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| 1 | Improving uniform scattering device for straw-smashing,back-throwing,no-tillage planter under complete straw mulching condition显示文摘With the objective of obtaining a completely straw-mulched field,when no-tillage mechanical sowing is implemented with straw smashing,delivering,and back-throwing approaches,it may be difficult to scatter the smashed straw uniformly during a succeeding wheat sowing step.This is because the previous rice straw is substantial in quantity and has a high humidity and toughness,which may easily result in non-uniform straw mulching and thus sparse and weak seedlings of wheat.Therefore a force-dispersing and uniform-scattering device was designed.With the number of scattering impellers,impeller angle,and impeller rotation speed as the main factors and the percentage of pass for the scattering width and non-uniformity of the straw mulching as the assessment indices,single-factor experiments and orthogonal regressive tests were performed,and a dual-index(percentage of pass for the scattering width and non-uniformity of the straw mulching)fitted regression equation was established.The test results suggested that the main factors(from primary to secondary)that influence the indices were the impeller rotation speed,number of scattering impellers,and impeller angle.The optimal parameter combination for the uniform scattering device was four rows of impellers with an angle of 15°,rotation speed of 1015 r/min,percentage of pass of 72.65%for the scattering width,and a non-uniformity of 13.8%in the straw mulching.This combination can be used to realize a uniform scattering of the smashed straw along the seedling rows on the after-sowing ground.According to the field investigation of the wheat growth,the wheat emergence rate was 90.7%.The research results can provide a reference for improving the uniform scattering device for a straw-smashing,back-throwing,no-tillage planter for obtaining a completely straw-mulched field,enhancing the quality of the machinery operation,and ensuring good and strong seedlings after sowing. | Fengwei Gu Xuemei Gao Feng Wu Zhichao Hu Youqing Chen Chong Zhang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 5 |
| 2 | A novel superconducting magnetic levitation method to support the laser fusion capsule by using permanent magnets显示文摘A novel magnetic levitation support method is proposed, which can relieve the perturbation caused by traditional support methods andprovide more accurate position control of the capsule. This method can keep the perfect symmetry of the octahedral spherical hohlraum and hasthe characteristics in stability, tunability and simplicity. It is also favorable that all the results, such as supporting forces acting on the super-conducting capsule, are calculated analytically, and numerical simulations are performed to verify these results. A typical realistic design isproposed and discussed in detail. The superconducting coating material is suggested, and the required superconducting properties are listed.Damped oscillation of the floating capsule in thin helium gas is discussed, and the restoring time is estimated. | Xiaojia Li Tingting Xiao Fengwei Chen Yingjuan Zhang Xiaofei Li Weidong Wu | 2018 | Matter and Radiation at Extremes2018，3，3： | 4 |
| 3 | Sex disparity of lung cancer risk in non-smokers:a multicenter population-based prospective study based on China National Lung Cancer Screening Program显示文摘Background: Non-smokers account for a large proportion of lung cancer patients, especially in Asia, but the attention paid to them is limited compared with smokers. In non-smokers, males display a risk for lung cancer incidence distinct from the females-even after excluding the influence of smoking;but the knowledge regarding the factors causing the difference is sparse. Based on a large multicenter prospective cancer screening cohort in China, we aimed to elucidate the interpretable sex