|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes显示文摘AIM To detect human papilloma virus(HPV) presence and to characterize cellular immune response in breast cancer patients. METHODS A total of 74 women were included, of which 48 samples were from patients diagnosed with breast cancer and 26 patients with benign pathology of the breast. Molecular subtype classification was performed based on the immunohistochemical reports of the tumor piece. HPV genome detection and genotyping from fresh breast biopsies was performed using the INNO-LIPA HPV Genotyping Extra test(Innogenetics, Ghent, Belgium). CD3+, CD4+, CD8+ and natural killer(NK)+ cells levels from peripheral blood samples from patients with breast cancer and benign pathology were measured by flow cytometry. RESULTS Luminal A was the most frequent breast cancer molecular subtype(33.33%). HPV was detected in 25% of the breast cancer patients, and genotype 18 was the most frequent in the studied population. The mean of CD3+, CD4+ and CD8+ subpopulations were decreased in patients with breast cancer, in relation to those with benign pathology, with a statistically significant difference in CD8+ values(P = 0.048). The mean of NK+ cells was increased in the benign pathology group. The average level of CD3+, CD4+, CD8+ and NK+ cells decreased as the disease progressed. HER2+ and Luminal B HER2+ tumors had the lowest counts of cell subsets. HPV breast cancer patients had elevated counts of cellular subsets. CONCLUSION Determining level changes in cellular subsets in breast cancer patients is a useful tool to evaluate treatment response. | Andreína Fernandes Adriana Pesci-Feltri Isabel García-Fleury Marco López Vincent Guida Marisol De Macedo María Correnti | 2018 | World Journal of Clinical Oncology2018，9，7： | 5 |
| 2 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 3 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 4 | European indoor air quality audit project in 56 office buildings显示文摘 | BLUYSSEN P M de Oloveira Fernandes E GROES L | 1996 | Indoor Air1996，，6： | 2 |
| 5 | Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder显示文摘 | Brietzke E Stertz L Fernandes BS | 2009 | J Affect Disord2009，116，3： | 1 |
| 6 | Effects of herbivory by Hyblaea puera ( Hyblaeidae : Lepidop- tera) on litter production in the mangrove on the coast of Brazi- lian Amazonia显示文摘 | FERNANDES M E B NASCIMENTO A A M CARVALHO M L | 2009 | Journal of Tropical Ecology2009，25，3： | 1 |
| 7 | Spontaneous recurrent seizures in rats:Amino acid and monoamine determination in the hippocampus显示文摘 | Cavalheiro EA Fernandes MJ Turski L | 1994 | Epilepsia1994，35，1： | 1 |
| 8 | Hydrolysis and synthesis reactions catalysed by Thermomyces lanuginosa lipase in the AOT/Isooctane reversed micellar system 显示文摘 | Fernandes M L M Krieger N Baron A M | 2004 | J Mol Catal B : Enzym2004，30，1： | 1 |
| 9 | Non-enzymatic browning in clarified cashew apple juice during thermal treatment:kinetics and process control显示文摘 | DAMASCENO L F FERNANDES FAN MAGALHAES M | 2008 | Food Chemistry2008，106，1： | 1 |
| 10 | Decomposition and stabilization of organic matter in an old-growth tropical riparian forest:effects of soil properties and vegetation structure显示文摘Background:Nutrient cycling in tropical forests has a large importance for primary productivity,and decomposition of litterfall is a major process influencing nutrient balance in forest soils.Although large-scale factors strongly influence decomposition patterns,small-scale factors can have major influences,especially in old-growth forests that have high structural complexity and strong plant-soil correlations.Here we evaluated the effects of forest structure and soil properties on decomposition rates and stabilization of soil organic matter using the Tea Bag Index(TBI)in an old-growth riparian forest in southeastern Brazil.These data sets were described separately using Principal Components Analysis(PCA).The main axes for each analysis,together with soil physical properties(clay content and soil moisture),were used to construct structural equations models that evaluated the different parameters of the TBI,decomposition rates and stabilization factor.The best model was selected using Akaike’s criterion.Results:Forest structure and soil physical and chemical properties presented large variation among plots within the studied forest.Clay content was strongly correlated with soil moisture and the first PCA axis of soil chemical properties,and model selection indicated that clay content was a better predictor than this axis.Decomposition rates presented a large variation among tea bags(0.009 and 0.098 g·g^(−1)·d−1)and were positively related with forest structure,as characterized by higher basal area,tree density and larger trees.The stabilization factor varied between 0.211–0.426 and was related to forest stratification and soil clay content.Conclusions:The old-growth forest studied presented high heterogeneity in both forest structure and soil properties at small spatial scales,that influenced decomposition processes and probably contributed to small-scale variation in nutrient cycling.Decomposition rates were only influenced by forest structure,whereas the stabilization factor was influenced by both forest structure and soil properties.Heterogeneity in ecological processes can contribute to the resilience of old-growth forests,highlighting the importance of restoration strategies that consider the spatial variation of ecosystem processes. | Pedro Henrique de Godoy Fernandes Andréa Lúcia Teixeira de Souza Marcel Okamoto Tanaka Renata Sebastiani | 2021 | Forest Ecosystems2021，8，1： | 1 |
| 11 | Scandium in aluminum alloys 显示文摘 | KRAMER L S TACK W T FERNANDES M T | 1997 | Adv Mater Process1997，152，10： | 1 |
| 12 | Influence of parasitism by piloslyles ingae(Rafflesiaceae)on its host plant,Mimosanaguirei(Leguminosae)显示文摘 | Gomes A L Fernandes G W | 1994 | Ann Bot1994，74，： | 1 |
| 13 | Photochemical processes and the environmental impact of petroleum spills 显示文摘 | Nicodem D E Fernandes M C Z Guedes C L B | 1997 | Biogeochemistry1997，39，： | 1 |
| 14 | Effects of plough pan development on surface hydrology and on soil physical properties in Southeastern Brazilian pla- teau显示文摘 | Bertolino Aria V F A Fernandes N F Miranda J P L | 2010 | J Hydro2010，393，12： | 1 |
| 15 | Prostatic arterialembo- lization : post - procedural follow - up显示文摘 | Fernandes L Rio Tinto H Pereira J | 2012 | Teeh Vasc Interv Ra- dio12012，15，： | 1 |
| 16 | Angioten sin(1-7) antagonist A-779 attenuates the potentiation of bra dykinin by captopril in rats 显示文摘 | MAIA L G RAMOS M E FERNANDES L | 2004 | J Cardiovasc Pharmacol2004，43，： | 1 |
| 17 | A Rac homolog functions downstream of Rasl to control hyphal differentiation and high-temperature growth in the pathogenic fungus Cryptococcus neoformans显示文摘 | Vallim M A Nichols C B Fernandes L | 2005 | Eukaryotic Cell2005，4，6： | 1 |
| 18 | A new framework for complex wavelet transforms 显示文摘 | FERNANDES F A VAN SPAENDONCK R L C | 2003 | IEEE Trans Signal Processing2003，51，7： | 1 |
| 19 | Treatment of human monocytes with interleukin(IL)-18 increases TLR4 and mannose receptor expression and modulates cytokine production显示文摘 | Dias-Melicio L A Fernandes R K Golim M A | | 0，，1： | 1 |
| 20 | Optimisation of the biological treatment of hypersaline wastewater from Dunaliella salina carotenogenesis 显示文摘 | Santos C A Vieira A M Fernandes H L | 2001 | J Chem Technol Biotechnol2001，76，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员