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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Comparison of estimators of variance for forest inventories with systematic sampling-results from artificial populations显示文摘Background:Large area forest inventories often use regular grids(with a single random start)of sample locations to ensure a uniform sampling intensity across the space of the surveyed populations.A design-unbiased estimator of variance does not exist for this design.Oftentimes,a quasi-default estimator applicable to simple random sampling(SRS)is used,even if it carries with it the likely risk of overestimating the variance by a practically important margin.To better exploit the precision of systematic sampling we assess the performance of five estimators of variance,including the quasi default.In this study,simulated systematic sampling was applied to artificial populations with contrasting covariance structures and with or without linear trends.We compared the results obtained with the SRS,Matern’s,successive difference replication,Ripley’s,and D’Orazio’s variance estimators.Results:The variances obtained with the four alternatives to the SRS estimator of variance were strongly correlated,and in all study settings consistently closer to the target design variance than the estimator for SRS.The latter always produced the greatest overestimation.In populations with a near zero spatial autocorrelation,all estimators,performed equally,and delivered estimates close to the actual design variance.Conclusion:Without a linear trend,the SDR and DOR estimators were best with variance estimates more narrowly distributed around the benchmark;yet in terms of the least average absolute deviation,Matern’s estimator held a narrow lead.With a strong or moderate linear trend,Matern’s estimator is choice.In large populations,and a low sampling intensity,the performance of the investigated estimators becomes more similar. | Steen Magnussen Ronald EMcRoberts Johannes Breidenbach Thomas Nord-Larsen Göran Ståhl Lutz Fehrmann Sebastian Schnell | 2020 | Forest Ecosystems2020，7，2： | 2 |
| 3 | Histologic characterization of coblation nucleoplasty performed on sheep intervertebral discs 显示文摘 | Lee Ms Cooper G Lutz GE | 2003 | Pain Physician2003，6，4： | 1 |
| 4 | Formation of mesopores in USY zeolites:a case revisited显示文摘 | LUTZ W KURZHALS R KRYUKOVA G | 2010 | Zeitschrift für Anorganische und Allgemeine Chemie2010，8，： | 1 |
| 5 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 6 | Flattening filter free beams in SBRT and 1MRT: dosimetric assessment of peripheral doses 显示文摘 | KRAGL G BALER F LUTZ S | 2011 | Meal Phys2011，21，2： | 1 |
| 7 | Immature, sem -mature and fully mature dendritic cells: which signals induce tolerance or immunity 显示文摘 | LUTZ M B SCHULER G | 2002 | Trends Immunol2002，23，9： | 1 |
| 8 | Immature, semimature and fully mature dendritic cells: which signals induce tolerance or immunity2 显示文摘 | Lutz MB Schuler G | 2002 | Trends Immunol2002，23，9： | 1 |
| 9 | Structure Refinement of Skutterudite-Type Cobalt Triantimonide, CoSb3 显示文摘 | Schmidt T Kliche G Lutz H D | 1987 | Acta Crystallographica Section C1987，43，： | 1 |
| 10 | Modem trends in polymer bioconjugates design 显示文摘 | Lutz J F Borner H G | 2008 | Progress in Polymer Science2008，33，1： | 1 |
| 11 | Low temperature conversion of some Brazilian municipal and industrial sludges 显示文摘 | Lutz H Romeiro G A Damasceno R N | 2000 | Bioresource Technology2000，74，： | 1 |
| 12 | Gene transcription of neuroglobin is upregulated by hypoxia and anoxia in the brain of the anoxia - tolerant turtle trachemys scripta 显示文摘 | Milton S L Nayak G Lutz P L | 2006 | Bomediacal Sci2006，13，4： | 1 |
| 13 | Natural attenuation of chlorinated solvents at Area 6,Dover Air Force Base:groundwater biogeochemistry显示文摘 | Witt M E Klecka G M Lutz E J | 2002 | Journal of Contaminant Hydrology2002，57，12： | 1 |
| 14 | Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?显示文摘 | Lutz MB Schuler G | 2002 | Trends Immunol2002，23，9： | 1 |
| 15 | 显示文摘 | SIJBESMA R B KENTGENS A P M LUTZ E T G | 1993 | J Am Chem Soc1993，115，20： | 1 |
| 16 | Combining ATRP and 'click' chemistry: A promising platform toward func- tional biocompatible polymers and polymer bioconjugates 显示文摘 | Lutz J F Borner H G Weichenhan K | 2006 | Macromolecules2006，39，19： | 1 |
| 17 | Chiral N-Heterocyclic Carbenes as Stereodirecting Ligands in Asymmetric Catalysis显示文摘 | LUTZ H G STEPHANE B L | 2007 | Topics in Organometal|ic Chemistry2007，21，11： | 1 |
| 18 | Skeletal myosinⅡstructure and function 显示文摘 | Lutz G J Lieber R L | 1999 | Exerc Sport Sci Rev1999，27，： | 1 |
| 19 | Activity of Kal(MoO4)2 and NaAl(MoO4)2显示文摘 | MACZKA M HANUZA J LUTZ E T G | 1999 | J Phys Chem Solids1999，14，2： | 1 |
| 20 | Rare earth element and isotope (C, O, Sr) characteristics of hydrothermal carbonates: genetic implications for dolomite-hosted talc mineralization at G?pfersgrün (Fichtelgebirge, Germany)显示文摘 | Lutz Hecht Regina Freiberger H.Albert Gilg Günter Grundmann Yuri A. Kostitsyn | 1999 | Chemical Geology1999，，1： | 1 |
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