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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 3 | Long-term prognostic value of analysis of sympathetic drive by myocardial 123I-metaiodobenzylganidine scintigraphy in chronic heart failure显示文摘背景过去在长期的心失败( CHF )的同情的开车的增加与为 scintigraphy 是的 disease.Myocardial 123I-metaiodobenzylganidine ( MIBG )的恶化和死亡的主要责任与学习的 CHF.The 目的在病人估计同情的机能障碍的一个非侵略的方便方法是检测同情的 antidrive 是否分析了通过心肌的 MIBG scintigraphy 在 CHF.Methods 在长期的预后起一个关键作用 64 注册病人 underwe 但是它的休息 LVEF 和 NYHA 功能班不是显著地, different.H/M ,宏和 BNP 与死亡密切相关( P=0.000 , 0.000 和 0.001 ,分别地) .Among H/M 的死亡风险比率( RR )是的三指示物 4.66 ,多于宏和 BNP ( 1.88 和 2.56 ,分别地) .However ,休息 LVEF 和 NYHA 函数班没与死亡相关( P=0.652 并且 0.384 ,分别地)有更低的 H/M 和宏的 .The 组,更高的 BNP 比与更高的 H/M 和宏,降低 BNP 的有更多死亡, RR | CAO Ya-min Jourdain Patrick Funck Fran(c)ois | 2010 | Chinese Medical Journal2010，，15： | 2 |
| 4 | Characterization of Hepatitis C Virus Particle Subpopulations Reveals Multiple Usage of the Scavenger Receptor BI for Entry Steps显示文摘 | Viet Loan Dao Thi Christelle Granier Mirjam B. Zeisel Maryse Guérin Jimmy Mancip Ophélia Granio Fran?ois Penin Dimitri Lavillette Ralf Bartenschlager Thomas F. Baumert Fran?ois-Lo?c Cosset Marlène Dreux | 2012 | Journal of Biological Chemistry2012，，37： | 2 |
| 5 | Biocontrol of sheath blight by Trichoderma asperellum in tropical lowland rice 显示文摘 | de Fran~a S K S Cardoso A F Lustosa D C | 2015 | Agronomy for Sustainable Development2015，35，1： | 1 |
| 6 | Hepatosplenic gamma/delta T-cell lymphoma:a report of two cases in immunocompromised patients,associated with isochromosome 7q显示文摘 | Fran(c)ois A Lesesve JF Stamatoullas A | 1997 | Am J Surg Pathol1997，21，7： | 1 |
| 7 | High-Dose Split-Course Radiation Therapy for Anal Cancer: Outcome Analysis Regarding the Boost Strategy (CORS-03 Study)显示文摘 | Jean-Michel Hannoun-Levi Cécile Ortholan Michel Resbeut Eric Teissier Philippe Ronchin Didier Cowen Audrey Zaccariotto Karen Bénézery Eric Fran?ois Naji Salem Steve Ellis David Azria Jean-Pierre Gerard | 2011 | International Journal of Radiation Oncology Biology Physics2011，，3： | 1 |
| 8 | A model to predict short-term death or readmission after intensive care unit discharge显示文摘 | Ouanes I Schwebel C Fran(c)ais A | | 0，，： | 1 |
| 9 | Erosion of Deccan Traps determined by river geochemistry: impact on the global climate and the 87Sr/86Sr ratio of seawater显示文摘 | Dessert C Dupré B Fran?ois L M | 2001 | Earth and Planetary Science Letters2001，188，34： | 1 |
| 10 | Quality of life of adults with spinal cord injury:a study using the WHOQOL-bref显示文摘 | De Fran(C)a IS Coura AS de Fran(C)a EG | 2011 | Rev Esc Enferm USP2011，45，6： | 1 |
| 11 | Influence of Irradiation on the Oxide Film Formed on 316 L Stainless Steel in PWR Primary Water显示文摘 | Stéphane Perrin Loic Marchetti Cécilie Duhamel Mohamed Sennour Fran?ois Jomard | 2013 | Oxidation of Metals (-)2013，，5： | 1 |
| 12 | Stochastic security for operations planning with significant wind power generation显示文摘 | Fran(c)ois Bouffard Galiana F D | 2008 | IEEE Trans on Power Systems2008，23，2： | 1 |
| 13 | Calibration and validation of hyperspectral indices for the estimation of broadleaved forest leaf chlorophyll content, leaf mass per area,leaf area index,and leaf canopy biomass显示文摘 | Maire G L Franois C Soudani K | 2008 | Remote Sensing of Environment2008，112，10： | 1 |
| 14 | Usefulness of 2‐[<sup>18</sup>F]‐fluoro‐2‐deoxy‐ d ‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study显示文摘 | Mikael Ebbo Aurélie Grados Eric Guedj Delphine Gobert Cécile Colavolpe Mohamad Zaidan Agathe Masseau Fanny Bernard Jean‐Marie Berthelot Nathalie Morel Fran?ois Lifermann Sylvain Palat Julien Haroche Xavier Mariette Bertrand Godeau Emmanuelle Bernit Nathal | 2014 | Arthritis Care & Research2014，，1： | 1 |
| 15 | NMR relaxometry and differential scanning calorimetry during meat cooking 显示文摘 | Hanne C B Zhiyun W Frans B | 2006 | Meat Science2006，74，： | 1 |
| 16 | Energy analysis of advanced collective farms in North China显示文摘 | HAN C R FRAN G ZHENG G M | 1985 | Agrculture Ecosystems and Environment1985，13，： | 1 |
| 17 | Two different Em-like genes are expressed in Arabidopsis thaliana seeds during maturation显示文摘 | Pascale Gaubier Monique Raynal Gillian Hull Gordon M. Huestis Fran?oise Grellet César Arenas Montserrat Pagès Michel Delseny | 1993 | MGG Molecular & General Genetics1993，，3： | 1 |
| 18 | Ni-exchanged AlMCM-41:An efficient bifunctional catalyst for ethylene oligomerization显示文摘 | Fran(c)ois F | 2004 | Journal of Catalysis2004，225，： | 1 |
| 19 | Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers:a double-blind,randomised,placebo-controlled,cross-over trial显示文摘 | FRAN(C)OIS I E LESCROAT O VERAVERBEKE W S | 2012 | British Joumal of Nutrition2012，108，12： | 1 |
| 20 | MFIX simulation of NETL/PSRI challenge problem of circulatinguidized bed显示文摘 | LI T W FRAN J DIETIKER C | 2012 | Chemical Engineering Science2012，84，： | 1 |
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