differences caused by known factors and provide clues for primary and secondary prevention.Methods: Risk factors including demographic characteristics, lifestyle factors, family history of cancer, and baseline comorbidity were obtained from 796,283 Chinese non-smoking participants by the baseline risk assessment completed in 2013 to 2018. Cox regression analysis was performed to assess the sex difference in the risk of lung cancer, and the hazard ratios (HRs) that were adjusted for different known factors were calculated and compared to determine the proportion of excess risk and to explain the existing risk factors.Results: With a median follow-up of 4.80 years, 3351 subjects who were diagnosed with lung cancer were selected in the analysis. The lung cancer risk of males was significantly higher than that of females;the HRs in all male non-smokers were 1.29 (95% confidence interval [CI]: 1.20-1.38) after adjusting for the age and 1.38 (95% CI: 1.28-1.50) after adjusting for all factors, which suggested that known factors could not explain the sex difference in the risk of lung cancer in non-smokers. Known factors were 7% (|1.29-1.38|/1.29) more harmful in women than in men. For adenocarcinoma, women showed excess risk higher than men, contrary to squamous cell carcinoma;after adjusting for all factors, 47% ([1.30-1.16]/[1.30-1]) and 4% ([7.02-6.75]/[7.02-1])) of the excess risk was explainable in adenocarcinoma and squamous cell carcinoma. The main causes of gender differences in lung cancer risk were lifestyle factors, baseline comorbidity, and family history.Conclusions: Significant gender differences in the risk of lung cancer were discovered in China non-smokers. Existing risk factors did not explain the excess lung cancer risk of all non-smoking men, and the internal causes for the excess risk still need to be explored;most known risk factors were more harmful to non-smoking women;further exploring the causes of the sex difference would help to improve the prevention and screening programs and protect the non-smoking males from lung cancers. | Zheng Wu Fengwei Tan Zhuoyu Yang Fei Wang Wei Cao Chao Qin Xuesi Dong Yadi Zheng Zilin Luo Liang Zhao Yiwen Yu Yongjie Xu Jiansong Ren Jufang Shi Hongda Chen Jiang Li Wei Tang Sipeng Shen Ning Wu Wanqing Chen Ni Li Jie He | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 4 | Lactobacillus plantarum CCFM8610 Alleviates Irritable Bowel Syndrome and Prevents Gut Microbiota Dysbiosis:A Randomized,Double-Blind,Placebo-Controlled,Pilot Clinical Trial显示文摘Irritable bowel syndrome with diarrhea(IBS-D)is chronic intestinal dysfunction with diarrhea and othercomplicated clinical symptoms,and it has a great impact on the daily life and mental state of patients.Some studies have reported that ingestion of probiotics can significantly alleviate a variety of intestinaldiseases.The pupose of this study was to investigate the IBS-D-alleviating effects of a probiotic strain,lactobacillus plantarum(L.plantarum)CCFM8610,with multiple health-promoting effects.The studywas a 12-week,randomized,double-blind,placebo-controlled,pilot clinical trial.Seventy-five patientswere randomly assigned to receive the placebo,oligosaccharides,or L.plantarum CCFM8610(1×10^(10) colony-forming units(CFU)per day),with a 2-week run-in period,an 8-week intervention period,anda 2-week follow-up observation period.The patients'clinical symptoms and quality of life were exam-ined by the IBS symptom severity scale(IBS-SsS)and the IlBS quality of life scale(IBS-QOL).Changes ingut microbiota composition and diversity were measured at the end of the intervention period.The oraladministration of L.plantarum CCFM8610 significantly decreased the IBS-SSS and IBS-QOL scores,reduced IBS-D symptom severity,recovered gut microbiota diversity,decreased the relative abundanceof bloating-related genus Methanobrevibacter,and increased the relative abundance of butyric acid-producing genera,including Anaerostipes,Anaerotruncus,Bifidobacterium,Butyricimonas,andOdoribacter.These findings suggest that ingestion of L.plantarum CCFM8610 can significantly alleviate clinical symptoms and gut microbiota dysbiosis in IBS-D patients.The IBS-D-alleviating effect of L.plan-tarum CCFM8610 may be related to theincrease in the relative abundance of butyric acid-producing genera in the intestine. | Yang Liu Xinjie Yu Leilei Yu Fengwei Tian Jianxin Zhao Hao Zhang Long Qian Qun Wang Zhengqing Xue Qixiao Zhai Wei Chen | 2021 | Engineering2021，7，3： | 2 |
