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| 1 | Risk factors and outcomes of acute kidney injury after intracoronary stent implantation显示文摘BACKGROUND:Acute kidney injury following percutaneous coronary intervention(PCI) is associated with a worse outcome.However,the risk factors and outcomes of acute kidney injury(AKI) in patients after intracoronary stent implantation are still unknown.METHODS:A retrospective case control study was done in 325 patients who underwent intracoronary stent implantation from January 2010 to March 2011 at the Drum Tower Hospital of Nanjing University School of Medicine.Those were excluded from the study if they had incomplete clinical data.The patients were divided into a normal group and a AKI group according to the standard of post-operation day 7 to identify AKI.The parameters of the patients included:1) pre-operative ones:age,gender,hypertension,diabetes mellitus,cerebrovascular disease,left ventricular insufficiency,peripheral angiopathy,creatinine,urea nitrogen,estimated glomerular filtration rate(eGFR),hyperuricemia,proteinuria,emergency operation,hydration,medications(ACEI/ARBs,statins);2) intraoperative ones:dose of contrast media,operative time,hypotension;and 3) postoperative one:hypotension.The parameters were analyzed with univariate analysis and multivariate logistical regression analysis.RESULTS:Of the 325 patients,51(15.7%) developed AKI.Hospital day and in-hospital mortality were increased significantly in the AKI-group.Univariate analysis showed that age,pre-operative parameters(left ventricular insufficiency,peripheral angiopathy,creatinine,urea nitrogen,estimated glomerular filtration rate,hyperuricemia,proteinuria,hydration),emergency operation,intraoperative parameters(operative time,hypotension) and postoperative hypotension were significantly different.However,multivariate logistic regression analysis revealed that increased age(OR=0.253,95%CI=0.088-0.727),pre-operative proteinuria(OR=5.351,95%CI=2.128-13.459),pre-operative left ventricular insufficiency(OR=8.704,95%CI=3.170-23.898),eGFR<60 ml/min/1.73 m^2(OR=6.677,95%CI = 1.167-38.193),prolonged operative time,intraoperative hypotension(OR=25.245,95%CI=1.001-1.034) were independent risk factors of AKI.CONCLUSIONS:AKI is a common complication and associated with ominous outcome following intracoronary stent implantation.Increased age,pre-operative proteinuria,pre-operative left ventricular insufficiency,pre-operative low estimated glomerular filtration rate,prolonged operative time,intraoperative hypotension were the significant risk factors of AKI. | Fei He Jun Zhang Zhong-qiu Lu Qing-ling Gao Du-juan Sha Li-gang Pei Guo-feng Fan | 2012 | World Journal of Emergency Medicine2012，3，3： | 11 |
| 2 | Active learning for accelerated design of layered materials显示文摘Hetero-structures made from vertically stacked monolayers of transition metal dichalcogenides hold great potential for optoelectronic and thermoelectric devices.Discovery of the optimal layered material for specific applications necessitates the estimation of key material properties,such as electronic band structure and thermal transport coefficients.However,screening of material properties via brute force ab initio calculations of the entire material structure space exceeds the limits of current computing resources.Moreover,the functional dependence of material properties on the structures is often complicated,making simplistic statistical procedures for prediction difficult to employ without large amounts of data collection.Here,we present a Gaussian process regression model,which predicts material properties of an input hetero-structure,as well as an active learning model based on Bayesian optimization,which can efficiently discover the optimal hetero-structure using a minimal number of ab initio calculations.The electronic band gap,conduction/valence band dispersions,and thermoelectric performance are used as representative material properties for prediction and optimization.The Materials Project platform is used for electronic structure computation,while the BoltzTraP code is used to compute thermoelectric properties.Bayesian optimization is shown to significantly reduce the computational cost of discovering the optimal structure when compared with finding an optimal structure by building a regression model to predict material properties.The models can be used for predictions with respect to any material property and our software,including data preparation code based on the Python Materials Genomics(PyMatGen)library as well as python-based machine learning code,is available open source. | Lindsay Bassman Pankaj Rajak Rajiv K.Kalia Aiichiro Nakano Fei Sha Jifeng Sun David J.Singh Muratahan Aykol Patrick Huck Kristin Persson Priya Vashishta | 2018 | npj Computational Materials2018，，1： | 10 |
