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| 1 | Large-scale analysis of small RNAs derived from traditional Chinese herbs in human tissues显示文摘Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development. | Fengming Huang Jianchao Du Zhu Liang Zhichao Xu Jiantao Xu Yan Zhao Yexuan Lin Song Mei Quan He Jindong Zhu Qiang Liu Yanxu Zhang Yuhao Qin Wei Sun Jingyuan Song Shilin Chen Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 14 |
| 2 | The effect of Scuteilaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats显示文摘Flavonoids 被显示了改进认知功能并且推迟痴呆前进。然而,内在的机制留下逃犯。在现在的学习,我们检验了从 S 提取的黄芩 baicalensis 茎叶总数 flavonoids (SSTF ) 的效果。在脉管的痴呆(VaD ) 的空间学习和记忆上的 baicalensis Georgi 老鼠模型并且探索了它的分子的机制。VaD 老鼠被普通颈动脉动脉的永久双边的吸藏开发。在恢复以后的七天, VaD 老鼠与 SSTF 的 50 或 100 mg/kg 被对待 60 天。空间学习和记忆在莫利斯舞水迷宫(MWM ) 被评估测试。字形物 hyperphosphorylation 和相关蛋白质 kinases 或磷酸酶的层次被西方的污点分析检验。在 VaD 老鼠,在 100 mg/kg 的 SSTF 处理显著地在在 MWM 测试训练试用减少了逃跑潜伏。在探针试用, SSTF 治疗在目标象限增加了寻找的时间和旅行距离。SSTF 处理在 VaD 老鼠在外皮和马头鱼尾的怪兽禁止了字形物 phosphorylation。同时, SSTF 减少了肝糖 synthase kinase 的活动 3 并且 cyclin 依赖的 kinase 5 在 VaD 老鼠。相反, SSTF 处理在 VaD 老鼠增加了蛋白质磷酸酶 2A 子单元 B 的水平。SSTF 处理显著地在 VaD 老鼠改进了空间认知。我们的结果建议 SSTF 可以通过在击以后协调 kinases 和磷酸酶的活动减轻 tau-hyperphosphorylation-induced neurotoxicity。SSTF 可以为 VaD 被开发进有希望的新奇治疗学。 | Yanjing Cao Lizhen Liang Jian Xu Jiali Wu Yongxing Yan Ping Lin Qiang Chen Fengming Zheng Qin Wang Qian Ren Zengmei Gou Yifeng Du | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 10 |
| 3 | Tool Orientation Optimization and Path Planning for 5-Axis Machining显示文摘Tool path generation is a fundamental problem in 5-axis CNC machining, which consists of tool orientation planning and cutter-contact(CC) point planning. The planning strategy highly depends on the type of tool cutters. For ball-end cutters, the tool orientation and CC point location can be planned separately;while for flat end cutters, the two are highly dependent on each other. This paper generates a smooth tool path of workpiece surfaces for flat end mills from two stages: Computing smooth tool orientations on the surface without gouging and collisions and then designing the CC point path. By solving the tool posture optimization problem the authors achieve both the path smoothness and the machining efficiency. Experimental results are provided to show the effectiveness of the method. | YUAN Chunming MI Zhenpeng JIA Xiaohong LIN Fengming SHEN Liyong | 2021 | Journal of Systems Science & Complexity2021，34，1： | 3 |
| 4 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://gffzz4a3adbfa122d4a47hq5wx59bxk5v06fnf.ffgz.tsg.suse.edu.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 5 | Copeptin in the assessment of acute lung injury and cardiogenic pulmonary edema显示文摘 | Qionghua Lin Fengming Fu Haiquan Chen Biao Zhu | 2012 | Respiratory Medicine2012，，9： | 2 |
| 6 | Spatial and temporal evolution of landfast ice near Zhongshan Station, East Antarctica, over an annual cycle in 2011/2012显示文摘Annual observations of first-year ice(FYI) and second-year ice(SYI) near Zhongshan Station, East Antarctica,were conducted for the first time from December 2011 to December 2012. Melt ponds appeared from early December 2011. Landfast ice partly broke in late January, 2012 after a strong cyclone. Open water was refrozen to form new ice cover in mid-February, and then FYI and SYI co-existed in March with a growth rate of 0.8 cm/d for FYI and a melting rate of 2.7 cm/d for SYI. This difference was due to the oceanic heat flux and the thickness of ice,with weaker heat flux through thicker ice. From May onward, FYI and SYI showed a similar growth by 0.5 cm/d.Their maximum thickness reached 160.5 cm and 167.0 cm, respectively, in late October. Drillings showed variations of FYI thickness to be generally less than 1.0 cm, but variations were up to 33.0 cm for SYI in March,suggesting that the SYI bottom was particularly uneven. Snow distribution was strongly affected by wind and surface roughness, leading to large