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| 1 | Upregulation of the APE1 and H2AX genes and miRNAs involved in DNA damage response and repair in gastric cancer显示文摘Gastric cancer remains one of the leading causes of cancer-related death worldwide,and most of the cases are associated with Helicobacter pylori infection.This bacterium promotes the production of reactive oxygen species(ROS),which cause DNA damage in gastric epithelial cells.In this study,we evaluated the expression of important genes involved in the recognition of DNA damage(ATM,ATR,and H2AX)and ROS-induced damage repair(APE1)and the expression of some miRNAs(miR-15a,miR-21,miR-24,miR-421 and miR-605)that target genes involved in the DNA damage response(DDR)in 31 fresh tissues of gastric cancer.Cytoscape v3.1.1 was used to construct the postulated miRNA:mRNA interaction network.Analysis performed by real-time quantitative PCR exhibited significantly increased levels of the APE1(RQ=2.55,p<0.0001)and H2AX(RQ=2.88,p=0.0002)genes beyond the miR-421 and miR-605 in the gastric cancer samples.In addition,significantly elevated levels of miR-21,miR-24 and miR-421 were observed in diffuse-type gastric cancer.Correlation analysis reinforced some of the gene:gene(ATM/ATR/H2AX)and miRNA:mRNA relationships obtained also with the interaction network.Thus,our findings show that tumor cells from gastric cancer presents deregulation of genes and miRNAs that participate in the recognition and repair of DNA damage,which could confer an advantage to cell survival and proliferation in the tumor microenvironment. | Fernanda S.Manoel-Caetano Ana Flávia T.Rossi Gabriela Calvet de Morais Fábio Eduardo Severino Ana Elizabete Silva | 2019 | Genes & Diseases2019，6，2： | 5 |
| 2 | Modeling respiration rate of fresh fruits and vegetable for modified atmosphere packages: a review显示文摘 | Susana C F Fernanda A R Jeffrey K B | 2002 | Journal of Food Engineering2002，52，6： | 1 |
| 3 | Modeling res- piration rate of shredded Galena kale for development of modi- fied atmosphere packaging 显示文摘 | Susana C F Fernanda A R O Jesus M F | 2002 | Journal of Food Engineering2002，54，4： | 1 |
| 4 | 显示文摘 | Water F A J Fernanda C F Canduri | 2002 | Biochem Biophys Res Commun2002，293，： | 1 |
| 5 | Method of quantifying the loss of acidification activity of lactic acid starters during freezing and frozen storage 显示文摘 | FERNANDA F BEAL C CORRIEU G | 2000 | Dairy Research2000，67，： | 1 |
| 6 | Freezing protocol effect on quality properties of fruit tissue according to the fruit,the variety and the stage of maturity 显示文摘 | Sophie C B Fernanda F Morgane C | 2010 | LWT - Food Science and Technology2010，43，： | 1 |
| 7 | Method of quantifying the loss of acidification activity of lactic acid starters during freezing and frozen storage显示文摘 | | 2000 | Dairy Research2000，67，： | 1 |
| 8 | Kinetic modeling of coupled redox enzymatic systems for in situ regeneration of NADPH显示文摘 | Fernanda M B Tania K F Georgia DC M | 2002 | J Mol Catal B :Enzymatic2002，1920，： | 1 |
| 9 | Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi显示文摘 | Ana Carolina Alves de Paula e Silva Caroline Barcelos Costa-Orlandi Fernanda Patrícia Gullo Fernanda Sangalli-Leite Haroldo Cesar de Oliveira Julhiany de Fátima da Silva Liliana Scorzoni Nayla de Souza Pitangui Suélen Andrea Rossi Tatiane Benaducci Vaness | 2014 | Evidence-Based Complementary and Alternative Medicine2014，，： | 1 |
| 10 | Operating Conditions that Affect the Resistance of Lactic Acid Bacteria to Freezing and Frozen Storage显示文摘 | FERNANDA F CATHERINE B GEORGES C | 2001 | Cryobiology2001，43，： | 1 |
| 11 | Modelling 02 and CO2 Exchange for Development of Perforation-medi- ated Atmosphere Packaging显示文摘 | SUSANA C F FERNANDA A R ISABEL B M | 2000 | Journal of Food Engineer- ing2000，43，： | 1 |
| 12 | Modelling respiration rate of shredded Galega kale for development of modified atmosphere packaging 显示文摘 | Susana C F Fernanda A R O Jesus M F | 2002 | Journal of Food Engineering2002，54，4： | 1 |
| 13 | Extending shelf life of shredded Galega kale using a modified atmosphere package显示文摘 | Susana C F Fernanda A R O Jesus M F | 2004 | Electronic Journal of Environmental Agricultural and Food Chemistry2004，3，5： | 1 |
| 14 | Molecular model of cyclin-dependent kinase S complexed with roscovitine显示文摘 | Walter F A Renato T G Fernanda C | 2002 | Biochem Biophys Res Commun2002，297，5： | 1 |
| 15 | Lipophilic phenolic antioxidants: Correlation between antioxidant profile, partition coefficients and redox properties显示文摘 | Fernanda M.F. Roleira Christophe Siquet Elizabeta Orrù E. Manuela Garrido Jorge Garrido Nuno Milhazes Gianni Podda Fátima Paiva-Martins Salette Reis Rui A. Carvalho Elisiário J. Tavares da Silva Fernanda Borges | 2010 | Bioorganic & Medicinal Chemistry2010，，16： | 1 |
| 16 | Living kidney donors – a prospective study of quality of life before and after kidney donation显示文摘 | Márcia Fátima Faraldo Martinez Garcia Luis Gustavo M. Andrade Maria Fernanda C. Carvalho | 2012 | Clin Transplant2012，，1： | 1 |
| 17 | Polymorphism analysis in genes of the somatotropic axis in Nellore cattle selected for growth显示文摘 | Diercles Francisco Cardoso Fábio Ricardo Pablos de Souza Gregório Miguel Ferreira de Camargo Patrícia Dias da Silva Fonseca Larissa Fernanda Simielli Fonseca Camila Urbano Braz Arione Augusti Boligon Maria Eugênia Zerlotti Mercadante Lucia Galv?o de Albuq | 2014 | Gene2014，，2： | 1 |
| 18 | Mycophenolate mofetil treatment in two children with severe polyarteritis nodosa refractory to immunosuppressant drugs显示文摘 | Fernanda F Serena C Giustina R | 2012 | Rheumatol Int2012，32，7： | 1 |
| 19 | Functional fermented whey-based beverage using lactic acid bacteria显示文摘 | Micaela Pescuma Elvira Mar f a H 6 bert Fernanda Mozzi | 2010 | International Journal of Food Microbiology2010，，141： | 1 |
| 20 | Traditional Uses, Chemical Constituents, and Biological Activities of Bixa orellana L.: A Review显示文摘 | Daniela de Araújo Vilar Marina Suênia de Araujo Vilar Túlio Flávio Accioly de Lima e Moura Fernanda Nervo Raffin Márcia Rosa de Oliveira Camilo Flamarion de Oliveira Franco Petr?nio Filgueiras de Athayde-Filho Margareth de Fátima Formiga Melo Diniz José M | 2014 | The Scientific World Journal2014，，： | 1 |
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