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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | The specific adsorption of divalent Cd, Co, Cu, Pb and Zn on goethite 显示文摘 | FORBES E A POSNER A M QUIRK J P | 1976 | J Soil Sci1976，27，： | 1 |
| 3 | Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease显示文摘 | Burn W C Twigg S M Forbes J M | 2006 | J Am Soc Nephrol2006，17，9： | 1 |
| 4 | Synthesis显示文摘 | Forbes D C Ene D G Doyle M P | 1998 | 6:8791998，6，： | 1 |
| 5 | Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects 显示文摘 | CALKIN A C FORBES J M SMITH C M | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 6 | Photovoltaie solar cells : an overview of state-of-the-art cell development and environmental issues 显示文摘 | MILES R W HYNES K M FORBES I | 2005 | Progress in Crystal Growth and Characterization of Materials2005，51，13： | 1 |
| 7 | Supercritical fluid processing of proteins I:lysozyme precipitation from organic solution显示文摘 | Moshashaee S Bisrat M Forbes RT | 2000 | Eur J Pharm Sci2000，11，3： | 1 |
| 8 | Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase显示文摘 | Aino Soro-Paavonen Wei-Zeng Zhang Kylie Venardos Melinda T Coughlan Emma Harris David CK Tong Daniella Brasacchio Karri Paavonen Jaye Chin-Dusting Mark E Cooper David Kaye Merlin C Thomas Josephine M Forbes | 2010 | Journal of Hypertension2010，，4： | 1 |
| 9 | K-252a promotes survival and choline acetyltransferase activity in striatal and basal forebrain neuronal cultures 显示文摘 | Glicksman M A Forbes M E Pranmer J E | 1995 | J Neurochem1995，64，： | 1 |
| 10 | Psychiatric disorder and separation from military service:a 10-year retrospective study显示文摘 | Creamer M Carboon I Forbes AB | 2006 | Am J Psychiatry2006，163，4： | 1 |
| 11 | Biomaterials for Blood-Contacting Applications显示文摘 | J M Courtney N M K Lamba M Sundaram C D Forbes | 1994 | Biomaterials1994，10，： | 1 |
| 12 | Successful treatment of post-transplant lymphoproliferative disorder with interferon-alpha and intravenous immunoglobulin显示文摘 | Cantarovich M Barkun JS Forbes RD | 1998 | Clin Transplant1998，12，2： | 1 |
| 13 | Modulation of nephrin in the diabetic kidney:association with systemic hypertension and increasing albuminuria 显示文摘 | Forbes J M Bonnet F Russo L M | 2002 | J Hypertens2002，20，5： | 1 |
| 14 | Refining the In-Parameter- Order Strategy for Constructing Covering Arrays 显示文摘 | Forbes M Lawrence J Lei Y | 2008 | Journal of Research of the National Institute of Standards and Technology2008，113，5： | 1 |
| 15 | Modulation of soluble receptor for advanced glycation end products by angiotensin - converting enzyme - 1 inhibition in diabetic nephropathy 显示文摘 | FORBES J M THORPE S R THALLAS - BONKE V | 2005 | J Am Soc Nephro12005，16，8： | 1 |
| 16 | Exploiting tumor epigeneties to improve oncolytie virotherapy 显示文摘 | Forbes NE Abdelbary H Lupien M | 2013 | Front Genet2013，4，： | 1 |
| 17 | Formation,transformation and transport of black carmn (charcoal) in terrestrial and aquatic ecosystems显示文摘 | FORBES M S RAISON R J SKJEMSTAD J O | | 0，，01： | 1 |
| 18 | Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy 显示文摘 | Forbes M Cooper ME Thallas V etal | 2002 | Diabetes2002，，： | 1 |
| 19 | The Overrepresentation of a White Minority:Detroit's At-Large City Council, 1961-1989显示文摘 | Herring M Forbes J | 1994 | Social Science Quarterly1994，75，： | 1 |
| 20 | Photovoltaic solar cells: an overview of state-of-the-art cell development and environmental issues显示文摘 | MILES R W HYNES K M FORBES I | 2005 | Progress in Crystal Growth and Characterization of Materials2005，51，13： | 1 |
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