thickness differences in the different sites. Snow and ice thickness in Nella Fjord had a similar 'east thicker, west thinner' spatial distribution. Easterly prevailing wind and local topography led to this snow pattern. Superimposed ice induced by snow cover melting in summer thickened multi-year ice,causing it to be thicker than the snow-free SYI. The estimated monthly oceanic heat flux was ~30.0 W/m2 in March–May, reducing to ~10.0 W/m2 during July–October, and increasing to ~15.0 W/m2 in November. The seasonal change and mean value of 15.6 W/m2 was similar to the findings of previous research. The results can be used to further our understanding of landfast ice for climate change study and Chinese Antarctic Expedition services. | Jiechen Zhao Qinghua Yang Bin Cheng Matti Lepp?ranta Fengming Hui Surui Xie Meng Chen Yining Yu Zhongxiang Tian Ming Li Lin Zhang | 2019 | Acta Oceanologica Sinica2019，38，5： | 2 |
| 7 | Orally administered BZL-s RNA-20 oligonucleotide targeting TLR4 effectively ameliorates acute lung injury in mice显示文摘The global COVID-19 pandemic emerged at the end of December 2019.Acute respiratory distress syndrome(ARDS)and acute lung injury(ALI)are common lethal outcomes of bacterial lipopolysaccharide(LPS),avian influenza virus,and SARS-Co V-2.Toll-like receptor 4(TLR4)is a key target in the pathological pathway of ARDS and ALI.Previous studies have reported that herbal small RNAs(s RNAs)are a functional medical component.BZL-s RNA-20(Accession number:B59471456;Family ID:F2201.Q001979.B11)is a potent inhibitor of Toll-like receptor 4(TLR4)and pro-inflammatory cytokines.Furthermore,BZLs RNA-20 reduces intracellular levels of cytokines induced by lipoteichoic acid(LTA)and polyinosinic-polycytidylic acid(poly(I:C)).We found that BZL-s RNA-20 rescued the viability of cells infected with avian influenza H5N1,SARS-Co V-2,and several of its variants of concern(VOCs).Acute lung injury induced by LPS and SARS-Co V-2 in mice was significantly ameliorated by the oral medical decoctosome mimic(bencaosome;sphinganine(d22:0)+BZL-s RNA-20).Our findings suggest that BZLs RNA-20 could be a pan-anti-ARDS/ALI drug. | Dandan Zhao Yuhao Qin Jiaqi Liu Kegong Tang Shuaiyao Lu Zirui Liu Yexuan Lin Cong Zhang Fengming Huang Jiahui Chang Chang Li Mingyao Tian Yiming Ma Xiaoyun Li Congzhao Zhou Xiao Li Xiaozhong Peng Ningyi Jin Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 8 | Benefit analysis of multi-approach biomass energy utilization toward carbon neutrality显示文摘To reduce greenhouse gas(GHG)emissions,biomass has been increasingly developed as a renewable and clean alternative to fossil fuels because of its carbon-neutral characteristics.China has been investigating the rational development and use of bioenergy for developing its clean energy and achieving carbon neutrality.Substituting fossil fuels with multi-source and multi-approach utilized bioenergy and corresponding carbon reduction in China remain largely unexplored.Here,a comprehensive bioenergy accounting model with a multi-dimensional analysis was developed by combining spatial,life cycle,and multi-path analyses.Accordingly,the bioenergy production potential and GHG emission reduction for each distinct type of biomass feedstock through different conversion pathways were estimated.The sum of all available organic waste(21.55 EJ yr^(-1))and energy plants on marginal land(11.77 EJ yr^(-1))in China produced 23.30 EJ of bioenergy and reduced 2,535.32 Mt CO_(2)-eq emissions,accounting for 19.48%and 25.61%of China’s total energy production and carbon emissions in 2020,respectively.When focusing on the carbon emission mitigation potential of substituting bioenergy for conventional counterparts,bioelectricity was the most effective,and its potential was 4.45 and 8.58 times higher than that of gaseous and liquid fuel alternatives,respectively.In this study,life cycle emission reductions were maximized by a mix of bioenergy end uses based on biomass properties,with an optimal 78.56%bioenergy allocation from biodiesel,densified solid biofuel,biohydrogen,and biochar.The main regional bioenergy GHG mitigation focused on the Jiangsu,Sichuan,Guangxi,Henan,and Guangdong provinces,contributing to 31.32%of the total GHG mitigation potential.This study provides valuable guidance on exploiting untapped biomass resources in China to secure carbon neutrality by 2060. | Jiaoyue Wang Jingying Fu Zhitong Zhao Longfei Bing Fengming Xi Feng Wang Jiang Dong Shiyun Wang Gang Lin Yan Yin Qinqin Hu | 2023 | The Innovation2023，4，3： | 0 |
