表面浓度不同,其在表面的取向也不同. | 瞿金蓉 朱传方 王贤明 Fredericks P M | 2000 | 华中师范大学学报(自然科学版)2000，34，1： | 1 |
| 11 | Safety and immunogenicity of a baculovims-expressed hemagglutinin influenza vaccine: a randomized controlled trial显示文摘 | John J T Gillbert M S Frederick G H | 2007 | JAMA2007，297，14： | 1 |
| 12 | Tacrolimus pharmacogenetics: the CYP3A5*1 allele predicts low dose-normalized tacrolimus blood concentrations in whites and South Asians显示文摘 | MACPHEE IA FREDERICKS S MOHAMED M | 2005 | Transplantation2005，79，： | 1 |
| 13 | The mechanism of the Ter Meer reaction显示文摘 | Hawthorne M Frederick | 1956 | J Am Chem Soc1956，78，19： | 1 |
| 14 | The use of an injectable, biodegradable calcium phosphate bone substitute for the prophylactic augmentation of osteoporotic vertebrae and the management of vertebral compression fractures 显示文摘 | Bo Bai Laith M J Frederick JK | 1999 | Spine1999，24，： | 1 |
| 15 | Optimal Path Planning for UCAV to Defeat Radar Tracking 显示文摘 | Pierre T K Semyou M M Frederick H Z | 2006 | Journal of Guidance Control and Dynamics March-April2006，29，2： | 1 |
| 16 | Risk Factors for hepatic morbidity following nonoperative management显示文摘 | Rosemary A K Frederick A M Clay C | 2006 | Archives of Surgery2006，141，5： | 1 |
| 17 | Finite element analysis of steel girder highway bridges 显示文摘 | Mabsout M E Tarhini K M Frederick G R Tayar C | 2002 | Journal of bridge Engineering2002，7，5： | 1 |
| 18 | Ex- ome sequencing of head and neck squamous cell carcino- ma reveals inactivating mutations in NOTCH1 显示文摘 | Agrawal N Frederick M J Picketing C R | 2011 | Sci- ence2011，333，6046： | 1 |
| 19 | Prevalence and associa tions of 25-hydroxyvitamin D deficiency in US children NHANES 2001- 2004 显示文摘 | Juhi K Paul M Frederick JK | 2009 | Pediatrics2009，124，3： | 1 |
| 20 | Full scale self-propulsion computations using discretized propeller for the kriso eontainer ship KCS 显示文摘 | ALEJANDRO M C PABLO M C FREDERICK S | 2011 | Computers & Fluids2011，51，： | 1 |
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