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| 1 | Paternal physical exercise modulates global DNA methylation status in the hippocampus of male rat offspring显示文摘It is widely known that maternal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of paternal exercise have not been explored in detail. The present study was designed to evaluate the impact of paternal physical exercise on memory and learning, neuroplasticity and DNA methylation levels in the hippocampus of male offspring. Adult male Wistar rats were divided into two groups: sedentary or exercised fathers. The paternal preconception exercise protocol consisted of treadmill running, 20 minutes daily, 5 consecutive days per week for 22 days, while the mothers were not trained. After mating, paternal sperm was collected for global DNA methylation analysis. At postnatal day 53, the offspring were euthanized, and the hippocampus was dissected to measure cell survival by 5-bromo-2′-deoxiuridine and to determine the expression of synaptophysin, reelin, brain-derived neurotrophic factor and global DNA methylation levels. To measure spatial memory and learning changes in offspring, the Morris water maze paradigm was used. There was an improvement in spatial learning, as well as a significant decrease in hippocampal global DNA methylation levels in the offspring from exercised fathers compared with those from sedentary ones; however, no changes were observed in neuroplasticity biomarkers brain-derived neurotrophic factor, reelin and 5-bromo-2′-deoxiuridine. Finally, the global DNA methylation of paternal sperm was not significantly changed by physical exercise. These results suggest a link between paternal preconception physical activity and cognitive benefit, which may be associated with hippocampal epigenetic programming in male offspring. However, the biological mechanisms of this modulation remain unclear. | Christiano Spindler Ethiane Segabinazi Andre Luis Ferreira de Meireles Francele Valente Piazza Filipe Mega Gabriela dos Santos Salvalaggio Matilde Achaval Viviane Rostirola Elsner Simone Marcuzzo | 2019 | Neural Regeneration Research2019，14，3： | 3 |
| 2 | Optimizing accuracy in magnetic resonance imaging-guided stereotaxis:A technique with validation based on the anterior commissure-posterior commissure line 显示文摘 | diPierro CG Francel PC Jackson TR | 1999 | Neurosurgery1999，90，1： | 1 |
| 3 | Acrylic cranioplasty using miniplate struts 显示文摘 | Replogle R E Lanzino G Francel P | 1996 | Neurosurgrey1996，39，4： | 1 |
| 4 | Quadrilateral space syndrome:diagnosis and operative decompression显示文摘 | Francel TS Dellon AL Campbell JN | 1991 | Technigue PRS1991，8，： | 1 |
| 5 | The Fate of Plates and Screws after Facial Fracture Reconstruction显示文摘 | Thomas J. Francel Brent C. Birely Paul R. Ringelman Paul N. Manson | 1992 | Plastic and Reconstructive Surgery1992，，4： | 1 |
| 6 | Metabolic Engineering of Terpenoid Biosynthesis in Plants显示文摘 | Asaph Aharoni Maarten A. Jongsma Tok-Yong Kim Man-Bok Ri Ashok P. Giri Francel W. A. Verstappen Wilfried Schwab Harro J. Bouwmeester | 2006 | Phytochemistry Reviews2006，，1： | 1 |
| 7 | Pharmacological study of levocetirizine in IgE-dependent hypersensitivity cutaneous reaction in grass pollen allergic volunteers:demonstreation of mediator release and eosinophil recruitment modulation by levocetirizine显示文摘 | Laurence M Francelle J Veronigue L | 2001 | J Invest Dermatol2001，117，3： | 1 |
