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| 1 | 多种基质金属蛋白酶在高氧所致急性肺损伤中的表达显示文摘目的探讨基质金属蛋白酶(MMPs)和细胞外基质金属蛋白酶诱导因子(EMMPRIN)在高氧所致急性肺损伤(ALI)发病中的作用。方法72只小鼠按随机数字表法分为正常对照组和高氧24、48、72h组,每组18只。高氧组小鼠置于密闭的氧气室,暴露于体积分数>98%的高氧;正常对照组小鼠呼吸室内空气作为对照组。分别于24、48和72h活杀高氧组小鼠,取肺评价肺损伤程度;逆转录聚合酶链反应(RT PCR)及免疫组化法测定肺组织MMP2、MMP9及EMMPRIN的mRNA和蛋白表达及组织分布。结果高氧能引起ALI。RT PCR结果显示,高氧组动物肺组织MMP2、MMP9及EMMPRIN的mRNA表达均增高;免疫组化研究显示,MMP2和MMP9蛋白主要表达于气道上皮细胞、血管平滑肌细胞和炎性细胞的胞浆中,EMMPRIN蛋白则主要表达于上述细胞胞浆和细胞膜上;它们在气道上皮细胞中的表达在高氧环境下明显升高。结论高氧能引起ALI,伴MMP2、MMP9和EMMPRIN的表达增高,MMPs通过降解细胞外基质从而在高氧所致ALI过程中发挥重要作用。 | 张向峰 丁少芳 高元明 梁瑛 Foda H D | 2006 | 中国危重病急救医学2006，18，8： | 17 |
| 2 | Osteopontin protects against hyperoxia-induced lung injury by inhibiting nitric oxide synthases显示文摘到超过 95% O_2 的成年老鼠的背景暴露到 72 个小时生产致命的损害。氮的氧化物 synthase (NOS ) 被认为贡献鼠科的导致 hyperoxia 的尖锐的肺损害(ALI ) 的 pathophysiology。Osteopontin (OPN ) 是巨噬细胞主要生产的 phosphorylated glycoprotein。OPN 禁止可诱导的氮的氧化物 synthase (iNOS ) ,它产生大量氮的氧化物生产。然而,在氮的氧化物之间的关系和在肺织物的内长的 OPN 还没在 导致hyperoxia 的 ALI 期间被阐明了,因此,我们检验了 OPN 在有 NOS.Methods 的 导致hyperoxia 的肺损害和它的关系起的作用 144 只 osteopontin 大美人(击倒)老鼠和他们的匹配的野类型背景控制( WT )在封上的笼子被暴露>为 24-72 小时的95%氧或房间空气,并且肺损害的严厉被估计;OPN 的表示, endothelial 氮的氧化物 synthase (eNOS ) 和在在 hyperoxia 的 24,48 和 72 个小时的肺纸巾的 iNOS mRNA 被反向的抄写聚合酶链反应(RT-PCR ) 学习;immunohistochemistry (IHC ) 被执行因为在肺 tissues.Results OPN 击倒老鼠的 iNOS, eNOS,和 OPN 蛋白质的察觉在 72 小时 hyperoxia 开发了更严重的尖锐的肺损害。湿 / 干燥的重量比率增加了到 6. | ZHANG Xiang-feng LIU Shuang ZHOU Yu-jie ZHU Guang-fa Hussein. D Foda | 2010 | Chinese Medical Journal2010，，7： | 4 |
| 3 | Low-density lipoprotein receptor genetic polymorphism in chronic hepatitis C virus Egyptian patients affects treatment response显示文摘AIM: To correlate a genetic polymorphism of the low-density lipoprotein(LDL) receptor with antiviral responses in Egyptian chronic hepatitis C virus(HCV) patients.METHODS: Our study included 657 HCV-infected patients with genotype 4 who received interferonbased combination therapy. Patients were divided into two groups based on their response to therapy: 356 were responders, and 301 were non-responders. Patients were compared to 160 healthy controls. All patients and controls underwent a thorough physical examination, measurement of body mass index(BMI) and the following laboratory tests: serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, albumin, total bilirubin, direct bilirubin, prothrombin time, prothrombin concentration, INR, complete blood count, serum creatinine, fasting blood sugar, HCV antibody, and hepatitis B surface antigen. All HCV patients were further subjected to the following laboratory tests: HCV-RNA using quantitative polymerase chain reaction(PCR), antinuclear antibodies, thyroid-stimulating hormone, an LDL receptor(LDLR) genotype study of LDLR exon8 c.1171G>A and exon-10 c.1413G>A using real-time PCR-based assays, abdominal ultrasonography, ultrasonographic-guided liver biopsy, and histopathological examination of liver biopsies. Correlations of LDL receptor polymorphisms with HAI, METAVIR score, presence of steatosis, and BMI were performed in all cases.RESULTS: There were no statistically significant differences in response rates between the different types of interferon used or LDLR exon10 c.1413G>A. However, there was a significant difference in the frequency of the LDL receptor exon8 c.1171G>A genotype between cases(AA: 25.9%, GA: 22.2%, GG: 51.9%) and controls(AA: 3.8%, GA: 53.1% and GG: 43.1%)(P < 0.001). There was a statistically significant difference in the frequency of the LDLR exon 8C:1171 G>A polymorphism between responders(AA: 3.6%, GA: 15.2%, GG: 81.2%) and nonresponders(AA: 52.2%, GA: 30.6%, GG: 17.2%)(P < 0.001). The G allele of LDL receptor exon8 c.1171G>A predominated in cases and controls over the A allele, and a statistically significant association with response to interferon was observed. The frequency of the LDLR exon8 c.1171G>A allele in non-responders was: A: 67.4% and G: 32.6 vs A: 11.2% and G: 88.8% in responders(P < 