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| 1 | Intestinal antigen-presenting cells in mucosal immune homeostasis:Crosstalk between dendritic cells,macrophages and B-cells显示文摘The intestinal immune system maintains a delicate balance between immunogenicity against invading pathogens and tolerance of the commensal microbiota.Inflammatory bowel disease(IBD)involves a breakdown in tolerance towards the microbiota.Dendritic cells(DC),macrophages(MΦ)and B-cells are known as professional antigen-presenting cells(APC)due to their specialization in presenting processed antigen to T-cells,and in turn shaping types of T-cell responses generated.Intestinal DC are migratory cells,unique in their ability to generate primary T-cell responses in mesenteric lymph nodes or Peyer’s patches,whilst MΦand B-cells contribute to polarization and differentiation of secondary T-cell responses in the gut lamina propria.The antigen-sampling function of gut DC and MΦenables them to sample bacterial antigens from the gut lumen to determine types of T-cell responses generated.The primary function of intestinal B-cells involves their secretion of large amounts of immunoglobulin A,which in turn contributes to epithelial barrier function and limits immune responses towards to microbiota.Here,we review the role of all three types of APC in intestinal immunity,both in the steady state and in inflammation,and how these cells interact with one another,as well as with the intestinal microenvironment,to shape mucosal immune responses.We describe mechanisms of maintaining intestinal immune tolerance in the steady state but also inappropriate responses of APC to components of the gut microbiota that contribute to pathology in IBD. | Elizabeth R Mann Xuhang Li | 2014 | World Journal of Gastroenterology2014，20，29： | 19 |
| 2 | 溃疡性结肠炎发病的分子机制进展显示文摘以往将溃疡性结肠炎和克罗恩病统称为炎症性肠病(IBD),经过几十年的研究与观察,此两种疾病虽有许多共同点,但在病因学、免疫学、分子机制、病理生理与病理及治疗等方面有许多差异,逐渐倾向于可能为各自独立的疾病。虽然溃疡性结肠炎癌变(不典型增生一癌)发生率比克罗恩病高很多,但前者手术切除结肠有望获得治愈。溃疡性结肠炎发病率高于克罗恩病,为每年1.2-20.3例/10万人,并且其患病率每年7.6-206.0例/10万人。从世界范围看,北欧和北美的人群发病率高,而亚洲地区发病率较低,但我国溃疡性结肠炎发病率有逐年上升趋势,其原因有待探讨。现就溃疡性结肠炎发病的分子机制进展作一阐述。 | 池肇春 | 2012 | 中国医师进修杂志2012，35，19： | 1 |
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