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| 1 | 熔融沉积法制备纤维素纳米纤维增强聚乳酸基复合材料的拉伸性能显示文摘生物可降解聚合物可以在保持结构力学性能的同时可以实现碳中性,是石油基聚合物的潜在替代品。在这些聚合物中,聚乳酸(Polylactic acid,PLA)因其良好的力学性能、生物相容性和热塑性而特别有发展前景。本文利用机械脱脂纤维素纳米纤维(Cellulose nanofiber,CNF)来提高聚乳酸的力学性能,该纤维具有显著的力学性能和生物降解性。熔融沉积建模(Fused deposition modeling,FDM)是热塑性聚合物的三维打印方法之一,可以降低制造成本。本研究采用FDM法制备了机械脱脂CNF增强PLA基复合材料,并在两个打印方向(0°/90°和+45°/-45°)上研究了它们的拉伸性能,梳理了机械制备CNF增强PLA基复合材料的印刷方向与拉伸行为之间的关系。此外,利用扫描电镜研究了机械脱脂CNF增强PLA基复合材料的显微组织和断口。 | KURITA Hiroki BERNARD Chrystelle LAVROVSKY Agathe NARITA Fumio | 2021 | Transactions of Nanjing University of Aeronautics and Astronautics2021，38，1： | 5 |
| 2 | Bilateral versus unilateral cryptorchidism in nonobstructive azoospermia:testicular sperm extraction outcomes显示文摘Cryptorchidism is one of the most frequent causes of nonobstructive azoospermia(NOA)in adulthood.Although it is well known that spermatogenesis is more impaired in bilateral than in unilateral cryptorchidism,previous studies have only described small cohorts or inhomogeneous population.Consequently,we analyzed a cohort of 225 men with only a history of cryptorchidism as sole etiopathogenetic factor for NOA,and compared testicular sperm extraction(TESE)outcomes between men with bilateral versus unilateral cryptorchidism.Our results show no difference in follicle-stimulating hormone(FSH)levels and testicular volumes between men with a history of bilateral cryptorchidism compared to unilateral cryptorchidism(median:21.3 IU I^-1 vs 19.3 IU I^-1,P=0.306;and 7.2 ml vs 7.9 ml,P=0.543,respectively).In addition,sperm retrieval rates were similar(66.2%vs 60.0%,P=0.353).Using multivariate analysis,we have found that only a low inhibin B level(above the assay's detection limit)was positively associated with successful sperm retrieval(P<0.05).Regarding intracytoplasmic sperm injection outcomes,we found that cumulative pregnancy rate and live birth rate per cycle were not statistically different between the two groups(17.4%vs 27.8%,P=0.070;and 16.1%vs 26.4%,P=0.067,respectively).Unexpectedly,there was no significant difference in hormonal profiles(FSH,luteinizing hormone[LH],testosterone,and inhibin B levels)and TESE outcomes between unilateral versus bilateral cryptorchidism.This suggests that a history of unilateral cryptorchidism could reflect a bilateral testicular impairment.Interestingly,inhibin B level might be a predictor of successful TESE. | Anne-Laure Barbotin Anais Dauvergne Agathe Dumont Nassima Ramdane Valerie Mitchell Jean-Marc Rigot Florence Boitrelle Geoffroy Robin | 2019 | Asian Journal of Andrology2019，21，5： | 4 |
| 3 | Quality of life, physical performance and nutritional status in older patients hospitalized in a cardiology department显示文摘Objectives Quality of life(QoL) is a priority outcome in older adults suffering from cardiovascular diseases. Frailty and poor nutritional status may affect the QoL through mobility disorders and exhaustion. The objective of this study was to determine if physical frailty and nutritional status were associated with QoL, in older cardiology patients. Methods Cross sectional, observational study conducted in a cardiology department from a university hospital. Participants(n = 100) were aged 70 and older. Collected data included age, sex, cardiac diseases, New York Heart Association(NYHA) classification, comorbidities(Charlson Index) and disability. A Short Physical Performance Battery(SPPB), including walking speed assessment was performed;handgrip strength were measured as well as Fried’s frailty phenotype. Nutritional