| 9 | Multiple-Channel Weight-Based CNN Fault Diagnosis Method显示文摘It is difficult to comprehensively extract device status information for CNNs under a single source high-frequency timing signal,and CNNs cannot effec-tively achieve precise identification and classification based on the importance of multichannel features.This article proposes a CNN fault diagnosis method based on multi-channel weight adaptation.This methodfirst normalizes different data sources as input as different channels of CNN,and uses the characteristics of convolutional networks to achieve the characteristics of different data sources.Fusion and extraction.Then,the SNET module is embedded into the CNN net-work,adapted to the weight of each channel,and the accuracy of classification is improved.Finally,through comparative experiments,this method can further improve the accuracy of fault recognition. | Peng Xu Xinyu Liu Junyu Lin Zhongyu Lu Fengming Li Husheng Gou | 2023 | 国际计算机前沿大会会议论文集2023，，1： | 0 |
| 10 | Tropical Timber Trade Flows in P.R. China显示文摘The historical transition of timber distribution pattern in China was presented firstly with main parts of timber flows in China,which included timber markets,timber transport system and regulations of timber transport.Based on the overview on tropical timber flows in China,the trade flows of tropical timber from production and imports of tropical timber to export of tropical timber products were analyzed by vivid illustrations.At the same time,problems in timber trade flows in China were analysed in the end. | HU Yanjie LIN Fengming SHI Kunshan | 2007 | Chinese Forestry Science and Technology2007，6，2： | 0 |
| 11 | Investigating the cellular functions of β-Glucosidases for synthesis of lignocellulose-degrading enzymes in Trichoderma reesei显示文摘β-glucosidases play an important role in the synthesis of cellulase in fungi,but their molecular functions and mechanisms remain unknown.We found that the 10 putativeβ-glucosidases investigated in Trichoderma ree-sei facilitate cellulase production,with cel3j being the most crucial.Transcriptional analysis revealed that the most affected biological processes in△cel3j strain were cellulase synthesis,ribosome biogenesis,and RNA poly-merases.Moreover,CEL3J was unconventionally transported through the endoplasmic reticulum,bypassing the Golgi apparatus,whereas cel3j overexpression altered cellulase secretion from conventional to unconventional,likely owing to the activated unconventional protein secretion pathway(UPS),as indicated by the upregulation of genes related to UPS.The mTORC1-GRASP55 signaling axis may modulate the unconventional secretion of CEL3J and cellulase.The transcriptional levels of genes associated with DNA replication,the cell cycle,and meiosis were noticeably affected by overexpressing cel3j.These data give new clues for exploring the roles ofβ-glucosidases and the molecular mechanisms of their unconventional secretion in fungi. | Ai-Ping Pang Haiyan Wang Yongsheng Luo Funing Zhang Fu-Gen Wu Zhihua Zhou Zuhong Lu Fengming Lin | 2023 | Engineering Microbiology2023，3，4： | 0 |
