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| 1 | Sublingual immunotherapy for pediatric allergic rhinitis: The clinical evidence显示文摘Allergic rhinitis affect 10%-20% of pediatric population and it is caused by the Ig E-sensitization to environmental allergens, most importantly grass pollens and house dust mites. Allergic rhinitis can influence patient's daily activity severely and may precede the development of asthma, especially if it is not diagnosed and treated correctly. In addition to subcutaneous immunotherapy, sublingual immunotherapy(SLIT) represents the only treatment being potentially able to cure allergic respiratory diseases, by modulating the immune system activity. This review clearly summarizes and analyzes the available randomized, double-blinded, placebo-controlled trials, which aimed at evaluating the effectiveness and the safety of grass pollen and house dust mite SLIT for the specific treatment of pediatric allergic rhinitis. Our analysis demonstrates the good evidence supporting the efficacy of SLIT for allergic rhinitis to grass pollens in children, whereas trials regarding pediatric allergic rhinitis to house dust mites present lower quality, although several studies supported its usefulness. | Dimitri Poddighe Amelia Licari Silvia Caimmi Gian Luigi Marseglia | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 7 |
| 2 | Gastroesophageal reflux and congenital gastrointestinal malformations显示文摘Although the outcome of newborns with surgical congenital diseases(e.g.,diaphragmatic hernia;esophageal atresia;omphalocele;gastroschisis) has improved rapidly with recent advances in perinatal intensive care and surgery,infant survivors often require intensive treatment after birth,have prolonged hospitalizations,and,after discharge,may have longterm sequelae including gastro-intestinal comorbidities,above all,gastroesophageal reflux(GER).This condition involves the involuntary retrograde passage of gastric contents into the esophagus,with or without regurgitation or vomiting.It is a well-recognized condition,typical of infants,with an incidence of 85%,which usually resolves after physiological maturation of the lower esophageal sphincter and lengthening of the intra-abdominal esophagus,in the first few months after birth.Although the exact cause of abnormal esophageal function in congenital defects is not clearly understood,it has been hypothesized that common(increased intra-abdominal pressure after closure of the abdominal defect) and/or specific(e.g.,motility disturbance of the upper gastrointestinal tract,damage of esophageal peristaltic pump) pathological mechanisms may play a role in the etiology of GER in patients with birth defects.Improvement of knowledge could positively impact the long-term prognosis of patients with surgical congenital diseases.The present manuscript provides a literature review focused on pathological and clinical characteristics of GER in patients who have undergone surgical treatment for congenital abdominal malformations. | Lucia Marseglia Sara Manti Gabriella D'Angelo Eloisa Gitto Carmelo Salpietro Antonio Centorrino Gianfranco Scalfari Giuseppe Santoro Pietro Impellizzeri Carmelo Romeo | 2015 | World Journal of Gastroenterology2015，21，28： | 3 |
| 3 | Role of the diet as a link between oxidative stress and liver diseases显示文摘Oxidative stress is caused by an imbalance between the production of reactive oxygen(free radicals) and the body's ability(antioxidant capacity) to readily detoxify the reactive intermediates or easily repair the resulting damage. An adequate diet, characterized by daily intake of foods associated with improvementsin the total antioxidant capacity of individuals and reduced incidence of diseases related to oxidation, can modulate the degree of oxidative stress. In fact, dietderived micronutrients may be direct antioxidants, or are components of antioxidant enzymes, leading to improvement of some