status was assessed using the Mini Nutritional Assessment(MNA) and Body Mass Index(BMI), inflammation by C-reactive protein(CRP). QoL was assessed using the EORTC–QLQ questionnaire. Univariate and multivariate analyses were performed to study the associations between all recorded parameters and QoL. Results In participants(mean age: 79.3 ± 6.7 years;male: 59%), Charlson index, arrhythmia, heart failure, NYHA class III-IV, MNA, disability, walking speed, SPPB score, frailty and CRP were significantly associated with QoL in univariate analysis. Multivariate analysis showed that NYHA class III-IV(P < 0.001), lower MNA score(P = 0.03), frailty(P < 0.0001), and higher CRP(P < 0.001) were independently associated with decreased QoL. Conclusions Frailty, nutritional status and inflammation were independently associated with poor QoL. Further studies are needed to assess the efficacy of nutritional and physical interventions on QoL in this population. | Matthieu Lilamand Mariannick Saintout Marie Vigan Astrid Bichon Laure Tourame Aurélie Brembilla Diet Bernard Iung Dominique Himbert Cédric Laouenan Agathe Raynaud-Simon | 2020 | Journal of Geriatric Cardiology2020，17，7： | 3 |
| 4 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 5 | IL-18 Enhances IL-4 production by ligand-activated NKT lymphocytes:a Pro-Th2 effect of IL-18 exerted through NKT cells显示文摘 | AGATHE H MARIA P | 2001 | J Immunol2001，166，： | 1 |
| 6 | Expression of laccase IIIb from the white-rot fungus Trametes versicolor in the yeast Yarrowia lipolytica for environmental applications显示文摘 | Claude J Catherine M Agathe B | 2005 | Applied Microbiology and Bioteehnology2005，66，： | 1 |
| 7 | Does recombinant hu- man thyrotropin-stimulated positron emission tomography with fluoro-2-deoxy-D-glucose improve detection of recurrence of well-differentiated thyroid carcinoma in patients with low serum thyroglobulin?显示文摘 | Vera P Caroline KL Agathe ES | 2010 | Thyroid2010，20，1： | 1 |
| 8 | Usefulness of 2‐[<sup>18</sup>F]‐fluoro‐2‐deoxy‐ d ‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study显示文摘 | Mikael Ebbo Aurélie Grados Eric Guedj Delphine Gobert Cécile Colavolpe Mohamad Zaidan Agathe Masseau Fanny Bernard Jean‐Marie Berthelot Nathalie Morel Fran?ois Lifermann Sylvain Palat Julien Haroche Xavier Mariette Bertrand Godeau Emmanuelle Bernit Nathal | 2014 | Arthritis Care & Research2014，，1： | 1 |
| 9 | 新型多孔增效氧化锌在断奶仔猪消化道内的抗菌作用显示文摘众所周知,断奶仔猪日粮中添加氧化锌可以提高生长性能并能有效地降低仔猪断奶后的腹泻,但是为什么其他形态的锌源在控制断奶仔猪腹泻上没有氧化锌效果显著呢?下面让我们看一下氧化锌的抗菌作用。 | Valerie Kromm Agathe Romeo 张永刚(译) 张津校(校) 李升生(校) | 2020 | 广东饲料2020，，7： | 1 |
| 10 | Electrostatic atomization of hydrocarbon fuels and bio-alcohols for engine applications显示文摘 | Agathou M S Kyritsis D C | 2012 | Energy Conversion and Management2012，，60： | 1 |
| 11 | Lack of progressive arteriopathy and stroke recurrence among children with cryptogenic stroke显示文摘 | Stephane Darteyre Stephane Chabrier Emilie Presles Alain Bonafé Agathe Roubertie Bernard Echenne Nicolas Leboucq Francois Rivier | 2012 | Neurology2012，，24： | 1 |
