|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immune therapy including dendritic cell based therapy in chronic hepatitis B virus infection显示文摘肝炎 B (HBV ) 感染是一个全球公共卫生问题。全球被感染了的约 20 亿个人,超过 4 亿是 HBV 的慢性带菌者。长期的 HBV 搬运人的可观的数字患进步的肝疾病。另外,所有 HBV 搬运人是这个病毒的永久来源。为长期的 HBV 搬运人没有药品治疗。然而,抗病毒的药为大约 10% 病人被推荐这些药是昂贵的,限制了功效,并且拥有可观的副作用。最近的研究证明了到 HBV 的主人的有免疫力的回答非常在长期的 HBV 感染的每个阶段被包含:(1 ) 这些影响长期的 HBV 带菌状态的获得,(2 ) 他们在肝损坏的上下文是重要的,(3 ) 从长期的 HBV 相关的肝疾病的恢复依赖于 HBV 特定的有免疫力的回答的自然和程度。然而,在长期的 HBV 搬运人的 HBV 特定的有免疫力的回答的足够的层次的正式就职是困难的。在最后一十年期间,肝炎 B 疫苗作为一条治疗学的途径(疫苗的治疗) 予长期的 HBV 搬运人被以。疫苗的治疗的现在的政体是安全、便宜,然而并非那么有效。一支树枝状的基于房间的治疗学的疫苗最近为治疗长期的 HBV 感染被开发了。在这评论,我们将为治疗长期的 HBV 感染包括疫苗的治疗和树枝状的基于房间的疫苗的治疗关于 HBV 特定的有免疫力的治疗的开发的概念,科学逻辑,策略和技术讨论。 | Sk Md Fazle Akbar Norio Horiike Morikazu Onji | 2006 | World Journal of Gastroenterology2006，12，18： | 35 |
| 2 | 多级孔分子筛的制备与催化应用显示文摘分子筛研究的热点问题之一是如何减小微孔扩散阻力对传质带来的不利影响,以提高催化剂的利用效率。通过引入介孔,实现多级孔分子筛材料的设计是解决上述问题的一种有效方法。本文介绍了多级孔分子筛材料提高反应扩散效率的理论依据以及国内外多级孔分子筛材料制备方面的研究进展。主要包含'破坏性'方法(destructive methods)和'建设性'方法(constructive methods)的原理,从水热稳定性、酸性、操作性以及可放大性分析了各种合成方法的优势和不足。本文还介绍了多级孔分子筛在催化反应中的若干应用实例,重点介绍了多级孔材料在催化裂化和加氢反应中的应用进展,表明多级孔分子筛可以提高选择性以及转化率。开发适宜酸性以及水热稳定性的微孔-介孔分子筛,同时兼顾低成本、低污染以及易操作性的合成技术是将来研究的重点,同时应建立多级孔分子筛催化性能与结构的关系,加深对多级孔分子筛的认识。 | 彭鹏 张占全 王有和 Fazle Subhan 阎子峰 | 2013 | 化学进展2013，25，12： | 26 |
| 3 | New perspective in statistical modeling of wall-bounded turbulence显示文摘Despite dedicated effort for many decades,statistical description of highly technologically important wall turbulence remains a great challenge.Current models are unfortunately incomplete,or empirical,or qualitative.After a review of the existing theories of wall turbulence,we present a new framework,called the structure ensemble dynamics (SED),which aims at integrating the turbulence dynamics into a quantitative description of the mean flow.The SED theory naturally evolves from a statistical physics understanding of non-equilibrium open systems,such as fluid turbulence, for which mean quantities are intimately coupled with the fluctuation dynamics.Starting from the ensemble-averaged Navier-Stokes(EANS) equations,the theory postulates the existence of a finite number of statistical states yielding a multi-layer picture for wall turbulence.Then,it uses order functions(ratios of terms in the mean momentum as well as energy equations) to characterize the states and transitions between states.Application of the SED analysis to an incompressible channel flow and a compressible turbulent boundary layer shows that the order functions successfully reveal the multi-layer structure for wall-bounded turbulence, which arises as a quantitative extension of the traditional view in terms of sub-layer,buffer layer,log layer and wake. Furthermore,an idea of using a set of hyperbolic functions for modeling transitions between layers is proposed for a quantitative model of order functions across the entire flow domain.We conclude that the SED provides a theoretical framework for expressing the yet-unknown effects of fluctuation structures on the mean quantities,and offers new methods to analyze experimental and simulation data.Combined with asymptotic analysis,it also offers a way to evaluate convergence of simulations.The SED approach successfully describes the dynamics at both momentum and energy levels, in contrast with all prevalent approaches describing the mean velocity profile only.Moreover,the SED theoretical framework is general,independent of the flow system to study, while the actual functional form of the order functions may vary from flow to flow.We assert that as the knowledge of order functions is accumulated and as more flows are analyzed, new principles(such as hierarchy,symmetry,group invariance,etc.) governing the role of turbulent structures in the mean flow properties will be clarified and a viable theory of turbulence might emerge. | Zhen-Su She Xi Chen You Wu Fazle Hussain | 2010 | Acta Mechanica Sinica2010，26，6： | 13 |