| 5 | The Class Ⅲ peroxidase gene OsPrx30,transcriptionally modulated by the AT-hook protein OsATH1, mediates rice bacterial blight-induced ROS accumulation显示文摘Class Ⅲ peroxidases(CⅢ Prxs) play critical roles in plant immunity by scavenging reactive oxygen species(ROS). However, the functions of CⅢ Prxs in rice(Oryza sativa L.) immunity are largely unexplored. Here, we report a Prx precursor, OsPrx30,that is responsive to the bacterial blight Xanthomonas oryzae pv. oryzae(Xoo). OsPrx30 was primarily expressed in rice roots, leaves, and stems,and its protein product was mainly localized at the endoplasmic reticulum. Overexpression of OsPrx30 enhanced the plant’s susceptibility to Xoo by maintaining a high level of peroxidase(POD) activity and reducing the content of H2O2, whereas depletion of OsPrx30 had the opposite effects. Furthermore, we identified an AT-hook transcription factor, Os ATH1, that is specifically bound to the OsPrx30 promoter. As observed in plants overexpressing OsPrx30, depletion of Os ATH1 enhanced susceptibility to Xoo. Finally, we demonstrated that depletion of Os ATH1 increased histone H3 acetylation at the AT-rich region of the OsPrx30 promoter.Taken together, these results reveal a mechanism underlying the POD-induced natural resistance to bacterial diseases and suggest a model for transcription regulation of Prx genes in rice. | Hao Liu Shuangyu Dong Ming Li Fengwei Gu Guili Yang Tao Guo Zhiqiang Chen Jiafeng Wang | 2021 | Journal of Integrative Plant Biology2021，63，2： | 2 |
| 6 | MicroRNA-25 promotes cell migration and invasion in esophageal squamous cell carcinoma显示文摘 | Xiaohui Xu Zhaoli Chen Xiaohong Zhao Jiwen Wang Dapeng Ding Zhen Wang Fengwei Tan Xiaogang Tan Fang Zhou Jian Sun Nan Sun Yibo Gao Kang Shao Ning Li Bin Qiu Jie He | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 2 |
| 7 | Orthogonal projection based subspace identification against colored noise显示文摘在这份报纸,一个消除偏爱的 subspace 鉴定方法为易于的工业应用被建议给噪音涂颜色。基于两倍直角的设计,一个鉴定算法被开发为植物的扩大 observability 矩阵的一致评价消除有颜色的噪音的影响州空间的模型。一条移动不变的途径然后被给从估计的扩大 observability 矩阵检索系统矩阵。为扩大 observability 矩阵的一致评价的坚持的刺激条件被分析。而且,一个数字算法被给计算估计的扩大 observability 矩阵的评价错误。二个解说性的例子被给表明建议方法的有效性和优点。 | Jie HOU Tao LIU Fengwei CHEN | 2017 | Control Theory and Technology2017，15，1： | 1 |
| 8 | Screening of lactobacilli with antagonistic activity against enteroinvasive Escherichia coli显示文摘 | Xiaoming Liu Wenyu Liu Qiuxiang Zhang Fengwei Tian Gang Wang Hao Zhang Wei Chen | 2013 | Food Control2013，，2： | 1 |
| 9 | Gelatinization of cornstarch with different amylose/amylopectin content显示文摘 | Hongsheng Liu Long Yu Fengwei Xie Ling Chen | 2006 | Carbohydrate Polymers2006，，3： | 1 |
| 10 | Navier-Stokes simulations for transport aircraft wing/body high-lift configurations 显示文摘 | HAIXIN CHEN SONG FU FENGWEI LI | 2003 | Journal of aircraft2003，40，10： | 1 |
| 11 | Capsular polysaccarides of probiotics and their immunomodulatory roles显示文摘Studies have determined the immunomodulatory activities of cell-surface polysaccharides of lactic acid bacteria(LAB)and Bacteroides;however,the mechanisms,synthesis,regulation,structure,and functional links have not been systematically discussed.We first introduce the structure of the capsular poly saccharides(CPS s)of commonly studied probiotics and Bacteroides.Wzx-Wzy dependent and ATP-binding cassette(ABC)transporter-dependent pathways are the two main biosynthesis and secretion of CPS pathways.The genes known to be associated with these two