| 12 | Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation显示文摘BACKGROUND Chronic abdominal pain is the most common cause for gastroenterology consultation and is frequently associated with functional gastrointestinal disorders including irritable bowel syndrome and inflammatory bowel disease. These disorders present similar brain/gut/microbiota trialogue alterations, associated with abnormal intestinal permeability, intestinal dysbiosis and colonic hypersensitivity(CHS). Intestinal dysbiosis can alter colon homeostasis leading to abnormal activation of the innate immunity that promotes CHS, perhaps involving the toll-like receptors(TLRs), which play a central role in innate immunity.AIM To understand the mechanisms between early life event paradigm on intestinal permeability, fecal microbiota composition and CHS development in mice with TLRs expression in colonocytes.METHODS Maternal separation model(NMS) CHS model, which mimics deleterious events in childhood that can induce a wide range of chronic disorders during adulthood were used. Colonic sensitivity of NMS mice was evaluated by colorectal distension(CRD) coupled with intracolonic pressure variation(IPV) measurement. Fecal microbiota composition was analyzed by 16S rRNA sequencing from weaning to CRD periods. TLR mRNA expression was evaluated in colonocytes.Additionally, the effect of acute intrarectal instillation of the TLR5 agonist flagellin(FliC) on CHS in adult naive wildtype mice was analyzed.RESULTS Around 50% of NMS mice exhibited increased intestinal permeability and CHS associated with intestinal dysbiosis, characterized by a significant decrease of species richness, an alteration of the core fecal microbiota and a specific increased relative abundance of flagellated bacteria. Only TLR5mRNA expression was increased in colonocytes of NMS mice with CHS. Acute intrarectal instillation of FliC induced transient increase of IPV, reflecting transient CHS appearance.CONCLUSION Altogether, these data suggest a pathophysiological continuum between intestinal dysbiosis and CHS, with a role for TLR5. | Geoffroy Mallaret Amandine Lashermes Mathieu Meleine Ludivine Boudieu Julie Barbier Youssef Aissouni Agathe Gelot Benoit Chassaing Andrew T Gewirtz Denis Ardid Frederic Antonio Carvalho | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 13 | Electrostatic atomization of hydrocarbon fuels and bio-alcohols for engine applications 显示文摘 | AGATHOU M KYRITSIS D | 2012 | EnergyConversion and Management2012，60，： | 1 |
| 14 | Expression of laccase IIIb from the white - rot fungus Trametes versicolor in the yeast Yarrowia lipolytica for environmental applications 显示文摘 | Claude Jolivalt Catherine Madzak Agathe Brauh | 2005 | Appl Microbiol Biotechnol2005，66，： | 1 |
| 15 | The gene family encoding the Arabidopsis thaliana translation elongation factor EF-1α: Molecular cloning, characterization and expression显示文摘 | Michèle Axelos Claude Bardet Thierry Liboz Agathe Thai Catherine Curie Bernard Lescure | 1989 | MGG Molecular & General Genetics (-)1989，，1： | 1 |
| 16 | 断奶仔猪日粮中氧化锌的抗菌作用显示文摘众所周知,日粮中的氧化锌可加快仔猪的生长,减少仔猪断奶后的腹泻。但其他形式的锌为什么不能产生像氧化锌那样的作用呢?让我们来了解氧化锌的抗菌活性。 | 唐彩琰(译) 陈建康(校) valérie kromm agathe roméo | 2017 | 国外畜牧学(猪与禽)2017，0，7： | 1 |
| 17 | IL-18 Enhances IL-4 production by ligand-activated NKT lymphocytes:a Pro-Th2 effect of IL-18 exerted through NKT cells显示文摘 | Maria CL Agathe H Maria P | 2001 | J Immunol2001，166，2： | 1 |
| 18 | Charae- terisation of mechanical non-linearities in a proton exchange membrane fuel cell using raw data显示文摘 | Vieky Rouss Willy Charon Agathe Desflots | 2009 | In- ternational Journal of Hydrogen Energy2009，34，： | 1 |
| 19 | Involvement of the Ubiquitin/Proteasome System in Sorting of the Interleukin 2 Receptor β Chain to Late Endocytie Compartments 显示文摘 | Anna R Christophe L Agathe S | 2001 | Mol Biol Cell2001，12，： | 1 |
| 20 | 铜、锌有助于微生物产生耐药性显示文摘在养猪生产中,为了解决抗生素耐药性问题,不仅需要减少抗生素的使用,还要了解日粮中添加铜和锌对微生物产生耐药性所起的作用。 | 张永刚 Agathe Romeo | 2015 | 中国畜牧杂志2015，51，16： | 1 |
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