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| 1 | Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia显示文摘Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets. | John M Rosen Jose T Cocjin Jennifer V Schurman Jennifer M Colombo Craig A Friesen | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 16 |
| 2 | Polymorphisms of DNA repair genes XRCC1 and XRCC3, interaction with environmental exposure and risk of chronic gastritis and gastric cancer显示文摘AIM: To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population.METHODS: Genotyping by PCR-RFLP was carried out on 202 patients with chronic gastritis (CG) and 160 patients with gastric cancer (GC), matched to 202 (C1) and 150(C2) controls, respectively.RESULTS: No differences were observed among the studied grou ps with regard to the genotype distribution of XRCC1 codons 194 and 399 and of XRCC3 codon 241. However, the combined analyses of the three variant alleles (194Trp, 399Gln and 241Met) showed an increased risk for chronic gastritis when compared to the GC group. Moreover, an interaction between the polymorphic alleles and demographic and environmental factors was observed in the CG and GC groups. XRCC1 194Trp was associated with smoking in the CG group,while the variant alleles XRCC1 399Gln and XRCC3241Met were related with gender, smoking, drinking and H pylori infection in the CG and GC groups.CONCLUSION: Our results showed no evidence of a rela-tionship between the polymorphisms XRCC1Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk of chronic gastritis and gastric cancer in the Brazilian population, but the combined effect of these variants may interact to increase the risk for chronic gastritis,considered a premalignant lesion. Our data also indicate a gene-environment interaction in the susceptibility to chronic gastritis and gastric cancer. | Márcia Cristina Duarte Jucimara Colombo Andrea Regina Baptista Rossit Alaor Caetano Aldenis Albaneze Borim Durval Wornrath Ana Elizabete Silva | 2005 | World Journal of Gastroenterology2005，11，42： | 11 |
| 3 | Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference显示文摘 | Jordi Bruix Morris Sherman Josep M Llovet Michel Beaugrand Riccardo Lencioni Andrew K Burroughs Erik Christensen Luigi Pagliaro Massimo Colombo Juan Rodés | 2001 | Journal of Hepatology2001，，3： | 11 |
| 4 | 欧洲肿瘤内科协会对新发和复发性卵巢上皮癌的诊断、治疗和随访制定的临床实践指南显示文摘发病率卵巢癌在女性常见癌症中(皮肤癌除外)位列第九,在癌症所致的女性死亡原因中居第五位。女性在一生中患卵巢浸润癌的风险是1/71,而死于卵巢浸润癌的风险是1/95。在美国,据估计每年有21 550例的新发病例,且有14 600人死于卵巢癌。然而,在世界不同地区卵巢癌的发病率大不相同,2004年欧盟国家估计每年新发病例42 700例,而病死率为12/10万。 | Colombo N Peiretti M Parma G Lapresa M Mancari R Carinelli S Sessa C Castiglione M 杨华 郎景和 | 2011 | 国际妇产科学杂志2011，38，3： | 9 |
| 5 | Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia显示文摘There is an increasing appreciation for the importance of inflammation as a pathophysiologic entity that contributes to functional gastrointestinal disorders including functional dyspepsia(FD).Importantly,inflammation may serve as a mediator between psychologic and physiologic functions.This manuscript reviews the literature implicating two inflammatory cell types,mast cells and eosinophils,in the generation of dyspeptic symptoms and explores their potential as targets for the treatment of FD.There are a number of inciting events which may initiate an inflammatory response,and the subsequent recruitment and activation of mast cells and eosinophils.These include internal triggers such as stress and anxiety,as well as external triggers such as microbes and allergens.Previous studies suggest that there may be efficacy in utilizing medications directed at mast cells and eosinophils.Evidence exists to suggest that combining 'anti-inflammatory' medications with other treatments targeting stress can improve the rate of symptom resolution in pediatric FD. | Craig A Friesen Jennifer V Schurman Jennifer M Colombo Susan M Abdel-Rahman | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，4： | 4 |
