|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Novel genetic markers in inflammatory bowel disease显示文摘Genetic factors play a significant role in determining inflammatory bowel disease(IBD)susceptibility.Epidemiologic data support genetic contribution to the pathogenesis of IBD,which include familial aggregation,twin studies,racial and ethnic differences in disease prevalence.Linkage studies have identified several susceptibility genes contained in different genomic regions named IBD1 to IBD9.Nucleotide oligomerization domain(NOD2)and human leukocyte antigen(HLA)genes are the most extensively studied genetic regions(IBD1 and IBD3 respectively)in IBD.Mutations of the NOD2 gene are associated with Crohn's disease(CD)and several HLA genes are associated with ulcerative colitis(UC)and CD.Toll like receptors(TLRs)have an important role in the innate immune response against infections by mediating recognition of pathogen-associated microbial patterns.Studying single-nucleotide polymorphisms(SNPs)in molecules involved in bacterial recognition seems to be essential to define genetic backgrounds at risk of IBD.Recently,numerous new genes have been identified to be involved in the genetic susceptibility to IBD:NOD1/Caspase-activation recruitment domains 4(CARD4),Chemokine ligand 20(CCL20),IL-11,and IL-18 among others.The characterization of these novel genes potentially will lead to the identification of therapeutic agents and clinical assessment of phenotype and prognosis in patients with IBD. | Lorena Rodríguez-Bores Gabriela C Fonseca Marco A Villeda Jesús K Yamamoto-Furusho | 2007 | World Journal of Gastroenterology2007，13，42： | 8 |
| 2 | An overview of evolutionary algorithm in multi-objective optimization显示文摘 | Fonseca C M Fleming P J | 1995 | Evolutionary Computation1995，3，1： | 1 |
| 3 | An overview of evolutionary algorithms in multi-objective optimization显示文摘 | Fonseca C M Fleming P J | 1995 | Evolutionary Computation1995，3，1： | 1 |
| 4 | Transmission capacity: availability, maximum, transfer and reliability显示文摘 | Leite da S A M de Carvalho C J G da Fonseca M L A | 2002 | IEEE Transactions on Power Systems2002，17，3： | 1 |
| 5 | Therapeutic targets to reduce cardiovascular disease in type 2 diabetes 显示文摘 | DESOUZA C FONSECA V | 2009 | Nat Rev Drug Discov2009，8，： | 1 |
| 6 | Preparation and characterization of Carbon Nanotube/Polyacrylonitrile Composites显示文摘 | Pirlot C Willems I Fonseca A | 2002 | Adv Eng Mater2002，4，3： | 1 |
| 7 | Nontraditional risk factors for cardiovascular disease in diabetes 显示文摘 | Fonseca V Desouza C Asnani S | 2004 | Endocrine Reviews2004，25，1： | 1 |
| 8 | Nontraditional risk factors for cardiovascular disease in diabetes显示文摘 | Fonseca V Desouzo C Asnani S | 2004 | Endocrine Reviews2004，25，： | 1 |
| 9 | Using ontologies for integrated geographic information systems显示文摘 | Fonseca F Egenhofer M Agouris P Camara C | | 0，，03： | 1 |
| 10 | hnproved stability with intramedullary stem after anterior femoral notching in total knee arthroplasty 显示文摘 | Completo A Fonseca F Relvas C | 2012 | Knee Surg Sports Traumatol Arthrosc2012，20，3： | 1 |
| 11 | Receding forest edges and vanishing reserves显示文摘 | Gascon C Williamson G B da Fonseca G A B | 2000 | Science2000，288，： | 1 |
| 12 | Red blood cells promote survival and cell cycle progression of human peripheral blood T cells independently of CD58/LFA-3 and heme compounds显示文摘 | Fonseca A M Pereira C F Porto G | 2003 | Cellular Immunology2003，224，1： | 1 |
| 13 | Comparative value of BNP and NT-proBNP in diagnosis of heart failure 显示文摘 | Fonseca C Satmento PM Minez A | 2004 | Rev Port Cardiol2004，23，78： | 1 |
| 14 | Biodegradability enhancement of a leachate after biological lagooning using a solar driven photo-Fenton reaction,and further combination with an activated sludge biological process,at pre-industrial scale显示文摘 | Silva T F C V Fonseca A Saraiva I | 2013 | Water Research2013，47，10： | 1 |
| 15 | Multiobjective optimization and multiple constraint handling with evolutionary algo- rithms Part I: a unified formulation显示文摘 | FONSECA C M FLEMING P J | 1998 | IEEE Transactions on Systems Man and Cybernetics Part A:Systems and Hu- mans1998，28，1： | 1 |
| 16 | Targeting of stericallystabilised pH - sensitive liposomes to human T - leukaemia cells显示文摘 | Fonseca C Moreira JN Ciudad CJ | 2005 | Eur J Pharm Biopharm2005，59，2： | 1 |
| 17 | FIDEL - a retrovirus -like retrotransposon and its distinct evolu- tlonary histories in the A - and B - genome components of cultivated peanut 显示文摘 | Nielen S Fonseca F C Bertioli S L | 2010 | Chromosome Research2010，18，： | 1 |
| 18 | The remarkable Rhodococcus erythropolis显示文摘 | de Carvalho C C da Fonseca M M 2005 | 2005 | Appl Microbiol Biotechnol2005，67，： | 1 |
| 19 | Multiobjective optimization and multiple constraint handling with evolutionary algorithm Part Ⅱ:Application example显示文摘 | Fonseca C M Fleming P J | | 0，，： | 1 |
| 20 | Relationship between leptin and body mass and metabolic syndrome in an adult population显示文摘 | MARTINS MDO C LIMA FALEIRO L FONSECA A | 2012 | Rev Port Cardiol2012，31，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员