| 12 | Dividing the transit wind speeds into intervals as a favorable methodology for analyzing the relationship between wind speed and the aerodynamic impedance of vegetation in semiarid grasslands显示文摘In grassland ecosystems,the aerodynamic roughness(Z0)and frictional wind speed(u*)contribute to the aerodynamic impedance of the grassland canopy.Thus,they are often used in the studies of wind erosion and evapotranspiration.However,the effect of wind speed and grazing measures on the aerodynamic impedance of the grassland canopy has received less analysis.In this study,we monitored wind speeds at multiple heights in grazed and grazing-prohibited grasslands for 1 month in 2021,determined the transit wind speed at 2.0 m height by comparing wind speed differences at the same height in both grasslands,and divided these transit wind speeds at intervals of 2.0 m/s to analyze the effect of the transit wind speed on the relationship among Z0,u*,and wind speed within the grassland canopy.The results showed that dividing the transit wind speeds into intervals has a positive effect on the logarithmic fit of the wind speed profile.After dividing the transit wind speeds into intervals,the wind speed at 0.1 m height(V0.1)gradually decreased with the increase of Z0,exhibiting three distinct stages:a sharp change zone,a steady change zone,and a flat zone;while the overall trend of u*increased first and then decreased with the increase of V0.1.Dividing the transit wind speeds into intervals improved the fitting relationship between Z0 and V0.1 and changed their fitting functions in grazed and grazing-prohibited grasslands.According to the computational fluid dynamic results,we found that the number of tall-stature plants has a more significant effect on windproof capacity than their height.The results of this study contribute to a better understanding of the relationship between wind speed and the aerodynamic impedance of vegetation in grassland environments. | LI Ruishen PEI Haifeng ZHANG Shengwei LI Fengming LIN Xi WANG Shuai YANG Lin | 2023 | Journal of Arid Land2023，15，8： | 0 |
| 13 | Potential oligonucleotide drugs in Bencao sRNA Atlas显示文摘Dear Editor,We read the Letter of Professor Shanfa Lu(Lu,2023)titled“Are herbal sRNAs really novel precision medicines?”In this Letter,Lu(2023)commented on our previously published manuscripts(Du et al.,2019;Huang et al.,2019)and concluded that“HJT-sRNA-m1–HJT-sRNA-m8,the eight sRNAs thought to be derived from R.crenulata,are actually derived from animal and/or human beings”. | Fengming Huang Jiaqi Liu Sifen Du Yexuan Lin Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，12： | 0 |
| 14 | Molecular imaging:design mechanism and bioapplications显示文摘Molecular imaging is a non-invasive method to image and analyze the concentration and activity of functional biomolecules in cells or in vivo at molecular level,and plays an increasing role in deep understanding of biological processes,early and accurate diagnosis of diseases,and evaluation of treatment.Nowadays,numerous novel molecular imaging probes have been developed,involving every biomedical imaging modality,such as optical imaging,photoacoustic imaging,magnetic resonance imaging,single-photon-emission computed tomography,and positron emission tomography.In this review,we summarize the development of current state-of-the-art molecular imaging probes.We introduce the design strategies of molecular probes and detailed imaging modalities,and highlight the properties of probes and biomedical imaging applications in cells and in vivo,including disease diagnosis,drug tracking,and imaging-guided surgery.Then we discuss the perspectives and challenges in this emerging field.We expect this review could inspire more effective molecular imaging probes to be developed,achieving the goal towards clinical practices. | Lanlan Chen Yifan Lyu Xuan Zhang Liting Zheng Qingqing Li Ding Ding Fengming Chen Yihao Liu Wei Li Yutong Zhang Qiuling Huang Zhiqiang Wang Tiantian Xie Qiang Zhang Yingyu Sima Ke Li Shuai Xu Tianbing Ren Mengyi Xiong Ying Wu Jibin Song Lin Yuan Huanghao Yang Xiao-Bing Zhang Weihong Tan | 2023 | Science China Chemistry2023，66，5： | 0 |
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