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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 3 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Helen M Fernandes Gordon D Murray Graham M Teasdale D Terence Hope Abbas Karimi M Donald M Shaw David H Barer | 2005 | 2005 (9457)2005，，9457： | 2 |
| 4 | Prepara- tion and characterization of foams from sheet glass and fly ash using carbonates as foaming agents 显示文摘 | Fernandes H R Tulyaganov D U Ferreira J M F | 2009 | Ceram Int2009，35，1： | 1 |
| 5 | Regulatory role of T cells in a murine model of lymphoproliferative disease 显示文摘 | Raveche E Fernandes H Ong H | 1998 | Cellular Immunology1998，187，： | 1 |
| 6 | Improvements for mass-exchange networks design 显示文摘 | Castro P Matos H Fernandes M C | 1999 | Chemical Engineering Science1999，54，： | 1 |
| 7 | Heavy metal distribution in sediments and ecological risk assessment: the role of diagenetic process- es in deducing metal toxicity in bottom sediments显示文摘 | FERNANDES H M | 1997 | Environ Pollut1997，97，： | 1 |
| 8 | Immobilization of naringinase in PVA-alginate matrix using an innovative technique显示文摘 | Nunes MAP Vila-Real H Fernandes PCB | | 0，，07： | 1 |
| 9 | Environmental friendly management of CRT glass by foaming with waste egg shells, calcite or dolomite 显示文摘 | Fernandes H R Ferreira D D Andreola F | 2014 | Ceramics International2014，40，13： | 1 |
| 10 | Synthesis and characterization of novel chiral ionic liquids and investigation of their enantiomeric recognition properties显示文摘 | Bwambok D K Marwani H M Fernand V E | 2008 | Chirality2008，20，： | 1 |
| 11 | A unified periodical boundary conditions for representative volume elements of composites and applications 显示文摘 | Xia Z H Zhang Y F Fernand E | 2003 | International Journal of Solid & Structure2003，40，8： | 1 |
| 12 | Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial显示文摘 | A David Mendelow Barbara A Gregson Helen M Fernandes Gordon D Murray Graham M Teasdale D Terence Hope Abbas Karimi M Donald M Shaw David H Barer | 2005 | The Lancet2005，，9457： | 1 |
| 13 | Prostatic arterialembo- lization : post - procedural follow - up显示文摘 | Fernandes L Rio Tinto H Pereira J | 2012 | Teeh Vasc Interv Ra- dio12012，15，： | 1 |
| 14 | Incorporated tool selection sys-tem using object technology显示文摘 | Fernandes K J Raja V H | 2000 | International Journal ofMachine Tools&Manufacture2000，40，： | 1 |
| 15 | A unified periodical boundary conditions for representative volume elements of composites and applications 显示文摘 | Xia Z H Zhang Y F Fernand E | 2003 | International Journal of Solid Structure2003，40，8： | 1 |
| 16 | Diamond Coating on Steel with a Titanium Interlayer显示文摘 | Fan Q H Fernandes A Gracio J | 1998 | Diamond and Related Materi- als1998，7，2： | 1 |
| 17 | High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin 43 by a proteasome-dependent mechanism显示文摘 | Fernandes R Girao H Pereira P | 2004 | J Biol Chem2004，279，27： | 1 |
| 18 | Characterization of the triplet state of tris( 8-hydro xyquinoline)aluminlum(III) in benzene solution显示文摘 | Burrows H D Fernandes M Seixas de Melo J | 2003 | J Am Chem Soc2003，125，15： | 1 |
| 19 | Optimisation of the biological treatment of hypersaline wastewater from Dunaliella salina carotenogenesis 显示文摘 | Santos C A Vieira A M Fernandes H L | 2001 | J Chem Technol Biotechnol2001，76，11： | 1 |
| 20 | Effects of Si speciation on the in vitro evaluation of bioactivity of glasses显示文摘 | OLIVERIRA J M CORREIA R N FERNANDES M H | 2002 | Biomaterials2002，23，2： | 1 |
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