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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Insulin signaling in os-teoblasts integrates bone remodeling and energy metabolism显示文摘 | FERRON M WEI J YOSHIZAWA T | | 0，，02： | 1 |
| 3 | 查看详情显示文摘 | Gohil P Evans T E Ferron J R Moyer R A Petty C C Burrell K H Casper T A Garofalo A M Hyatt A W Jayakumar R J Kessel C Kim J Y La Haye R J Lohr J Luce T C Makowski M A Mazon D Menard J Murakami M Politzer P A Prater R Wade M R | | 0，，： | 1 |
| 4 | Perioperative C19 -9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma 显示文摘 | Ferrone C R Finkelstein D M Thayer S P | 2006 | J Clin Oncol2006，24，18： | 1 |
| 5 | Pharmacokinetics and Safety of Tanaproget,a Nonsteroidal Progesterone Receptor Agonist,in Healthy Women显示文摘 | Bapst J L Ermer J C Ferron G M | | 0，，： | 1 |
| 6 | The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum显示文摘 | Fang S Ferrone M Yang C | 2001 | Proc Natl Acad Sci U S A2001，98，14： | 1 |
| 7 | Functional and clinical relevance of chondroitin sulfate proteoglycan 4显示文摘 | CAMPOLI M FERRONE S WANG X | 2010 | Adv Cancer Res2010，109，： | 1 |
| 8 | Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual显示文摘 | Kajimura D Hinoi E Ferron M | 2011 | J Exp Med2011，208，： | 1 |
| 9 | Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism显示文摘 | Ferron M Wei J Yoshizawa T | 2010 | Cell2010，142，： | 1 |
| 10 | Regulation of energy metabolism by the skeleton: osteocalcin and beyond显示文摘 | Ferron M Lacombe J | 2014 | Arch Biochem Biophys2014，561，： | 1 |
| 11 | Intermittent in-jections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice显示文摘 | FERRON M MC KEE MD LEVINE RL | 2012 | Bone2012，50，2： | 1 |
| 12 | Osteoealcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice显示文摘 | Ferron M Hinoi E Karsenty G | 2008 | Proc Natl Acad Sci USA2008，105，： | 1 |
| 13 | Osteocalcin differ- entially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice显示文摘 | Ferron M Hinoi E Karsenty G | 2008 | Proc Natl Acad Sci U S A2008，105，13： | 1 |
| 14 | Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice显示文摘 | Ferron M Mckee MD Levine RL | 2012 | Bone2012，50，： | 1 |
| 15 | Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism显示文摘 | Ferron M Wei J Yoshizawa T | 2010 | Cell2010，142，2： | 1 |
| 16 | Insulin signaling in osteoblasts integrates bone remodeling and energy metabo- lism显示文摘 | Ferron M Wei J Yoshizawa T | 2010 | Cell2010，142，2： | 1 |
| 17 | Gamma- linolenic acid from fourteen Boraginaceae species 显示文摘 | GUIL- GUERRERO J L GARCFA - MAROTO F VILCHES- FERRON M A | 2003 | Ind Crop Prod2003，18，1： | 1 |
| 18 | Removal of ethmoidal malig-nant tumors by the isolated paralateronasal approach with resection of the cribriform plate and the dura mater显示文摘 | Faure A Ferron C Khalfallah M | 2003 | Surg Neurol2003，60，5： | 1 |
| 19 | An ELISA-based method to quantify osteocalcin carboxylation in mice 显示文摘 | Ferron M Wei J Yoshizawa T | 2010 | Biochem Biophys Res Commun2010，397，4： | 1 |
| 20 | Immunotherapy of malig- nant disease with tumor antigenspecifi c monoclonal antibodies 显示文摘 | Campoli M Ferris R Ferrone S | 2010 | Clin Cancer Res2010，16，： | 1 |
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