indicators of hepatic function. However, although their increased dietary intake might be beneficial, literature data are still controversial. This review summarizes what is known about the effects of diet nutrients on oxidative stress, inflammation and liver function. Moreover, we have analyzed:(1) the main nutritional components involved in the production and/or removal of free radicals; and(2) the role of free radicals in the pathogenesis of several hepatic diseases and related comorbidities. | Teresa Arrigo Salvatore Leonardi Caterina Cuppari Sara Manti Angela Lanzafame Gabriella D'Angelo Eloisa Gitto Lucia Marseglia Carmelo Salpietro | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 4 | Safety of sublingual immu- notherapy显示文摘 | Ciprandi G Marseglia G L | 2011 | J Biol Regul Homeost Agents2011，25，1： | 1 |
| 5 | Serum IL -9 le- vels and sublingual immunotherapy: preliminary report显示文摘 | CIPRANDI G AMICI M D MARSEGLIA G L | 2011 | J Biol Regul Homeost Agents2011，25，2： | 1 |
| 6 | Increased risk of otitis media with effusion in allergic children presenting with adenoiditis 显示文摘 | Marseglia GL Pagella F Caimmi D | 2008 | Otolaryngology Head and Neck Surgery2008，138，04： | 1 |
| 7 | Serum Interleukin‐9 Levels Are Associated With Clinical Severity in Children With Atopic Dermatitis显示文摘 | Giorgio Ciprandi Mara De Amici Vania Giunta Alessia Marseglia Gianluigi Marseglia | 2012 | Pediatric Dermatology2012，，2： | 1 |
| 8 | Oxidative stress in obesity : A critical component in human diseases 显示文摘 | Marseglia L Manti S D'Angelo G | 2014 | Int J Mol Sei2014，16，1： | 1 |
| 9 | Immunoactivation by pidotimod in children with recurrent respiratory infections显示文摘 | Burgio GR Marseglia GL Severi F | 1994 | Arzneimittelforsch1994，44，12： | 1 |
| 10 | Immunoactivation by pidotimod in children with recurrent respiratory infections 显示文摘 | Burgio GR Marseglia GL Severi F | 1994 | Arzneimittelforschung1994，44，12： | 1 |
| 11 | Electron trapping in dye/polymer blen photovoltaic cells 显示文摘 | Dittmer J J Marseglia E A Friend R H | 2000 | Adv Mater2000，12，17： | 1 |
| 12 | Role of forced expiratory flow at 25 % - 75 % as an early marker of small airways impairment in subjects with allergic rhinitis 显示文摘 | Marseglia GL Cirillo I Vizzaccaro A | 2007 | Al- lergy Asthma Proc2007，28，1： | 1 |
| 13 | Serum alpha-fetoprotein (AFP) levels in breastfed infants with prolonged indirecthyperbilirubinemia显示文摘 | Manganaro R Marseglia L Mamì C | | 0，，07： | 1 |
| 14 | A low- temperature structural phase transition in 13-MoTez 显示文摘 | CLARKE R MARSEGLIA E HUGHES H P | 1978 | Philosophical Magazine Part: B1978，38，2： | 1 |
| 15 | Immunoactivation by Pidotinod in Children with Recurrent Respiratory Infections显示文摘 | Burgio G R Marseglia G L Severi F | 1994 | Arzneimitte l- Forsc hung1994，44，12： | 1 |
| 16 | Dye-based donor/acceptor solar cells 显示文摘 | Petritsch K Dittmer J J Marseglia E A | 2000 | Solar Energy Materials and Solar Cells2000，61，： | 1 |
| 17 | Inhalation therapy in asthmatic and not asthmatic children 显示文摘 | Lo Valvo L Leonardi S Marseglia G L | 2011 | Int J lmmunopathol Pharmaco12011，24，4： | 1 |
| 18 | Application of I H NMR for the characterisation of cocoa beans of different geographical origins and fermentation levels 显示文摘 | Caligiani A Palla L Aequotti D Marseglia A Palla G | 2014 | Food Chemistry2014，157，： | 1 |
| 19 | Comparison ofserum specific IgE and skin prick test in polysensitized patients显示文摘 | Ciprandi G De Amici M Giunta V Marseglia GL | 2010 | Int J Immunopathol Pharmacol2010，23，4： | 1 |
| 20 | Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model显示文摘 | Paolo Sbano Aldo Cuccia Benedetta Mazzanti Serena Urbani Betti Giusti Ilaria Lapini Luciana Rossi Rosanna Abbate Giuseppina Marseglia Genni Nannetti Francesca Torricelli Clelia Miracco Alberto Bosi Michele Fimiani Riccardo Saccardi | 2008 | Archives of Dermatological Research2008，，3： | 1 |
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