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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | Levobupivacaine A Review of its pharmacology and use as a local Anaesthetic 显示文摘 | Rachel H Foster Anthony Markham | 2000 | Drugs2000，59，3： | 2 |
| 3 | The 2-pebbling property and a conjecture of Graham's显示文摘 | Foster J A | 2000 | Graphs Combin2000，16，2： | 1 |
| 4 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 5 | Autonomic imbalance hypothesis and overtraining syndrome 显示文摘 | Lehmann M Foster C Dickhuth H H | 1998 | Med Sci Sports Exercise1998，30，7： | 1 |
| 6 | Chitosan-van- comysin composite biomaterial as a laser activated surgical adhesive with regional antimicrobial activity显示文摘 | Foster LJ Thomson K Marcal H | 2010 | Biomacro- molecules2010，11，12： | 1 |
| 7 | The definition and classification of glaucoma in prevalence surveys 显示文摘 | FOSTER P J BUHRMANN R QUIGLEY H A | 2002 | Br J Ophthalmol2002，86，2： | 1 |
| 8 | Levobupivacaine:a review of its pharmacology and use as a local anaesthetic显示文摘 | FOSTER R H MARKHAM A | 2000 | Drugs2000，59，： | 1 |
| 9 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 10 | Intravenous lidocaine and oral mexileline block reflex bronchoconstrtion in asthmatic subj- ects显示文摘 | Groeben H Foster WM Brown RH | 1996 | Am J Respir Crit care Med1996，，4： | 1 |
| 11 | Unsuspected gallbladder cancer diagnosed during or after laparoscopic cholecysteetomy显示文摘 | Foster JM Hoshi H Gibbs JF | | 0，，： | 1 |
| 12 | Beam steering with pulsed two dimensional transducer arrays显示文摘 | TURNBULL D H FOSTER F S | 1991 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control1991，38，4： | 1 |
| 13 | T cells and B cells in Lupus nephritis显示文摘 | Foster M H | 2007 | Semin Nephrol2007，27，1： | 1 |
| 14 | Levobupivacaine a review of its pharmacology and use as a local anaesthetic显示文摘 | Foster R H Markham A | 2000 | Drugs2000，59，： | 1 |
| 15 | Longevity and Selenium deficiency:evidence from the People's Republic of China显示文摘 | Foster H D Zhang L | 1995 | The Science of the Total Environment1995，170，： | 1 |
| 16 | Association of chronic kidney disease with muscle deficits in children 显示文摘 | Foster B J Kalkwarf H J Shults J | 2011 | J Am Soc Nephrol2011，22，2： | 1 |
| 17 | Highly bioactive silver and silver/titania composite films grown by chemical vapour deposition显示文摘 | Brook L A Evans P Foster H A Pemble M E | 2007 | Journal of Photochemistry and Photobiology A:Chemistry2007，187，1： | 1 |
| 18 | Development of a multiple-drug delivery implant for intraocular management of显示文摘 | Zhou T Lewis H Foster RE Schwendeman SP | 1998 | J Control Release1998，55，： | 1 |
| 19 | Field survey andliterature review on traditional fermented milk products of Ethiopia显示文摘 | GONFA A FOSTER H A HOLZAPFEL W H | 2001 | International Journal of Food Microbiology2001，68，： | 1 |
| 20 | Integrins:novel therapeutic targets for cardiovascular diseases显示文摘 | Lal H Guleria RS Foster DM | 2007 | Cardiovasc Hematol Agents Med Chem2007，5，2： | 1 |
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