| 8 | A rational approach to wound difficulties after sternotomy:reconstruction and long-term results显示文摘 | Francel TJ Kouchoukos NT | 2001 | Ann Thorac Surg2001，72，： | 1 |
| 9 | A rational approach to wound difficulties after stemotomy: reconstruction and long-term results显示文摘 | Francel TJ Kouchoukos NT | 2001 | Ann Thorac Surg2001，72，4： | 1 |
| 10 | Geochemical and isotopic variations in the cal-alkaline rocks of Aeolian arc,southern Tyrrhenian Sea,Italy:Constraints on magma genesis显示文摘 | Francelanci L Taylor S R Mcculloch M T | 1993 | Contrib Mineral Petrol1993，113，： | 1 |
| 11 | Acrylic cranioplasty using miniplate struts显示文摘 | Replogle R E Lanzino G Francel P | 1995 | Neurosurgrey1995，39，4： | 1 |
| 12 | 上海天文馆显示文摘上海天文馆坐落于滴水湖畔,总面积约3.8万m^(2)作为上海科技馆分馆,是全球规模最大的天文学主题博物馆。其致力于营造沉浸式体验,让游客可以与各种天文现象直接互动,并通过对比例、形态以及光线的细致处理,提升人们对于太阳和地球轨道运动之间的基本关系的认知。 | 无 V.Guy Maxwell Grace Chen Wei Wei Kuang Charles Wolf Anthony Guaraldo Jorge Arias Margarita Calero Michael Caton Christina Ciardullo Eugene Colberg Regina Jiang Jörg Kiesow Aidan Kim Stefan Knust Xinya Li Francelle Lim Xiaoyun Mao David Monnar Nikita Payusov James Rhee Yong Kyun Roh Miya Ruan Na Sun Eric Tsui Stephanie Tung Charles Wong David Yu Fred Zhang | 2022 | 建筑实践2022，，5： | 1 |
| 13 | 浩瀚宇宙的秘密 上海天文馆显示文摘上海天文馆由Ennead建筑设计事务所设计合伙人Thomas J.Wong设计。其方案致力于营造沉浸式体验,让游客可以与各种天文现象直接互动,并通过对比例、形态以及光线的细致处理,提升人们对于太阳和地球轨道运动这一基本关系的认知。作为上海科技馆分馆,全新的上海天文馆占地38000 m^(2),为全球规模最大的天文学主题博物馆。 | 无 V.Guy Maxwell(设计) 陈昕昉(设计) 邝薇薇(设计) Charles Wolf(设计) Anthony Guaraldo(设计) Jorge Arias(设计) Margarita Calero(设计) Michael Caton(设计) Christina Ciardullo(设计) Eugene Colberg(设计) Regina Jiang(设计) Jörg Kiesow(设计) Aidan Kim(设计) Stefan Knust(设计) 李欣亚(设计) Francelle Lim(设计) Xiaoyun Mao(设计) David Monnar(设计) Nikita Payusov(设计) James Rhee(设计) Yong Kyun Roh(设计) 阮玲丽(设计) Na Sun(设计) 徐震(设计) Stephanie Tung(设计) 黄泽修(设计) 于乐川(设计) Fred Zhang(设计) | 2021 | 室内设计与装修2021，，9： | 1 |
| 14 | Metabolic Engineering of Terpenoid Biosynthesis in Plants显示文摘 | Asaph Aharoni Maarten A. Jongsma Tok-Yong Kim Man-Bok Ri Ashok P. Giri Francel W. A. Verstappen Wilfried Schwab Harro J. Bouwmeester | 2006 | Phytochemistry Reviews2006，，1： | 1 |
| 15 | The metabolite chemotype of N icotiana benthamiana transiently expressing artemisinin biosynthetic pathway genes is a function of CYP 71 AV 1 type and relative gene dosage显示文摘 | Hieng‐Ming Ting Bo Wang Anna‐Margareta Rydén Lotte Woittiez Teun Herpen Francel W. A. Verstappen Carolien Ruyter‐Spira Jules Beekwilder Harro J. Bouwmeester Alexander Krol | 2013 | New Phytol2013，，2： | 1 |
| 16 | Families' Perceptions of Burden of Care for Chronic Mentally Ⅲ Relatives显示文摘 | Francell C.G Conn V.S Gray D.P | | 0，，12： | 1 |
| 17 | Anatomic and clinical consi derations of an internal mammary artery harvest 显示文摘 | Dufresne CR Baumgartner WA | 1992 | Arch Surg1992，127，9： | 1 |
| 18 | A rational approach to wound difficulties after sternotomy:reconstruction and long-term results显示文摘 | FRANCEL J KOUCHOUKOS N T | 2001 | Ann Thorac Surg2001，72，4： | 1 |
| 19 | Anatomic and clinical considerations of an internal mammary artery harvest显示文摘 | Francel TJ Dufresne CR Baumgartner WA | 1992 | Arch Surg1992，127，： | 1 |
| 20 | Micrevascular soft tissue transplantation for reconstruction of acute open tibial fractures : timing of coverage and long term functional results 显示文摘 | Francel T Vander Kolk C Hoopes J | 1992 | Plast Reconstr Surg1992，89，3： | 1 |
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