| 4 | HBsAg, HBcAg, and combined HBsAg/HBcAg-based therapeutic vaccines in treating chronic hepatitis B virus infection显示文摘BACKGROUND: As the host immunity is diminished in patients with chronic hepatitis B (CHB), different approaches have been used to up-regulate their immune responses to produce therapeutic effects. But, cytokines, growth factors and polyclonal immune modulators could not exhibit sufficient therapeutic effects in these patients. Immune therapy with HBV-related antigens (vaccine therapy) has been used in CHB patients. But there is a paucity of information about the design of HBV antigen-based immune therapy in these patients. DATA SOURCE: Preclinical and clinical studies on immune therapy with HBsAg-based vaccine, HBcAg and combination of HBsAg/HBcAg-based vaccines have been discussed. RESULTS: HBsAg-based prophylactic vaccine was used as an immune therapeutic agent in CHB patients; however, monotherapy with HBsAg-based immune therapy could not lead to sustained control of HBV replication and/or liver damages. HBsAg-based vaccine was used as a combination therapy with cytokines, growth factors, and antiviral drugs. HBsAg-based vaccine was also used for cell-based therapy. However, satisfactory therapeutic effects of HBsAg-based vaccine could not be documented in CHB patients. In the mean time, evidences have supported that HBcAg-specific immunity is endowed with antiviral and liver protecting capacities in CHB patients. Recent data concentrate on the clinical use of combined HBsAg- and HBcAg-based vaccines in CHB patients.CONCLUSION: Antigen-based immune therapy with HBV- related antigens may be an alternative method for the treatment of CHB patients but proper designs of antigens, types of adjuvants, dose of vaccinations, and routes of administration need further analyses for the development of an effective regimen of immune therapy against HBV. | Sheikh Mohammad Fazle Akbar Mamun Al-Mahtab Mohammad Helal Uddin Md. Sakirul Islam Khan | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，4： | 5 |
| 5 | Incorporating boundary constraints to predict mean velocities in turbulent channel flow显示文摘We derive exact near-wall and centerline constraints and apply them to improve a recently proposed LPR model for finite Reynolds number(Re) turbulent channel flows.The analysis defines two constants which are invariant with Re and suggests two more layers for incorporating boundary effects in the prediction of the mean velocity profile in the turbulent channel.These results provide corrections for the LPR mixing length model and incorrect predictions near the wall and the centerline.Moreover,we show that the analysis,together with a set of well-defined sensitive indicators,is useful for assessment of numerical simulation data. | WU You CHEN Xi SHE ZhenSu HUSSAIN Fazle | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，9： | 4 |
| 6 | Generating Adversarial Samples on Multivariate Time Series using Variational Autoencoders显示文摘Classification models for multivariate time series have drawn the interest of many researchers to the field with the objective of developing accurate and efficient models.However,limited research has been conducted on generating adversarial samples for multivariate time series classification models.Adversarial samples could become a security concern in systems with complex sets of sensors.This study proposes extending the existing gradient adversarial transformation network(GATN)in combination with adversarial autoencoders to attack