| 3 | Purification and Characterization of a Low-temperature Hydroxylamine Oxidase from Heterotrophic Nitrifier Acinetobacter sp.Y16显示文摘Objective To purify a low-temperature hydroxylamine oxidase(HAO) from a heterotrophic nitrifying bacterium Acinetobacter sp.Y16 and investigate the enzyme property.Methods A HAO was purified by an anion-exchange and gel-filtration chromatography from strain Y16.The purity and molecular mass were determined by RP-HPLC and SDS-PAGE.The HAO activity was detected by monitoring the reduction of potassium ferricyanide using hydroxylamine as substrate and ferricyanide as electron acceptor.The partial amino acid sequence was determined by mass spectrometry.Results The low-temperature HAO with a molecular mass of 61 kDa was purified from strain Y16 by an anion-exchange and gel-filtration chromatography.The enzyme exhibited an ability to oxidize hydroxylamine in wide temperature range(4-40 ℃) in vitro using hydroxylamine as substrate and ferricyanide as electron acceptor.It was stable in the temperature range of 4 to 15 ℃ and pH range of6.0 to 8.5 with less than 30%change in its activity.The optimal temperature and pH were 15 ℃ and 7.5,respectively.Three peptides were determined by mass spectrometry which were shown to be not identical to other reported HAOs.Conclusion This is the first study to purify a low-temperature HAO from a heterotrophic nitrifier Acinetobacter sp.It differs from other reported HAOs in molecular mass and enzyme properties.The findings of the present study have suggested that the strain Y16 passes through a hydroxylamine-oxidizing process catalyzed by a low-temperature HAO for ammonium removal. | ZHANG Shu Mei LI Wei Guang ZHANG Duo Ying HUANG Xiao Fei QIN Wen SHA Chang Qing | 2014 | Biomedical and Environmental Sciences2014，27，7： | 6 |
| 4 | HSV-1 H129-Derived Anterograde Neural Circuit Tracers:Improvements, Production, and Applications显示文摘Anterograde viral tracers are powerful and essential tools for dissecting the output targets of a brain region of interest. They have been developed from herpes simplex virus 1(HSV-1) strain H129(H129), and have been successfully applied to map diverse neural circuits.Initially, the anterograde polysynaptic tracer H129-G4 was used by many groups. We then developed the first monosynaptic tracer, H129-dTK-tdT, which was highly successful, yet improvements are needed. Now, by inserting another tdTomato expression cassette into the H129-dTK-tdT genome, we have created H129-dTK-T2, an updated version of H129-dTK-tdT that has improved labeling intensity. To help scientists produce and apply our H129-derived viral tracers, here we provide the protocol describing our detailed and standardized procedures. Commonly-encountered technical problems and their solutions are also discussed in detail. Broadly, the dissemination of this protocol will greatly support scientists to apply these viral tracers on a large scale. | Hong Yang Feng Xiong Yi-Ge Song Hai-Fei Jiang Hai-Bin Qin Jing Zhou Sha Lu Steven FGrieco Xiangmin Xu Wen-Bo Zeng Fei Zhao Min-Hua Luo | 2021 | Neuroscience Bulletin2021，37，5： | 4 |
| 5 | Experimental investigation on active acoustic flutter control显示文摘Experimenial studies on active acoustic fiutter control are carried out successfully in wind-tunnel after the theoretical study The experdrients verify the theory presented in the reference[1] and give valuable experimeotal results which predict a prondsing future of applying new techology and new ideas to the area of vibration induced by flow. | YANG Jun(Institute of Acoustics, Academic Sinica Beijing 100080)(State Key Lab. of Modern Acoustics, Naniing Universitg Naning 210093)HAN Fei QIU Xiaojun and SHA Jiazheng(State Key Lab. of Modern Acoustics, Nanjing Universitg Naning 210093) | 1997 | Chinese Journal of Acoustics1997，16，1： | 3 |
