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| 1 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 2 | Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice(ob/ob)显示文摘AIM:To investigate the colocalization,density and profile of neuronal areas of enteric neurons in the ileum of male obese mice.METHODS:The small intestinal samples of male mice in an obese group(OG)(C57BL/6J ob/ob)and a control group(CG)(+/+)were used.The tissues were analyzed using a double immunostaining technique for immunoreactivity(ir)of the P2X2 receptor,nitric oxide synthase(NOS),choline acetyl transferase(ChAT)and calretinin(Calr).Also,we investigated the density and profile of neuronal areas of the NOS-,ChAT-and Calrir neurons in the myenteric plexus.Myenteric neurons were labeled using an NADH-diaphorase histochemical staining method.RESULTS:The analysis demonstrated that the P2X2receptor was expressed in the cytoplasm and in the nuclear and cytoplasmic membranes only in the CG.Neuronal density values(neuron/cm2)decreased 31%(CG:6579±837;OG:4556±407)and 16.5%(CG:7796±528;OG:6513±610)in the NOS-ir and calretininir neurons in the OG,respectively(P<0.05).Density of ChAT-ir(CG:6200±310;OG:8125±749)neurons significantly increased 31%in the OG(P<0.05).Neuron size studies demonstrated that NOS,ChAT,and Calr-ir neurons did not differ significantly between the CG and OG groups.The examination of NADH-diaphorase-positive myenteric neurons revealed an overall similarity between the OG and CG.CONCLUSION:Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir,ChAT-ir and CalR-ir myenteric neurons. | Márcia Sanae Mizuno Amanda Rabello Crisma Primavera Borelli Bárbara Tavares Schfer Mariana Póvoa Silveira Patricia Castelucci | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 3 | Nerve Growth Factor and Artemin Are Paracrine Mediators of Pancreatic Neuropathy in Pancreatic Adenocarcinoma显示文摘 | Güralp O. Ceyhan Karl-Herbert Sch?fer Annika G. Kerscher Ulrich Rauch Ihsan Ekin Demir Mustafa Kadihasanoglu Carolin B?hm Michael W. Müller Markus W. Büchler Nathalia A. Giese Mert Erkan Helmut Friess | 2010 | Annals of Surgery2010，，5： | 2 |
| 4 | Neural invasion in pancreatic cancer: A mutual tropism between neurons and cancer cells显示文摘 | Güralp O. Ceyhan Ihsan Ekin Demir Burak Altintas Ulrich Rauch Gerald Thiel Michael W. Müller Nathalia A. Giese Helmut Friess Karl-Herbert Sch?fer | 2008 | Biochemical and Biophysical Research Communications2008，，3： | 2 |
| 5 | A Short Amino-Terminal Part of Arabidopsis Phytochrome A Induces Constitutive Photomorphogenic Response显示文摘Phytochrome A (phyA ) 是在 Arabidopsis thaliana 察觉到的 far-red 光的主导的光敏电阻器。phyA 在发信号的变白的幼苗,和导致光的 phyA 的细胞质在高水平积累被一个复杂规章的网络调停。这包括光 -- 并且进在 vivo 的原子核的本国的 phyA 的 FHY1/FHL 蛋白质依赖者 translocation。phyA (PHYA406 ) 的短 N 终端碎片对 phenocopy 足够,这也被显示出在 vitro 的这个高度调整的细胞的过程。为了测试这 N 终端的生物活动,在 planta phyA 碎裂,我们生产了表示 PHYA406YFP 的转基因的 phyA-201 植物(黄荧光灯蛋白质) DD, PHYA406YFPDDNLS (原子本地化信号) ,和 PHYA406YFPDDNES (原子出口信号) 熔化蛋白质。这里,我们报导 PHYA406YFPDD 被进口进原子核,而 PHYA406YFPDDNLS 和 PHYA406YFPDDNES 显示期望的组成的本地化模式,这进程部分是轻依赖者的。我们的结果证明这些截断的 phyA 蛋白质是轻马厩的,当局部性时,他们在他们的原子核,和两个都不触发组成的象 photomorphogenic 一样回答导致合适的 phyA 发信号。我们证明在 vitro 并且在 vivo PHYA406, Pfr 和 Pr 绑 COP1, photomorphogenesis 的一个一般抑压者,并且在原子身体与它共同本地化。因此,我们断定在 planta,截断的 PHYA406 蛋白质以一种光无关的方式在原子核使 COP1 失去活性。 | Andra's Viczia'n E'va Ada'm Iris Wolf Ja'nos Bindics Stefan Kircher Marc Heijde Roman Ulm Eberhard Scha'fer Ferenc Nagy | 2012 | Molecular Plant2012，5，3： | 2 |
