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| 1 | Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines显示文摘AIM To evaluate the treatment of osteonecrosis of the femoral head(ONFH) with the use of vascular endothelial growth factor(VEGF).METHODS In 30 mature beagles(6 groups of 5 beagles) ONFH was induced cryosurgically and one of the following solutions was administered locally in the femoral head(FH) in each group: Single injection of 500 μg VEGF(t-VEGFμ group); single injection of 500 ng VEGF(t-VEGFn group); continuous delivery of 500 μg VEGF through osmotic micropump(t-VEGFpump-μ group); continuous delivery of 500 ng VEGF through osmotic micropump(t-VEGFpump-n group); single injection of 0.9% sodium chloride(t-NS group), while one group that served as control group did not receive any local solution(No-t group). FHs were retrieved 12 wk postoperatively, underwent decalcification and hematoxylin/eosin and toluidine blue staining. In two canines per group, one half of FH was processed without decalcification and stained with modified Masson Trichrome. Histological sections were observed by light microscopy and measured with a semi-automatized bone histomorphometry system and Bone Volume/Total Volume(BV/TV), Marrow Volume/Total Volume(MaV/TV), and Trabecular Thickness(TbT h) were assessed. Standard and robust tests(Welch, Brown Forsythe) of analysis of variance along with multiple comparisons, were carried out among the categories.RESULTS The untreated(No-t) group had signs of osteonecrosis, whereas the VEGF groups revealed reversal of the osteonecrosis. Statistical analysis of the decalcified specimens revealed a significantly better BV/TV ratio and a higher Tb Th between the VEGF treatment groups(except the t-VEGFn group) and the No-t group or the control t-NS group. Single dose 500 μg VEGF group had significantly better BV/TV ratio and higher Tb Th when compared to the No-t group(50.45 ± 6.18 vs 29.50 ± 12.27, P = 0.002 and 151.44 ± 19.07 vs 107.77 ± 35.15, P = 0.161 respectively) and the control t-NS group(50.45 ± 6.18 vs 30.9 ± 6.67, P = 0.004 and 151.44 ± 19.07 vs 107.14 ± 35.71, P = 0.151 respectively). Similar differences were found for the prolonged VEGF delivery/pump groups of 500 μg and 500 ng. Analysis of the totality of specimens(decalcified/non-decalcified) enhanced the aforementioned differences and additionally revealed significant differences in the comparison of the TbT h.CONCLUSION In an experimental model of ONFH in canines it was found that local treatment with VEGF leads to bone tissue remodeling and new bone formation. | Zoe H Dailiana Nikolaos Stefanou Lubna Khaldi Georgios Dimakopoulos James R Bowers Cristian Fink James R Urbaniak | 2018 | World Journal of Orthopedics2018，9，9： | 13 |
| 2 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 3 | Neoadjuvant chemotherapy with cisplatin, 5-FU, and leucovorin (PLF) in locally advanced gastric cancer: a prospective phase II study显示文摘 | Katja Ott Andreas Sendler Karen Becker Hans-Joachim Dittler Hermann Helmberger Raimonde Busch Christian Kollmannsberger J. Rüdiger Siewert Ulrich Fink | 2003 | Gastric Cancer2003，，3： | 3 |
| 4 | Further geological and palaeoanthropological investigations at the Maludong hominin site, Yunnan Province, Southwest China显示文摘Three-dimensional mapping and section work undertaken by us in 2008 have identified 11 stratigraphic units at Maludong site.AMS radiocarbon dating of charcoal established an accurate and internally consistent age profile for the sequence of 17.8±0.2 ka to 13.2±0.1 ka.Archaeomagnetic analysis showed changes in externally derived pedogenically enhanced material consistent with a warming in climate between the cold period of Henrich Event 1 and the B lling-Aller d interstadial.Human remains recovered during the 1989 excavation were derived from a deposit dating to this