pathways are mainly those associated with priming glycosyltransferase(pGT);a variable number of genes encoding for different glycosyl transferases(GTs);Wzx/Wzy-encoding enzymes related to flippases and polymerases;and ABC-transporter genes.In addition,the effects of CPSs on host immunity as well as their related underlying mechanisms are described.Surface polysaccharides on probiotics can serve as a mask to aid in their escape from attacks from the host’s immune system.In turn,they also exhibit immunomodulatory activities,such as strengthening the functions of macrophages,promoting the maturation of antigen-presenting cells,and inducing regulatory T cells.All of these effects of cell-surface polysaccharides exhibit their significant protective properties in immunocompromised diseases,such as colitis,arthritis,and dermatitis.Finally,we focused on their structure and functional links. | Jing Li Saisai Feng Leilei Yu Jianxin Zhao Fengwei Tian Wei Chen Qixiao Zhai | 2022 | Food Science and Human Wellness2022，11，5： | 1 |
| 12 | Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 from Sebekia benihana显示文摘The cytochrome P450 enzyme CYP-sb21 from the rare actinomycete Sebekia benihana is capable of hydroxylating the immunosuppressive drug molecule cyclosporine A(CsA)primarily at the 4th N-methyl leucine(MeLeu4),giving rise toγ-hydroxy-N-methyl-L-Leu4-CsA(CsA-4-OH).This oxidative modification of CsA leads to dramatically reduced immunosuppressive activity while retaining the hair growth-promoting side-effect,thus demonstrating great application potential in both pharmaceutical and cosmetic industries.However,this P450 enzyme also hydroxylates CsA at the unwanted position of the 9th N-methyl leucine(MeLeu9),indicating that the regioselectivity needs to be improved for the development of CsA-4-OH into a commercial hair growth stimulator.Herein,we report the crystal structure of CYP-sb21 in its substrate-free form at 1.85Å.Together with sequence and 3D structure comparisons,Autodock-based substrate docking,molecular dynamics(MD)simulation,and site-directed mutagenesis,we identified a number of key residues including R294,E264,and M179 that can improve catalytic efficiency or change the regioselectivity of CYP-sb21 towards CsA,setting the stage for better enzymatic preparation of CsA-4-OH.This study also provides new insights into the substrate recognition and binding mechanism of P450 enzymes that accommodate bulky substrates. | Fengwei Li Li Ma Xingwang Zhang Jingfei Chen Feifei Qi Yinyue Huang Zepeng Qu Lishan Yao Wei Zhang Eung-Soo Kim Shengying Li | 2020 | Synthetic and Systems Biotechnology2020，5，3： | 1 |
| 13 | Effects of amylose and phosphate monoester on aggregation structures of heat-moisture treated potato starches显示文摘 | Binjia Zhang Yue Zhao Xiaoxi Li Panfeng Zhang Lin Li Fengwei Xie Ling Chen | 2013 | Carbohydrate Polymers2013，，： | 1 |
| 14 | Lactobacillus plantarum CCFM8661 Alleviates Lead Toxicity in Mice显示文摘 | Fengwei Tian Qixiao Zhai Jianxin Zhao Xiaoming Liu Gang Wang Hao Zhang Heping Zhang Wei Chen | 2012 | Biological Trace Element Research2012，，1： | 1 |
| 15 | Gelatinization of cornstarch with different amylose/amylopectin content显示文摘 | Hongsheng Liu Long Yu Fengwei Xie Ling Chen | 2006 | Carbohydrate Polymers2006，，3： | 1 |
| 16 | MicroRNA-99a/100 promotes apoptosis by targeting mTOR in human esophageal squamous cell carcinoma显示文摘 | Jian Sun Zhaoli Chen Xiaogang Tan Fang Zhou Fengwei Tan Yibo Gao Nan Sun Xiaohui Xu Kang Shao Jie He | 2013 | Medical Oncology2013，，1： | 1 |