multivariate time series classification models.The proposed model attacks classification models by utilizing a distilled model to imitate the output of the multivariate time series classification model.In addition,the adversarial generator function is replaced with a variational autoencoder to enhance the adversarial samples.The developed methodology is tested on two multivariate time series classification models:1-nearest neighbor dynamic time warping(1-NN DTW)and a fully convolutional network(FCN).This study utilizes 30 multivariate time series benchmarks provided by the University of East Anglia(UEA)and University of California Riverside(UCR).The use of adversarial autoencoders shows an increase in the fraction of successful adversaries generated on multivariate time series.To the best of our knowledge,this is the first study to explore adversarial attacks on multivariate time series.Additionally,we recommend future research utilizing the generated latent space from the variational autoencoders. | Samuel Harford Fazle Karim Houshang Darabi | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，9： | 4 |
| 7 | 两段变温法水热合成多级孔ZSM-5分子筛及其催化裂化性能(英文)显示文摘以四丙基氢氧化铵(TPAOH)为单一模板剂,采用低温老化、高温晶化2段变温法合成出了球状多级孔ZSM-5分子筛。利用XRD、FT-IR、NH_3-TPD、SEM、TEM以及氮气吸-脱附等测试对合成样品进行了表征。结果表明:直径约为2μm左右的球状多级孔ZSM-5分子筛颗粒内的晶间介孔和大孔主要由棒状纳米晶堆积而成的,该产品具有较大的比表面积和介孔孔容。同常规水热法一步合成的微孔ZSM-5分子筛相比,2段变温法合成的多级孔ZSM-5分子筛具有更高的B酸/L酸比例(C_(BP)/C_(LP))、强酸/弱酸比例(C_s/C_w)以及活性位可接近性指数(ACI)。催化裂化评价结果显示,得益于活性位可接近性指数等指标的提高,球状多级孔ZSM-5分子筛比常规合成的微孔ZSM-5分子筛具有更高的转化率和丙烯收率等优异的催化性能。 | 王有和 孙洪满 彭鹏 白鹏 阎子峰 Subhan Fazle 季生福 | 2018 | 无机化学学报2018，34，5： | 3 |
| 8 | In vivo laxative, anti-diarrheal, hepatoprotective and diuretic investigations of Sterculia diversifolia and its isolated compounds显示文摘OBJECTIVE:To investigated the laxative,anti-diarrheal,hepatoprotective and diuretic activity of Sterculia diversifolia and its isolated compounds.METHODS:The laxative activity was studied by counting wet stools while anti-diarrheal activity was performed by measuring gastrointestinal tract motility.Hepatoprotective activity was studied by biochemical and histo-pathological analysis while diuretic activity was performed by urine collection protocol.RESULTS:Doses of 30 and 100 mg/kg of crude methanolic extract of Sterculia diversifolia(MESD)stem bark and leaves,significantly(P<0.05,P<0.01)produced wet feces in subjects pretreated with atropine while 8-hydroxyquercetin and dihydroquercetin showed highly significant(P<0.001)results by increasing fecal weight and water contents without producing diarrhea.MESD stem bark and leaves also dose-dependently lowered diar-rhea while 8-hydroxyquercetin and dihydroquercetin showed highly significant(P<0.001)results by producing shaped stools in mice.MESD,8-hydroxyquercetin and dihydroquercetin offered significant protection against histopathological changes in the liver.Diuretic activity of Crude MESD stem bark and leaves extracts shows highly significant diuretic effect while dihydroquercetin showed better results than 8-hydroxyquercetin.CONCLUSION:It is concluded that Sterculia diversifolia and its isolated compounds bears laxative,anti-diarrheal,hepatoprotective and diuretic effects. | Fazle Rabbi Amir Zada Amna Nisar Muhammad Sohail Saifullah Khan Khalil Abid Ali Ahmad | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 2 |
| 9 | Functional recovery after decompressive craniectomy for cerebral infarction显示文摘 | Kondziolka D Fazl M | 1988 | Neurosurgery1988，23，： | 1 |
| 10 | High growth of SWNTs and MWNTs from C2H2 decomposition over Co-Mo/MgO catalysts显示文摘 | SHAJIHAN M MO Y H FAZLE KIBRIA A K M | 2004 | Carbon2004，42，： | 1 |
