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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 4 | Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing 显示文摘 | Chamberlain G Fox J Ashton B | 2007 | Stem Cdls2007，25，11： | 1 |
| 5 | Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stettroyl-CoA desaturase, and are cmmerved in alkane hydroxylase and xylene monooxygenase显示文摘 | Shankin J Whittle E Fox B G | 1994 | Bichemistry1994，33，12： | 1 |
| 6 | The chemistry of meat pigments显示文摘 | Jay B Fox | 1966 | Food Processing1966，14，： | 1 |
| 7 | Monoclonal autibody to the glycoprotein of VSV显示文摘 | Bricker B J Snyder R W Fox J W | 1997 | Virology1997，161，2： | 1 |
| 8 | Social support in later life : examining the roles of childhood and adulthood cognition 显示文摘 | Bourne V J Helen C Fox B | 2007 | Personal Individ Dif- fer2007，43，： | 1 |
| 9 | Proton exchange membrane(PEM)electrolyzer operation under anode liquid and cathode vapor feed configurations显示文摘 | GREENWAY S D FOX E B EKECHUKWU A A | 2009 | International Journal of Hydrogen Energy2009，34，16： | 1 |
| 10 | Nuclear locali- zation of Myomesin-l: Possible functions显示文摘 | Reddy K B Fox J E Priee M G | 2008 | Muscle Res Cell Motil2008，29，1： | 1 |
| 11 | Introduction to a system for distributed databases (SDD-1)显示文摘 | Rothnie Jr J B Bernstein P A Fox S | 1980 | ACM Transactions on Database Systems (TODS)1980，5，1： | 1 |
| 12 | Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events(TRA 2°P)-TIMI 50 trial 显示文摘 | MORROW D A SCIRICA B M FOX K A | 2009 | Am Heart J2009，158，3： | 1 |
| 13 | Radiation dose reduction for CT lung cancer screening using ASIR and MBIR: a phantom study显示文摘 | Mathieu K B Ai H Fox P S | 2014 | J Appl Clin Med Phys2014，15，2： | 1 |
| 14 | Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus 显示文摘 | Fox J G Yan L Shames B | 1996 | Infect Immun1996，64，9： | 1 |
| 15 | TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts显示文摘 | Wong B Fox S | 1998 | J Exp Med1998，188，5： | 1 |
| 16 | The Psychology self-perception profile:Development and preliminary validation显示文摘 | Fox K R Corbin C B | 1989 | Journal of Sport and Exercise Psychology1989，11，： | 1 |
| 17 | Performance and Properties of Mould Fluxes显示文摘 | Mills K C Fox A B Li Z | 2005 | Ironmaking Steelmaking2005，32，1： | 1 |
| 18 | Synthesis of New Indeno iso- quinolines: Cytotoxic Non-Camptothecin Topoi- somerase I Inhibitors 显示文摘 | JAYARAMAN M FOX B M HOLLINGSHEAD M etal | 2010 | J Med Chem2010，43，4： | 1 |
| 19 | Developments in clinical cell therapy显示文摘 | Stroncek D Berlyne D Fox B | 2010 | Cytotherapy2010，12，3： | 1 |
| 20 | GRACE Investigators Relationship of treatment delays and mortality in patients undergoing fibrinolysis and primary percutaneous coronary intervention:the Global Registry of Acute Coronary Events显示文摘 | Nallamothu B Fox KA Kennelly BM | 2007 | Heart2007，93，12： | 1 |
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