| 6 | Big Earth data analytics:a survey显示文摘Big Earth data are produced from satellite observations,Internet-ofThings,model simulations,and other sources.The data embed unprecedented insights and spatiotemporal stamps of relevant Earth phenomena for improving our understanding,responding,and addressing challenges of Earth sciences and applications.In the past years,new technologies(such as cloud computing,big data and artificial intelligence)have gained momentum in addressing the challenges of using big Earth data for scientific studies and geospatial applications historically intractable.This paper reviews the big Earth data analytics from several aspects to capture the latest advancements in this fast-growing domain.We first introduce the concepts of big Earth data.The architecture,various functionalities,and supporting modules are then reviewed from a generic methodology aspect.Analytical methods supporting the functionalities are surveyed and analyzed in the context of different tools.The driven questions are exemplified through cutting-edge Earth science researches and applications.A list of challenges and opportunities are proposed for different stakeholders to collaboratively advance big Earth data analytics in the near future. | Chaowei Yang Manzhu Yu Yun Li Fei Hu Yongyao Jiang Qian Liu Dexuan Sha Mengchao Xu Juan Gu | 2019 | Big Earth Data2019，3，2： | 3 |
| 7 | Insights into the formation of secondary organic carbon in the summertime in urban Shanghai显示文摘To investigate formation mechanisms of secondary organic carbon(SOC) in Eastern China,measurements were conducted in an urban site in Shanghai in the summer of 2015. A period of high O_3 concentrations(daily peak > 120 ppb) was observed, during which daily maximum SOC concentrations exceeding 9.0 μg/(C·m^3). Diurnal variations of SOC concentration and SOC/organic carbon(OC) ratio exhibited both daytime and nighttime peaks. The SOC concentrations correlated well with O_x(= O_3+ NO_2) and relative humidity in the daytime and nighttime, respectively, suggesting that secondary organic aerosol formation in Shanghai is driven by both photochemical production and aqueous phase reactions. Single particle mass spectrometry was used to examine the formation pathways of SOC. Along with the daytime increase of SOC, the number fraction of elemental carbon(EC) particles coated with OC quickly increased from 38.1% to 61.9% in the size range of 250–2000 nm, which was likely due to gas-to-particle partitioning of photochemically generated semi-volatile organic compounds onto EC particles. In the nighttime, particles rich in OC components were highly hygroscopic, and number fraction of these particles correlated well with relative humidity and SOC/OC nocturnal peaks. Meanwhile, as an aqueous-phase SOC tracer, particles that contained oxalate-Fe(III) complex also peaked at night. These observations suggested that aqueous-phase processes had an important contribution to the SOC nighttime formation. The influence of aerosol acidity on SOC formation was studied by both bulk and single particle level measurements, suggesting that the aqueous-phase formation of SOC was enhanced by particle acidity. | Ci Zhang Xiaohui Lu Jinghao Zhai Hong Chen Xin Yang Qi Zhang Qianbiao Zhao Qingyan Fu Fei Sha Jing Jin | 2018 | Journal of Environmental Sciences2018，30，10： | 3 |
| 8 | Microstructure and grain boundary morphology evolution of a novel Co-9Al-9W-2Ta-0.02B alloy doped with yttrium显示文摘The microstructures and grain boundary morphologies of a novel Co-9 Al-9 W-2 Ta-0.02 B alloy doped with yttrium(Y)(0.01,0.05,0.10,and 0.20; at%) were investigated as functions of aging temperatures(900 and1000 ℃) and time(50 and 150 h). The aged alloys all exhibit a γ/γ'-Co_3(Al,W) coherent microstructure in grain interiors, whereas an intermetallic κ-Co_3(W) phase precipitates at grain boundaries. Y is found to fully segregate at grain boundaries and changes grain boundary precipitate morphologies. For 0.01 Y alloy, bright κ-Co_3(W) stripes precipitate along grain boundaries, where a needlelike κ-Co_3(W) phase grows from grain boundaries or κ-Co_3(W) stripes toward grain interior. As the nominal Y content increases, the stripe and needlelike κ-Co_3(W) precipitates at grain boundaries are strongly restrained and disappear in 0.20 Y alloy, leaving fine κ-Co_3(W) particles scattered at grain boundaries. It is noted that more Y segregation may increase the number of low-angle grain boundaries(LABS, with misorientations of <15°), whereas it eliminates O impurities from grain boundaries. Finally,the effect of Y segregation on tensile behavior of Co-AlW-Ta-B alloy was discussed from the viewpoints of grain boundary precipitate morphologies, grain boundary character distribution(GBCD), and impurity segregation. | Jian-Qiang Ma Fei Zhong Shu-Suo Li Jiang-Bo Sha | 2017 | Rare Metals2017，36，12： | 2 |
