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| 1 | Adipose tissue and vascular inflammation in coronary artery disease显示文摘Obesity has become an important public health issue in Western and developing countries,with well known metabolic and cardiovascular complications.In the last decades,evidence have been growing about the active role of adipose tissue as an endocrine organ in determining these pathological consequences.As a consequence of the expansion of fat depots,in obese subjects,adipose tissue cells develope a phenotypic modification,which turns into a change of the secretory output.Adipocytokines produced by both adipocytes and adipose stromal cells are involved in the modulation of glucose and lipid handling,vascular biology and,moreover,participate to the systemic inflammatory response,which characterizes obesity and metabolic syndrome.This might represent an important pathophysiological link with atherosclerotic complications and cardiovascular events.A great number of adipocytokines have been described recently,linking inflammatory mileu and vascular pathology.The understanding of these pathways is crucial not only from a pathophysiological point of view,but also to a better cardiovascular disease risk stratification and to the identification of possible therapeutic targets.The aim of this paper is to review the role of Adipocytokines as a possible link between obesity and vascular disease. | Enrica Golia Giuseppe Limongelli Francesco Natale Fabio Fimiani Valeria Maddaloni Pina Elvira Russo Lucia Riegler Renatomaria Bianchi Mario Crisci Gaetano Di Palma Paolo Golino Maria Giovanna Russo Raffaele Calabrò Paolo Calabrò | 2014 | World Journal of Cardiology2014，6，7： | 8 |
| 2 | 设计待机功耗仅为30mW的手机充电器显示文摘反激式电路结构通常用于低功率适配器的设计。在反激式设计中.市电输入在以高频开关之前将经由隔离变压器进行整流。对于这种设计结构.如果要求超高效率,设计师则会面临以下两大难题。首先,在恒流模式下.必须可以检测到负载电流并将反馈信号传送到初级侧;但是, | Silvestro Fimiani | 2009 | 电子设计技术 EDN CHINA2009，，12： | 2 |
| 3 | 单级功率因数校正LED驱动器显示文摘引言
新的能源之星LED驱动器法规要求家用产品的功率因数(PF)达到0.7或更高,要求商用产品的功率因数(PF)达到0.9。本文将介绍一款适用于LED驱动器的极具成本效益的单级功率因数校正(PFC)电路,采用Power Integrations公司的TOPSwitch-Gx系列产品TOP259YN设计而成。本设计采用单级方法,可降低驱动器成本并提高效率。 | Silvestro Fimiani | 2008 | 电子设计应用2008，，9： | 2 |
| 4 | 充分发挥LED照明的能效优势显示文摘在LED照明产业发展对LED驱动器设计的要求日益提高的背景下,本文提出了可满足应用需求的LED驱动器解决方案LinkSwitch-Ⅱ系列,并对其电路设计中的优越性进行了说明。 | Silvestro Fimiani | 2009 | 电子设计应用2009，，6： | 2 |
| 5 | NF-kappaB,nitric oxide and opiate signaling 显示文摘 | WELTERS I D FIMIANI C BILFINGER T V | 2000 | MedHypotheses2000，54，2： | 1 |
| 6 | UVA light stimulates the production of cathepsin G and elastase-like enzymes by dermal fibroblasts:a possible contribution to the remodeling of elastotic areas in sun-damaged skin显示文摘 | Cavarra E Fimiani M Lungarella G | 2002 | Biol Chem2002，383，1： | 1 |
| 7 | Management of chronic heart failure:Role of home echocardiography in monitoring care programs显示文摘AIM:To identify a possible role of home echocardiography for monitoring chronic heart failure(CHF)patients.METHODS:We prospectively investigated 118 patients hospitalized during the last year for CHF who could not easily reach the pertaining District Healthcare Center.The patients were followed up with 2 home management programs:one including clinical and electrocardiographic evaluations and also periodic home echocardiographic examinations(group A),the other including clinical and electrocardiographic evaluations only(group B).RESULTS:At the end of the 18-mo follow-up no significant differences were observed between the 2 groups as regards the primary endpoint:rehospitalization occurred in 4 patients of the group A and in 6 patients of the group B;major cardiovascular events occurred in 2 and in 3 patients,respectively.No significant differences were observed with respect to the secondary endpoints:one vascular event appeared in both the groups,3 cardiovascular deaths occurred in group A and 2 in group B.No significant differences were observed between the 2 groups as regards the composite endpoint of death plus hospitalization.CONCLUSION:Home echocardiography for monitoring of CHF patients does not improve the cardiovascular endpoints.In our CHF patients,a low incidence of vascular events was observed. | Silvia Soreca Sergio Aprile Andrea Cardone Giovanni Carella Biagio Fimiani Franco Guarnaccia Giosuè Santoro Valentina Apuzzi Giorgio Bosso Antonio Valvano Giovanni Zito Ugo Oliviero | 2012 | World Journal of Cardiology2012，4，3： | 1 |