| 6 | Laparoscopic versus open splenectomy for nontraumatic diseases显示文摘 | Maurus CF Sch(a)fer M Müller MK | | 0，，： | 1 |
| 7 | Behavioral and Physiological responses of young horses to different weaning Protocols:a Pilot study显示文摘 | Erber R Wulf M Rose-Meierh fer S | 2012 | Stress2012，15，2： | 1 |
| 8 | Extracellular laccase in ascomycetes Trichoderma atroviride and Trichoderma harzianum显示文摘 | H(o)lker U Dohse J H(o)fer M | 2002 | Folia Microbiologica2002，47，2： | 1 |
| 9 | Cloning,sequencing,and characterization of a heat-and alkali-stable type Ⅰ pullulanase from Anaerobranca gottschalkii显示文摘 | Bertoldo C Armbrecht M Becker F Sch(a)fer T Antranikian G Liebl W | | 0，，06： | 1 |
| 10 | Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine 显示文摘 | Becker J Sch?fer R Kohlstedt M | 2013 | Microbial Cell Factories2013，12，1： | 1 |
| 11 | The Netherlands:Health system review显示文摘 | Sch fer W Kroneman M Boerma W van den Berg M Westert G Devill é W and van Ginneken E | | 0，，01： | 1 |
| 12 | Continuous adrninistra?tion of sorafenib in combination with transarterial che?moembolization in patients with hepatocellular carcino?ma s results of a phase I study显示文摘 | DufourJ Fv Hoppe H Heim M H Helbling B Mau?rho fer 0 Szucs- Farkas Z | 2010 | Oncoiogist2010，15，11： | 1 |
| 13 | Somatosensory evoked potential phase reversal and direct motor cortex stimula- tion during surgery in and around the central region显示文摘 | CEDZICH C TANIQUCHI M SCH?FER S | 1996 | Neuro- surgery1996，38，5： | 1 |
| 14 | Physical and microstructuralproperties of biodegradable films based on pea starch and PVA显示文摘 | Cano A I Cháfer M Chiralt A | 2015 | Journal of Food Engineering2015，167，12： | 1 |
| 15 | The hydra phenomenon of cancer:why tumors recur locally after microscopically complete resection显示文摘 | HOCKEL M DORNHFER N | 2005 | Cancer Res2005，65，8： | 1 |
| 16 | Matrixmetalloproteinases as imaging targets for inflammatory activity in atherosclerotic plaques 显示文摘 | Sch fers M Schober O Hermann S | 2010 | J Nucl Med2010，51，5： | 1 |
| 17 | Enhanced glucose tolerance by SK4channel inhibition in pancreatic beta-cells显示文摘 | DFER M GIER B WOLPERS D | 2009 | Diabetes2009，58，8： | 1 |
| 18 | Peripheral analgesic and anti nflammatory effects of opioids显示文摘 | Stein C Machelska H Sch?fer M | | 0，，06： | 1 |
| 19 | Is the internet a better public sphere? Comparing old and new media in the USA and Germany显示文摘 | Gerhards J Sch fer M S | | 0，，01： | 1 |
| 20 | Vascular ul- trasound for the pre-operative evaluation prior to ar teriovenous fistula formation for haemodialysis: re- view of the evidence显示文摘 | Ferring M Henderson J Wilmink A | 2008 | Nephrol Dial Transplant2008，23，6： | 1 |
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