| 11 | Contemporary management of anastomotic leak after colon surgery: assessing the need for reoperation显示文摘 | Zhobin Moghadamyeghaneh Mark H. Hanna Reza Fazl Alizadeh Joseph C. Carmichael Steven Mills Alessio Pigazzi Michael J. Stamos | 2015 | The American Journal of Surgery2015，，： | 1 |
| 12 | Intraoperative reduction of locked facets in the cervical spine by use of a modified interlaminar spreader:technical note显示文摘 | FAZL M P1ROUZMAND F | 2001 | Neurosurgery2001，48，： | 1 |
| 13 | Solitary fibrous tumor of the orbit显示文摘 | O'Donovan DA Bilbao JM Fazl M | 2002 | J Creniofac Surg2002，13，5： | 1 |
| 14 | Holographic particle velocimetry:a 3D measurement technique for vortex interactions,coherent structures and turbulence显示文摘 | Meng Hui Hussain Fazle | 1991 | Fluid Dynamics Research1991，8，14： | 1 |
| 15 | Relationship between maternal thyroid hormones and the biochemical markers of the first trimester aneuploidy screening显示文摘 | Hakan Aytan Ahmet C. Caliskan Fazl? Demirturk Semsettin Sahin Filiz Erdogan Zehra Kuzu | 2013 | Archives of Gynecology and Obstetrics2013，，6： | 1 |
| 16 | Intraoperative reduction of locked facets in the cervical spine by use of a modified interlaminat spreader: technical note 显示文摘 | Fazl M Pirouzmand F | 2001 | Neurosurgery2001，48，： | 1 |
| 17 | Enhancement of hydrogen storage capacity of carbon nanotubes via spill-over from vanadium and palladium nanoparticles显示文摘 | Zacharia R Kim K Y Fazle Kibria A K M | 2005 | Chem Phys Lett2005，412，4： | 1 |
| 18 | Small arterial elasticity predicts the extent of coronary artery disease: Relationship with serum uric acid显示文摘 | Murat Fazl?o?lu Tunay ?entürk Ethem Kumbay Aysel Ayd?n Kaderli Yusuf Yilmaz Bülent ?zdemir ?brahim Baran Ali Ayd?nlar | 2008 | Atherosclerosis2008，，1： | 1 |
| 19 | Generalization of adaptive neuro-fuzzy inference systems显示文摘 | Mohammand Fazle Azeem Hanmandlu M Nesar Ahmad | 2000 | IEEE Transactions on Neural Networks2000，11，6： | 1 |
| 20 | Connective tissue growth factor expression hints at aggressive nature of colorectal cancer显示文摘BACKGROUND Connective tissue growth factor(CTGF)is a mediator of transforming growth factor-beta signaling and plays a key role in connective tissue remodeling,inflammatory processes and fibrosis in various illnesses including cancer.AIM To investigate the role of CTGF in colorectal cancer(CRC)progression and to compare the CTGF expression with different clinicopathological parameters.METHODS Real-time polymerase chain reaction,immunohistochemistry and Western blotting was performed to evaluate the CTGF expression and the results were statistically analyzed against the clinicopathological variables of patient data using STATA software version 16.RESULTS CTGF expression levels in tumor specimens were significantly higher than their paired normal specimens.The higher protein expression levels showed a significant association with smoking,staging,tumor grade,invasion depth,necrosis of tumor tissue,and both lymphovascular and perineural invasion.As per the cox regression model and classification tree analysis,tumor-nodemetastasis stage and perineural invasion were important predictors for CTGF expression and prognosis of CRC patients.Survival analysis indicated that CTGF overexpression was associated with poorer overall and disease-free survival.CONCLUSION Expression of CTGF was increased in CRC and was linked with poor overall and disease-free survival of CRC patients.These findings support prior observations and thus CTGF may be a possible prognostic marker in CRC. | Ishrat Parveiz Bhat Tahseen Bilal Rather Irfan Maqbool Gowhar Rashid Kulsum Akhtar Gulzar A Bhat Fazl Q Parray Besina Syed Ishrat Younas Khan Mohsin Kazi Muhammad D Hussain Mudassar Syed | 2022 | World Journal of Gastroenterology2022，28，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员