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| 1 | Novel genetic markers in inflammatory bowel disease显示文摘Genetic factors play a significant role in determining inflammatory bowel disease(IBD)susceptibility.Epidemiologic data support genetic contribution to the pathogenesis of IBD,which include familial aggregation,twin studies,racial and ethnic differences in disease prevalence.Linkage studies have identified several susceptibility genes contained in different genomic regions named IBD1 to IBD9.Nucleotide oligomerization domain(NOD2)and human leukocyte antigen(HLA)genes are the most extensively studied genetic regions(IBD1 and IBD3 respectively)in IBD.Mutations of the NOD2 gene are associated with Crohn's disease(CD)and several HLA genes are associated with ulcerative colitis(UC)and CD.Toll like receptors(TLRs)have an important role in the innate immune response against infections by mediating recognition of pathogen-associated microbial patterns.Studying single-nucleotide polymorphisms(SNPs)in molecules involved in bacterial recognition seems to be essential to define genetic backgrounds at risk of IBD.Recently,numerous new genes have been identified to be involved in the genetic susceptibility to IBD:NOD1/Caspase-activation recruitment domains 4(CARD4),Chemokine ligand 20(CCL20),IL-11,and IL-18 among others.The characterization of these novel genes potentially will lead to the identification of therapeutic agents and clinical assessment of phenotype and prognosis in patients with IBD. | Lorena Rodríguez-Bores Gabriela C Fonseca Marco A Villeda Jesús K Yamamoto-Furusho | 2007 | World Journal of Gastroenterology2007，13，42： | 8 |
| 2 | Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial显示文摘 | S Vincent Rajkumar Susanna Jacobus Natalie S Callander Rafael Fonseca David H Vesole Michael E Williams Rafat Abonour David S Siegel Michael Katz Philip R Greipp | 2010 | Lancet Oncology2010，，1： | 2 |
| 3 | Transmission capacity: availability, maximum, transfer and reliability显示文摘 | Leite da S A M de Carvalho C J G da Fonseca M L A | 2002 | IEEE Transactions on Power Systems2002，17，3： | 1 |
| 4 | Nontraditional risk factors for cardiovascular disease in diabetes 显示文摘 | Fonseca V Desouza C Asnani S | 2004 | Endocrine Reviews2004，25，1： | 1 |
| 5 | Nontraditional risk factors for cardiovascular disease in diabetes显示文摘 | Fonseca V Desouzo C Asnani S | 2004 | Endocrine Reviews2004，25，： | 1 |
| 6 | Long-term probabilistic evaluation of operating reserve requirements with renewable sources显示文摘 | da SILVA A M L SALES W S da FONSECA MANSO L A | 2010 | IEEE Trans on Power Systems2010，25，1： | 1 |
| 7 | A lignan from needles of himalayan Taxus baccata 显示文摘 | Fonseca S F Nielsen T L Rhveda E A | 1978 | Phytochemistry1978，17，： | 1 |
| 8 | Surgical site infection: rates, etiology and resistance patterns to antimicrobials among strains isolated at Rio de Janeiro University Hospital显示文摘 | Santos K R Fonseca L S Bravo Neto G P | 1997 | Infection1997，25，4： | 1 |
| 9 | Discovering search engine related query using association rules显示文摘 | Fonseca B M Golgher P B Moura E S | | 0，，04： | 1 |
| 10 | Combined Interpolation Restoration of Land-sat Images Through FIR Filter Design Techniques显示文摘 | Fonseca L M G Prasad G S D Mascarenhas N D A | 1993 | International Journal of Remote Sensing1993，14，13： | 1 |
| 11 | FRP strengthened wood-frame roofs 显示文摘 | Judd Job_nn P Fonseca Femando S | 2003 | International SAMPE Symposium and Exhibition2003，，48： | 1 |
| 12 | Integrating biology and economics in seagrass restoration:How much is e- nough and why? 显示文摘 | FONSECA M S JULIUS B E KENWORTHY W J | 2000 | Ecological Engineering2000，15，34： | 1 |
| 13 | Ecological quality assessment of small estuaries from the Portuguese coast based on fish assemblages indices显示文摘 | Inês Cardoso Miguel Pessanha Pais Sofia Henriques Luís Cancela da Fonseca Henrique N. Cabral | 2011 | Marine Pollution Bulletin2011，，5： | 1 |
| 14 | The JAZ family of repressors is the missing link in jasmonate signaling显示文摘 | Chini A Fonseca S Fema'ndez G | 2007 | Nature2007，448，： | 1 |
| 15 | One-daily human Glp-1 analog liraglutide reduces systoic blood pressure-a meta analysis of six dinical trials(LEAD)显示文摘 | Fonseca V Madsbad S Falahati A | 2009 | Diabetes2009，58，1： | 1 |
| 16 | Detection of new art-4 and arr-5 gene cassettes in clinical Pseudomonas aerugi-nosa and Klebsiella pneumoniae strains from Brazil显示文摘 | da Fonseca EL Freitas Fdos S de Amorim JC | | 0，，05： | 1 |
| 17 | Plasma homocysteine concentrations are regulated by acute hyperinsulinemia in nondiabetic but not type 2 diabetic subjects显示文摘 | Fonseca VA Mudaliar S Srhmidt B | 1998 | Metabolism1998，47，： | 1 |
| 18 | Occur- rence and diversity of integrons and beta-lactarnase genes among ampicillin-resistant isolates from estuarine waters 显示文摘 | HENRIQUES I S FONSECA F ALVES A | 2006 | Res Microbiol2006，157，10： | 1 |
| 19 | FIDEL - a retrovirus -like retrotransposon and its distinct evolu- tlonary histories in the A - and B - genome components of cultivated peanut 显示文摘 | Nielen S Fonseca F C Bertioli S L | 2010 | Chromosome Research2010，18，： | 1 |
| 20 | Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity显示文摘 | Fonseca C Simoes S Gaspar R | 2002 | J Control Release2002，83，2： | 1 |
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