| 9 | A Platform to Improve Echinococcosis Control in Tibetan Populations-Sichuan Province,China,2015‒2020显示文摘Echinococcosis is a neglected parasitic zoonotic disease that is distributed worldwide.Previous data has shown that China holds the highest disease burden of echinococcosis in the world,resulting in 22.97×10^(5) disability adjusted life year(DALYs)lost annually(1).Echinococcosis is one of the epidemiological factors responsible for poverty in China.Since 2000,China’s central government(CG)has taken several actions to control echinococcosis in Western China.Since 2005. | Tian Tian Shuai Han Chuizhao Xue Xu Wang Shijie Yang Bo Zhong Qian Wang Wenjie Yu Sha Liao Dan Ba Ze Li Wei Li Fei Xie Qiang Wang Zelin Zhu Yuwan Hao Weiping Wu Ning Xiao Xiao-nong Zhou | 2021 | China CDC weekly2021，3，5： | 2 |
| 10 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 11 | Green and economical production of propionic acid by Propionibacterium freudenreichii CCTCC M207015 in plant fibrous-bed bioreactor显示文摘 | Xiaohai Feng Fei Chen Hong Xu Bo Wu Hui Li Sha Li Pingkai Ouyang | 2011 | Bioresource Technology2011，，10： | 1 |
| 12 | Review of Researches on the Protection of Urban Plant Diversity显示文摘With the accelerating urbanization and population explosion, urban ecological environment has been seriously damaged, ecosystem has become unbalanced, and plant diversity has reduced constantly. This paper analyzed domestic and foreign literatures on the protection of urban plant diversity in recent years, summarized the previous researches on the protection of urban plant diversity, and major measures for protecting urban plant diversity. | YI Hong HE Sha ZENG Ting WU Fei WU Tieming | 2015 | Journal of Landscape Research2015，7，1： | 1 |
| 13 | Influence of thermal loading on the dynamic response of thin - walled structure under thermo - acoustic loading显示文摘 | Yundong Sha Zhijun Gao Fei Xu | 2011 | Applied Mechanics and Materials2011，，23： | 1 |
| 14 | Nonlinear response of carbon - carbon composite panels subjected to ther- mal- acoustic loadings 显示文摘 | Yundong Sha Fei Xu Zhijun Gao | 2012 | Applied Mechanics and Materials2012，117，： | 1 |
| 15 | Ionic liquid catalyzed solvent-free synthesis of chalcone and its derivatives under mild conditions显示文摘An ionic liquid(IL)catalyzed solvent-free process was developed for the direct synthesis of chalcone and its derivatives by using substituted acetophenones and benzaldehydes via aldol reaction under mild conditions.A series of acidic and basic ILs were selected and screened.The influences of cations and reaction conditions on product yield and selectivity were systematically investigated.The[Bmim]OH was identified as the optimal IL,with the highest yield and selectivity reaching up to 96.7% and 100%,respectively.A reaction mechanism-based kinetic model was established and regressed with experimental data,revealing the β-Hydroxylketone dehydrolysis with activation barrier of 37.8 kJ·mol^(-1) was observed as the ratecontrolling step. | Qiu Zhao Gang Wang Fuxia Liao Yifan Sha Fei Xu Chunshan Li Zengxi Li Yijun Cao | 2021 | Chinese Journal of Chemical Engineering2021，34，5： | 1 |
| 16 | Influences of thermal loads on nonlinear response of thin-walled structures in thermo-acoustic environment显示文摘 | SHA Yundong GAO Zhijun XU Fei | 2012 | Applied Mechanics and Materials2012，，： | 1 |
| 17 | Multiplicative Updates for Nonnegative Quadratic Programming显示文摘 | Sha Fei Lee D D Saul L K | 2007 | Neural Computation2007，19，8： | 1 |
| 18 | Indirect enzyme linked immunosorbent assay for diagnosis of viable but nonculturable Escherichia coli O157:H7显示文摘 | Yao Fei Sha Sha Chen Gang | 2001 | Journal of Ocean University of Qingdao2001，31，2： | 1 |
| 19 | Safety Evaluation on Fluoride Content in Black Tea显示文摘 | Jin Cao Sha Fei Luo | 2004 | Food Chemistry2004，88，： | 1 |
| 20 | A novel fully automatedon-line coupled liquid chromatography–gaschromatography technique used for the determination oforganochlorine pesticide residues in tobaccoandtobacco products显示文摘 | Qi D W Fei T Sha Y F | 2014 | Journal of Chromatography A2014，1374，： | 1 |
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