interstadial,or between 14.3±0.3 ka and 13.5±0.1 ka.Anthropogenic features,including burnt rocks,baked sediment and thick charcoal and ash layers,were identified and examined through archaeomagnetic analysis.Two monkey fossils are described here,one of them being reassigned from Macaca robustus to M.aff.M.assamensis.They confirm the young age of the site and also show signs of anthropogenic alteration in the form of burning.Additional human cranial remains are reported for the first time and new data are provided for some specimens described previously.A range of new features is identified that strengthen the affinities of the Maludong remains to archaic humans.The presence of this globally unique mosaic of archaic and modern features raises important questions about human evolutionary history in East Asia during the Late Upper Pleistocene. | JI XuePing CURNOE Darren BAO ZhenDe HERRIES Andy I R FINK David ZHU YunSheng HELLSTROM John LUO Yun TACON Paul S C | 2013 | Chinese Science Bulletin2013，58，35： | 3 |
| 5 | Ploidy regulation of gene expression显示文摘 | Galitski T Saldanha A J Styles C A Lander E S Fink G R | 1999 | Science1999，285，： | 2 |
| 6 | Phase behavior of siloxane - based amphiphiles in supercritical carbon dioxide显示文摘 | FINK R BECKMAN E J | 2000 | Journal of Supercritical Fluids2000，18，： | 1 |
| 7 | A mechanism for transition-metal nanoparticle self-assembly显示文摘 | Besson C Finney E E Finke R G | 2005 | J Am Chem Soc2005，127，22： | 1 |
| 8 | Proinflammatory cytokines cause NO dependent and independent changes in expression and localization of tight junction proteins in intestinal epithelial cells显示文摘 | Han X Fink M P Delude R L | 2003 | Shock2003，19，3： | 1 |
| 9 | Effect of Added Asparagine and Glycine on Acrylamide Content in Yeast-Leavened bread显示文摘 | Fink M Andersson R Rosen J | 2006 | Cereal Chemistry2006，83，2： | 1 |
| 10 | An Assessment of Tele- communications Reform in Developing Countries 显示文摘 | Fink C Mattoo A Rathindran R | 2003 | Infor- mation Economics and Policy2003，15，4： | 1 |
| 11 | Analysis of Automatic Contingency Selection Algorithms显示文摘 | HALPIN T F FISCHI R FINK R | 1985 | 1EEE Transactions on Power Apparatus and Systems1985，103，5： | 1 |
| 12 | Nanocluster formation and stabilization fundamental studies:ranking commonly employed anionic stabilizers via the development,then application,of five comparative criteria显示文摘 | Ozkar S O Finke R G | 2002 | J Am Chem Soc2002，124，20： | 1 |
| 13 | Resistance to cytotoxic drugs in DNA mismatch repair-detcient cells clin显示文摘 | Aebi S Fink D Gordon R | 1997 | Cancer Res1997，3，： | 1 |
| 14 | Surgical treatment of child nevus 显示文摘 | Fink Puches R Soyer HP | 2000 | Eur J Surg2000，10，： | 1 |
| 15 | Tetramesityldisilene, a stable compound containing a silicon-silicon double bond显示文摘 | West R Fink M J Michl J | 1981 | Science1981，214，4527： | 1 |
| 16 | Transition-metal nanocluster kinetic and mechanistic studies emphasizing nanocluster agglomeration:demonstration of a kinetic method that allows monitoring of all three phases of nanocluster formation and aging显示文摘 | Hornstein B J Finke R G | 2004 | Chem Mater2004，16，1： | 1 |
| 17 | Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice显示文摘 | Han X Fink MP Yang R | 2004 | Shock2004，21，3： | 1 |
| 18 | Beta-sitosterol, a plant sterol, in-duces apoptosis and activates key ~'aspases in MDA-blB-231 hu-man breast cancer cells显示文摘 | Awad A B Roy R Fink C S | 2003 | Oncol Rep2003，10，： | 1 |
| 19 | Yeast plasma membrane ATPase is essential for growth and has homology with (Na^+┼K+) , K+ and Ca^2+-ATPase显示文摘 | Serrano R Kielland - Brandt M C Fink G R | 1986 | Nature1986，319，： | 1 |
| 20 | Hypercalcemic-type of small cell carcinoma of the ovary: characterization of a new tumor line 显示文摘 | Walt H Homung R Fink D | 2001 | Anticancer Res2001，21，5： | 1 |
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