0.001). Therefore, carriers of the A allele exhibited a 16.4 times greater risk for nonresponse. There was a significant association between LDL receptors exon8 c.1171G>A and HAI(P < 0.011). There was a significant association between LDL receptors exon8 c.1171G>A and BMI. The mean BMI level was highest in patients carrying the AA genotype(28.7 ± 4.7 kg/m2) followed by the GA genotype(28.1 ± 4.8 kg/m2). The lowest BMI was the GG genotype(26.6 ± 4.3 kg/m2)(P < 0.001). The only significant associations were found between LDL receptors exon8 c.1171G>A and METAVIR score or steatosis(P < 0.001).CONCLUSION: LDL receptor gene polymorphisms play a role in the treatment response of HCV and the modulation of disease progression in Egyptiansinfected with chronic HCV. | Mazen Naga Mona Amin Dina Algendy Ahmed Elbadry May Fawzi Ayman Foda Serag Esmat Dina Sabry Laila Rashed Samia Gabal Manal Kamal | 2015 | World Journal of Gastroenterology2015，21，39： | 2 |
| 4 | Effect of fermentation the production of citric acid from cheese whey by aspergillus niger 显示文摘 | El-Samragy Y A Khorshid M A Foda M 1 | 1996 | International Journal of Food Microbiology1996，29，： | 1 |
| 5 | A new model of diffuse brain injury in rat: part Ⅰ: pathophysiology and biomechanics 显示文摘 | Foda AAA van den Brink W | 1994 | J Neurosurg1994，80，： | 1 |
| 6 | Matrix metalloproteinases in cancer invasion,metastasis and angiogenesis显示文摘 | Foda HD Zucker S | 2001 | DDT2001，6，9： | 1 |
| 7 | A boundary layer theory for Rayleigh waves in a porous fluid-filled half-space显示文摘 | Foda M A Mei C C | 1983 | Soil Dynamics and Earthquake Engineering1983，2，： | 1 |
| 8 | X-ray diffraction of starches isolated from yellow corn sorghum,sordan and pearlmillet显示文摘 | Allah M A Foda Y H Mahmoud R M | 1987 | Starch1987，39，2： | 1 |
| 9 | Involvement of both the V2 and V3 Regions of the CCR5-Tropic Human Immunodeficiency Virus Type 1 Envelope in Reduced Sensitivity to Macrophage Inflammatory Protein 1 α 显示文摘 | Maeda Y Foda M Matsushita S | 2000 | J Virol2000，74，： | 1 |
| 10 | A new model of diffuse brain injury in rats 显示文摘 | Foda MA Marmarou A | 1994 | J Neurosurg1994，80，： | 1 |
| 11 | A new model of diffuse brain injury in rats, Part I: pathophysiology and biomechanics 显示文摘 | Marmarou A Foda MA van dan Brink w | 1994 | J Neurosurg1994，80，2： | 1 |
| 12 | Novel fermentation media for production of -5-endotoxins from Bacillus thuringiensis显示文摘 | SALAMA H S FODA M S Dulmage H T | 1983 | J Invert Pathol1983，41，： | 1 |
| 13 | A new model of diffuse brain injury in rats,part1 and part2显示文摘 | Montasser A Abd-Elfattah Foda MS Marmarou A | 1994 | J Neurosurg1994，80，： | 1 |
| 14 | Hepatitis C virus infection in a community in the Nile Delta: Risk factors for seropositivity显示文摘 | Mostafa Habib Mostafa K. Mohamed Fatma Abdel-Aziz Laurence S. Magder Mohamed Abdel-Hamid Foda Gamil Salah Madkour Nabiel N. Mikhail Wagida Anwar G.Thomas Strickland Alan D. Fix Ismail Sallam | 2001 | Hepatology2001，，1： | 1 |
| 15 | Rhinoplasty in unilateral cleft lip nasal deformity显示文摘 | Foda HM Bassyouni K | 2000 | J Laryngol Otol2000，114，3： | 1 |
| 16 | A new model of diffuse brain injury in rats显示文摘 | Marmarou A Foda M A A Van den Brink W | 1994 | J Neurosurg1994，80，12： | 1 |
| 17 | Modification of rice starch by gamma irradiation to produce soluble starch of low viscosity for industrial purposes显示文摘 | SAADANY R M A El SAADANY F M El FODA Y H | 2006 | Starch Starke2006，，12： | 1 |
| 18 | Impact of schistosomiasis on quality of life and productivity of workers显示文摘 | Kamel MI Moustafa YA Foda N et aI | 2002 | East Mediterr Health J2002，8，23： | 1 |
| 19 | Matrix metalloproteinases in cancer invasion,metastasis and angiogenesis显示文摘 | Foda HD Zucker S | 2001 | Drug Discover Today2001，6，： | 1 |
| 20 | Septal perforation repair with acellular human dermalallograft 显示文摘 | Kridel RWH Foda H Lunde KC | 1998 | Arch Otolaryngol Head Neck Surg1998，124，： | 1 |
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