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| 1 | Dyspepsia and Irritable Bowel Syndrome After a Salmonella Gastroenteritis Outbreak: One-Year Follow-up Cohort Study显示文摘 | Fermín Mearin Marc Pérez-Oliveras Antonia Perelló Jaume Vinyet Anabel Iba?ez Jordi Coderch Mónica Perona | 2005 | Gastroenterology2005，，1： | 2 |
| 2 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 3 | Depositional control of mineable coal bodies显示文摘 | | 1984 | Spe Publs Lnt Ass Sediment1984，，7： | 1 |
| 4 | Depositional models in coal exploration and miner planing in Appalachian region 显示文摘 | Horne J C Ferm J C Baganz B P | 1976 | AAPG Bulle- tin1976，62，12： | 1 |
| 5 | ,Methane oxidation in soil profiles of Dutch and Finnish coniferous forests with different soil texture and atmospheric nitrogen deposition显示文摘 | MARTIKAINEN P J FERM A | 1997 | Soil Biol Biochem1997，29，： | 1 |
| 6 | Depositional models in coal exploration and miner planning in Appalachian region 显示文摘 | HORNE J C FERM J C BAGANZ B P | 1976 | AAPG Bulletin1976，62，12： | 1 |
| 7 | Cost-efficient techniques for urban- and background measurements of SO2 and NO2 显示文摘 | Ferm M Svanberg P A | 1998 | Atmospheric Environment1998，32，8： | 1 |
| 8 | Depositional models in coal exploration and mine planning in Appalachian region显示文摘 | HORNE J C FERM J C BAGANZ B P | 1978 | AAPG1978，62，12： | 1 |
| 9 | Association of IL10 promoter polymorphisms with idiopathic achalasia显示文摘 | Concepción Nu?ez María Asunción García-González Jose Luis Santiago María Soledad Benito Fermín Mearín Emilio G. de la Concha Julio Pérez de la Serna Antonio Ruiz de León Elena Urcelay Ana G. Vigo | 2011 | Human Immunology2011，，9： | 1 |
| 10 | Prognosis of patients with advanced Hodgkin' s disease: evaluation of four prognostic models using 344 patients included in the Group d' Etudes des Lymphomes de 1' Adulte Study显示文摘 | FERME C BASTION Y BRICE P | 1997 | Cancer1997，80，6： | 1 |
| 11 | Unusual, promo- ted release of guests from amphiphilic cross-linked polymer networks 显示文摘 | Brown G O Bergquist C Ferm P | 2005 | Journal of the American Chemical Society2005，127，11： | 1 |
| 12 | Depositional models in coal exploration and miner planing in Appalachian region 显示文摘 | Horne J C Ferm J C Baganz B P | 1976 | AAPG Buifetin1976，62，12： | 1 |
| 13 | Association of IL10 promoter polymorphisms with idiopathic achalasia显示文摘 | Concepción Nu?ez María Asunción García-González Jose Luis Santiago María Soledad Benito Fermín Mearín Emilio G. de la Concha Julio Pérez de la Serna Antonio Ruiz de León Elena Urcelay Ana G. Vigo | 2011 | Human Immunology2011，，9： | 1 |
| 14 | Methane oxidation insoil profiles of Dutch and Finnish coniferous forests with differenttexture and atmospheric nitrogen deposition显示文摘 | SAARI A MARTIKAINEN P J FERM A | 1997 | Soil Biology and Bio-chemistry1997，29，： | 1 |
| 15 | Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytes in vitro andin vivo显示文摘 | RENSEN P C N SLIEDREGT L A J M FERMS M | 2001 | J Biol Chem2001，276，37： | 1 |
| 16 | Risk-adapted salvage treatment with single or tandem autologous stem-cell transplanta- tion for first relapse/refractory Hodgkin's lymphoma: results of the prospective multicenter H96 trial by the GELA/SFGM study group 显示文摘 | Morschhauser F Brice P Ferme C | 2008 | J Clin Oncol2008，26，36： | 1 |
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