| 17 | Assembly process and source tracking of microbial communities in sediments of Dongting Lake显示文摘●Soil erosion resulted in homogenization of bacterial communities in the watershed.●Microbial community heterogeneity among erosion sites made soil tracing possible.●Assembly process results showed that the tracking results can achieve high precision.●Dryland was the main source of sediment deposition based on the result of FEAST.Sediment source tracing can accurately provide a theoretical basis for controlling soil erosion effectively,by identifying the most serious types of land use.Traditional sediment tracing methods are based on physical,chemical,biological,and composite fingerprinting,which have not included microbes.As high-throughput sequencing becomes more prevalent,microorganisms can provide more information than what we think.Thus,whether the microorganism can also be used as a special fingerprint factor for sediment source identification during soil erosion,we have tested it by using microbial source tracking tool FEAST to quantify the microbe contribution from five types of eroded land(including dryland,urban,paddy field,forest and grassland)to the depositional areas(Niubitan)in the Yuanjiang basin.The source microbial community in the erosive area was heterogeneous,and assembly process analysis further demonstrated that the source tracking results could reach higher accuracy.The results of FEAST showed that dryland(35.50%),urban(17.21%),paddy field(8.14%),and forest(1.07%)were the major contributors to Niubitan.Our results follow the general soil erosion rules and prove its validity.Taken together,a new perspective is provided by these results for tracing sediment sources in erosion-sedimentary systems. | Wenfei Liao Di Tong Xiaodong Nie Yaojun Liu Fengwei Ran Shanshan Liao Jia Chen Aoqi Zeng Zhongwu Li | 2023 | Soil Ecology Letters2023，5，4： | 1 |
| 18 | Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma显示文摘Adenosine-to-inosine(A-to-I)RNA editing is a widespread posttranscriptional modification that has been shown to play an important role in tumorigenesis.Here,we evaluated a total of 19,316 RNA editing sites in the tissues of 80 lung adenocarcinoma(LUAD)patients from our Nanjing Lung Cancer Cohort(NJLCC)and 486 LUAD patients from the TCGA database.The global RNA editing level was significantly increased in tumor tissues and was highly heterogeneous across patients.The high RNA editing level in tumors was attributed to both RNA(ADAR1 expression)and DNA alterations(mutation load).Consensus clustering on RNA editing sites revealed a new molecular subtype(EC3)that was associated with the poorest prognosis of LUAD patients.Importantly,the new classification was independent of classic molecular subtypes based on gene expression or DNA methylation.We further proposed a simplified model including eight RNA editing sites to accurately distinguish the EC3 subtype in our patients.The model was further validated in the TCGA dataset and had an area under the curve(AUC)of the receiver operating characteristic curve of 0.93(95%CI:0.91-0.95).In addition,we found that LUAD cell lines with the EC3 subtype were sensitive to four chemotherapy drugs.These findings highlighted the importance of RNA editing events in the tumorigenesis of LUAD and provided insight into the application of RNA editing in the molecular subtyping and clinical treatment of cancer. | Cheng Wang Mingtao Huang Congcong Chen Yuancheng Li Na Qin Zijian Ma Jingyi Fan Linnan Gong Hui Zeng Liu Yang Xianfeng Xu Jun Zhou Juncheng Dai Guangfu Jin Zhibin Hu Hongxia Ma Fengwei Tan Hongbing Shen | 2022 | Science China(Life Sciences)2022，65，1： | 1 |
| 19 | Phospho- tungstic Acid Containing Ioin Liquid Immobilized on Magetic Mesoporous Silica Rod Catalyst for the Oxidation of Dibenzo- thiophene with H2O2 显示文摘 | Chen Yuanzhe Zhang Fengwei Fang Yiyun | 2013 | Catal Commun2013，38，5： | 1 |
| 20 | Fabrication of ultrathin Zn(OH)2 nanosheets as drug carriers显示文摘Ultrathin 二维(2D ) 多孔的 Zn (哦)2 nanosheets (PN ) 作为脊梁借助于一个维的 Cu nanowires 被制作。PN 有约 3.8 nm 的厚度和 4-10 nm 的毛孔尺寸。形成聪明的多孔的 nanosheets, DNA aptamers covalently 被结合到 PN 的表面。好 biocompatibility,有效细胞的举起,和有希望的刺激 pH 的药释放的这些 ultrathin nanosheets 表演。 | Ren Cai Dan Yang Jin Wu Liqin Zhang Cuichen Wu Xigao Chen Yanyue Wang Shuo Wan Fengwei HOU Qingyu Yan Weihong Tan | 2016 | Nano Research2016，9，8： | 1 |
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