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| 1 | Early-onset colorectal cancer:A separate subset of colorectal cancer显示文摘Colorectal cancer(CRC)has a great impact on the world population.With increasing frequency,CRC is described according to the presenting phenotype,based on its molecular characteristics.Classification of CRC tumors according to their genetic and/or epigenetic alterations is not only important for establishing the molecular bases of the disease,but also for predicting patient outcomes and developing more individualized treatments.Early-onset CRC is a heterogeneous disease,with a strong familial component,although the disease is sporadic in an important proportion of cases.Different molecular alterations appear to contribute to the apparent heterogeneity of the early-onset population and subgroups can be distinguished with distinct histopathologic and familial characteristics.Moreover,compared with late-onset CRC,there are characteristicsthat suggest that early-onset CRC may have a different molecular basis.The purpose of this review was to analyze the current state of knowledge about earlyonset CRC with respect to clinicopathologic,familial and molecular features.Together,these features make it increasingly clear that this subset of CRC may be a separate disease,although it has much in common with late-onset CRC. | Irene Osorio Silla Daniel Rueda Yolanda Rodríguez Juan Luis García Felipe de la Cruz Vigo José Perea | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
| 2 | Microstructure of fabrics chemically finished for thermal adaptability 显示文摘 | Goynes W R Vigo T L Bruno J S | 1990 | Textile Res J1990，60，5： | 1 |
| 3 | Thermal properties of insolubilized poly- acetals derived from non-formaldehyde crosslinking agents显示文摘 | Bruno J S Vigo T L | 1994 | Thermochim Acta1994，243，2： | 1 |
| 4 | The two-echelon capacitated vehicle routing problem: Models and math-based heuristics显示文摘 | Perboli G Tadei R Vigo D | 2011 | Transportation Science2011，45，3： | 1 |
| 5 | Heuristic algorithms for the three-dimensional bin packing problem显示文摘 | Andrea Lodi Silvano martello Daniele Vigo | 2002 | European Journal of Operational Research2002，141，： | 1 |
| 6 | A heuristic algorithm for the symmetric and asymmetric vehicle routing problem with backhauls显示文摘 | Toth P Vigo D | 1999 | European Journal of Operational Research 1131999，，： | 1 |
| 7 | Wavelet transform shows age-related changes of heart rate variability within independent frequency components 显示文摘 | Vigo D E Ouinjoan S M Scaramal M | 2005 | Autonomic Neuroscience2005，123，2： | 1 |
| 8 | An exact algorithm for the vehicle routing problem with backhauls显示文摘 | Toth P Vigo D | 1997 | Transportation Science1997，31，： | 1 |
| 9 | Bio-control of the pathogen Phytophthoraparasitica by arbuscular mycorrhizalfungi is a consequence of effects on in-fection loci显示文摘 | Vigo C Norman J I L Hooker J E | 2000 | Plant Pathol2000，49，4： | 1 |
| 10 | Ultrafiltration membranes obtained by graftinghydrophilic monomers onto poly(vinyl chloride)显示文摘 | Vigo F Uliana C | 1989 | Journal ofApplied Polymer Science1989，38，7： | 1 |
| 11 | Pregnancy diagnosis in dairy cows by whey progesterone analysis: an ROC approach显示文摘 | FAUSTINI M BATTOCCHIO M VIGO D | 2007 | Theriogenology2007，67，8： | 1 |
| 12 | Heuristic algorithms for the handicapped persons transportation problem显示文摘 | Toth P Vigo D | 1997 | Transportation Science1997，31，1： | 1 |
| 13 | Evaluation of the prophy- lactie use of mitomycin-C to inhibit haze formation after photore- fractive keralectomy 显示文摘 | Carones F Vigo L Scandola E | 2002 | Cataract Refraet Surg2002，28，： | 1 |
| 14 | Approximation algorithms for the oriented two-dimensional bin packing problem 显示文摘 | LODI A MARTELLO S VIGO D | 1999 | European Journal of Operational Research1999，112，1： | 1 |
| 15 | Heuristics for the traveling salesman problem with pickup and delivery显示文摘 | Michel Gendreau Gilbert Laporte Daniele Vigo | | 0，，： | 1 |
| 16 | A heuristic algorithm for the symmetric and asymmetric vehicle routing problems with backhauls显示文摘 | TOTH P VIGO D | 1999 | European Journal of Operational Research1999，113，3： | 1 |
| 17 | Oxidation of selectedorganophosphate pesticides during chlorination of simulateddrinking water显示文摘 | Kamel A Byrne C Vigo C | 2009 | Water Research2009，43，2： | 1 |
| 18 | Elevation of microtubule-associated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease显示文摘 | Vigo Pelfrey C Seubert P Barbour R | 1995 | Neurology1995，45，： | 1 |
| 19 | Fat injection for cases ofsevere burn outcomes:a new perspective of scar remodeling andreduction显示文摘 | Klinger M Marazzi M Vigo D | 2008 | Aesthetic Plast Surg2008，32，： | 1 |
| 20 | Temperature-adaptable textiles containing durably bound polyethylene glycols显示文摘 | Bruno J S Vigo T L | 1987 | Textile Res J1987，57，7： | 1 |
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