| 8 | Morphine's immunoregulatory actions are not shared by fentanyl显示文摘 | Bitfinger TV Fimiani C Stefano GB | 1998 | Int J Cardiol1998，64，1： | 1 |
| 9 | NF-κB,nitric oxide and opiate signaling显示文摘 | WELTERS ID FIMIANI C BIFINGER TV | 2000 | Med Hypothese2000，54，2： | 1 |
| 10 | NF-kappaB,nitric oxide and opiate signaling 显示文摘 | WELTERS I D FIMIANI C BILFINGER T V | 2000 | MedHypotheses2000，54，2： | 1 |
| 11 | Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model显示文摘 | Paolo Sbano Aldo Cuccia Benedetta Mazzanti Serena Urbani Betti Giusti Ilaria Lapini Luciana Rossi Rosanna Abbate Giuseppina Marseglia Genni Nannetti Francesca Torricelli Clelia Miracco Alberto Bosi Michele Fimiani Riccardo Saccardi | 2008 | Archives of Dermatological Research2008，，3： | 1 |
| 12 | Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation显示文摘 | Fusco F Bardaro T Fimiani G | 2004 | Hum Mol Genet2004，13，16： | 1 |
| 13 | Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-κB activation显示文摘 | Fusco F Bardaro T Fimiani G | 2004 | Hum MolGenet2004，13，16： | 1 |
| 14 | Thirty-six caces of epidemic infec- tions due to Trichopbyton violtweum in Siena, llaly 显示文摘 | Romano C Feci L Fimiani M | 2012 | Mycoses2012，55，2： | 1 |
| 15 | Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF - kB activation 显示文摘 | Fusco F Bardaro T Fimiani G | 2004 | Hum Mol Genet2004，13，16： | 1 |
| 16 | The use of terlipressin in cir- rhotic patients with refractory ascites and normal renal function : a multicentric study 显示文摘 | Fimiani B Guardia DD Puoti C et at | 2011 | Eur J Intern Med2011，22，： | 1 |
| 17 | Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience显示文摘AIM: To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. METHODS: This study was a non-randomized, observational, prospective, multicenter. This study involved 47 centers in Italy. A database was prepared for the homogenous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was performed using COBAS-Taq Man2.0(Roche, LLQ 25 IU/m L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: Male 64%; median age 57(range 18-78), of whom 18.3% were over 65; mean body mass index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatment. Anemia was the most frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has moderate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin. | Antonio Ascione Luigi Elio Adinolfi Pietro Amoroso Angelo Andriulli Orlando Armignacco Tiziana Ascione Sergio Babudieri Giorgio Barbarini Michele Brogna Francesco Cesario Vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adamo Emilio D’Amico Pellegrino Dattolo Massimo De Luca Vincenzo De Maria Massimo De Siena Giuseppe De Vita Antonio Di Giacomo Rosanna De Marco Giorgio De Stefano Giulio De Stefano Sebastiano Di Salvo Raffaele Di Sarno Nunzia Farella Laura Felicioni Basilio Fimiani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulminetti Angelo Iacobellis Michele Imparato Angelo Iodice Vincenzo Iovinella Antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo Marrone Ettore Mazzoni Vincenzo Messina Roberto Monarca Vincenzo Narciso Lorenzo Nosotti Adriano Maria Pellicelli Alessandro Perrella Guido Piai Antonio Picardi Paola Pierri Grazia Pietromatera Francesco Resta Luca Rinaldi Mario Romano Angelo Rossini Maurizio Russello Grazia Russo Rodolfo Sacco Vincenzo Sangiovanni Antonio Schiano Antonio Sciambra Gaetano Scifo Filomena Simeone Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone | 2016 | World Journal of Hepatology2016，8，22： | 1 |
| 18 | Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-κB activation显示文摘 | Fusco F Bardaro T Fimiani G | 2004 | Hum Mol Genet2004，13，16： | 1 |
| 19 | The structureof human STAT5 A and B genes reveals two regions ofnearly identical sequence and an alternative tissue specificSTAT5B promoter显示文摘 | Ambrosio R Fimiani G Monfregola J | 2002 | Gene2002，285，12： | 1 |
| 20 | Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model显示文摘 | Paolo Sbano Aldo Cuccia Benedetta Mazzanti Serena Urbani Betti Giusti Ilaria Lapini Luciana Rossi Rosanna Abbate Giuseppina Marseglia Genni Nannetti Francesca Torricelli Clelia Miracco Alberto Bosi Michele Fimiani Riccardo Saccardi | 2008 | Archives of Dermatological Research2008，，3： | 1 |
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