| 6 | ABT-450, Ritonavir, Ombitasvir, and Dasabuvir Achieves 97% and 100% Sustained Virologic Response With or Without Ribavirin in Treatment-experienced Patients with HCV Genotype 1b Infection显示文摘 | Pietro Andreone Massimo G. Colombo Jeffrey V. Enejosa Iftihar Koksal Peter Ferenci Andreas Maieron Beat Müllhaupt Yves Horsmans Ola Weiland Henk W. Reesink Lino Rodrigues Yiran B. Hu Thomas Podsadecki Barry Bernstein | 2014 | Gastroenterology2014，，： | 2 |
| 7 | Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Friedrich W Mohr Marie-Claude Morice A Pieter Kappetein Ted E Feldman Elisabeth St?hle Antonio Colombo Michael J Mack David R Holmes Marie-angèle Morel Nic Van Dyck Vicki M Houle Keith D Dawkins Patrick W Serruys | 2013 | The Lancet . 2013 (9867)2013，，9867： | 2 |
| 8 | Electroclinical, MRI and neuropathological study of 10 patients with nodular heterotopia, with surgical outcomes 显示文摘 | Tassi L Colombo N Cossu M | 2005 | Brain2005，128，2： | 1 |
| 9 | Antimony tri- oxide-induced apoptosis is dependent on SEKI/JNK sig- naling 显示文摘 | MANN K K DAVISON K COLOMBO M | 2006 | Toxicology letters2006，160，1： | 1 |
| 10 | Hy-drocarbons in coastal sediments of Patagonia,Argentina:Levelsand probable sources显示文摘 | COMMENDATORE M G ESTEVES J L COLOMBOS J C | 2000 | Marine Pollution Bulletin2000，40，： | 1 |
| 11 | Geophysical modeling via simultaneous joint inversion of seismic, gravity, and electro-magnetic data: Application to prestack depth imaging 显示文摘 | Colombo D Stefano M D | 2007 | The Leading Edge2007，26，3： | 1 |
| 12 | An update on vitamin E, tocopherol and tocotrienol- perspectives 显示文摘 | Colombo M L | 2010 | Molecules2010，15，： | 1 |
| 13 | Antidiabetic therapy in real practice: indicators for adherence and treatment cost显示文摘 | Colombo GL Rossi E De Rosa M | 2012 | Patient Prefer Adherence2012，6，： | 1 |
| 14 | Screening and diagnosis of hepatocellular carcinoma显示文摘 | Colombo M | 2009 | Liver Int2009，29，1： | 1 |
| 15 | Assessment of greenhouse gas mitigation options and costs for california petroleum industry facilities: the shape of things to come显示文摘 | NORDRUM S LIEBERMAN D COLOMBO M | 2011 | Energy Procedia2011，4，： | 1 |
| 16 | Isolation of endophytic fungi and actinomycetes taxane producers显示文摘 | Colombo AL Fedeli L | 2000 | Ann Microbiol2000，50，1： | 1 |
| 17 | Cutting balloon angioplasty for the treatment of in-stent restenosis:a matched comparison with rotational atherectomy,additional stent implantation and balloon angioplasty显示文摘 | ADAMIAN M COLOMBO A BRIGUORI C | 2001 | J Am Coll Cardiol2001，38，： | 1 |
| 18 | Computerized visual feedback:an adjunct to robotic-assisted gait training显示文摘 | Banz R Bolliger M Colombo G | 2008 | Phys Ther2008，88，10： | 1 |
| 19 | A diffusion tensor magnetic resonance imaging study of brain tissue from patients with migraine 显示文摘 | Rocca MA Colombo B Inglese M | 2003 | J Nerol Neurosurg Psychiatry2003，74，4： | 1 |
| 20 | Functional conservation of MADS- box factors controlling floral organ identity in rice and Arabidopsis 显示文摘 | Kater M M Dreni L Colombo L | 2006 | Journal of Experimental Botany2006，57，： | 1 |
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