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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Sepsis stimulates nonlysosomal,energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle显示文摘 | Tiao G Fagan J M Samuels N | 1994 | J Clin Invest1994，94，： | 2 |
| 3 | Histopathologic features of a cochlear implant and otogenic meningitis in Mondini dysplasia显示文摘 | SUZUKI C SANDO I FAGAN J J | 1998 | Arch Otolaryngol Head Neck Surg1998，124，： | 1 |
| 4 | The albumin cobalt binding test:analytical performance of a new automated chemistry 0assay for the detection of ischemia modified albumin(IMA)显示文摘 | Fagan G J Hollie Wayment Deborah L | 2002 | Clin Leg Assay2002，25，5： | 1 |
| 5 | Targets for vascular protection after acute ischemic stroke 显示文摘 | Fagan S C Hess D C Hohnadel E J | 2004 | Stroke2004，35，9： | 1 |
| 6 | Ground arthropod community structure in a heterogeneous urban environment 显示文摘 | MCINTYRE N E RANGO J FAGAN W F | 2001 | Landscape and Urban Planning2001，52，： | 1 |
| 7 | Porewater distribution and benthic flux measurements of mercury and methylmercury in the Gulf of Trieste (Northern Adriatic Sea)显示文摘 | Covelli S Faganeli J Horvat M | 1999 | Estuarine Coastal and Shelf Science1999，48，： | 1 |
| 8 | A comparison-shopper's guide to connectivity metrics显示文摘 | CALABRESE J M FAGAN W F | 2004 | Frontiers in Ecology and the Environment2004，2，10： | 1 |
| 9 | Ground Arthropod Community Structure in a Heterogeneous Urban Environment显示文摘 | McIntyre N E Rango J Fagan W F | 2001 | Landscape and Urban Planning2001，52，： | 1 |
| 10 | Black carbon in Slovenian alpine lacustrine sediments显示文摘 | Muri G Cermelj B Faganeli J | 2002 | Chemo- sphere 2002 46(8): 1225-12342002，46，8： | 1 |
| 11 | Nutritional constraints in terrestrial and freshwater food webs显示文摘 | Elser J J Fagan W F Denno R F | 2000 | Nature2000，408，： | 1 |
| 12 | Ab initiocalculations for a hypothetical material:silicon nanotubes显示文摘 | FAGAN S B BAIERLE R J MOTA R | 2000 | Phys Rev:B2000，61，15： | 1 |
| 13 | Carbon and nitrogen isotope compositions of organic matter in coastal marine sediments (the Gulf of Trieste, N Adriatic Sea) : Indicators of sources and preservation显示文摘 | Ogrinc N Fontolan G Faganeli J | 2005 | Marine Chemistry2005，95，： | 1 |
| 14 | Relationship between dispersion metric and properties of PMMA/SWNT nanoc0mposites显示文摘 | Kashiwagi T Fagan J Douglas J F | 2007 | Polymer2007，48，16： | 1 |
| 15 | Mercury in Contaminated Coastal Environments:A Case Study:The Gulf of Trieste显示文摘 | Horvat M Covelli S Faganeli J | 1999 | The Science of the Total Environment1999，，： | 1 |
| 16 | Phase distribution identification in the column leaching of low grade ores using MRI显示文摘 | FAGAN M A SEDERMAN A J HARRISON S T L JOHNS M L | 2013 | Minerals Engineering2013，48，： | 1 |
| 17 | Ground arthropod community structure in a heterogeneous urban environment显示文摘 | Mclntyre N E Rango J Fagan W F Faeth S H | 2001 | Landscape and Urban Planning2001，52，： | 1 |
| 18 | Biological stoichiometry of plant production: metabolism, scaling and ecological response to global change显示文摘 | ELSER J J FAGAN W F KERKHOFF A J | 2010 | New Phytologist2010，186，3： | 1 |
| 19 | Performance assessment under field condition of a rapid immunological test for transgenic soybeans显示文摘 | FAGAN J HEID C A AHMED B | 2001 | Int J Food Soi Technol2001，36，2： | 1 |
| 20 | Total mercury and methylmercury and selenium in mercury polluted areas in Guizhou Province,China显示文摘 | Horvat M Nolde N Fajon V Jereb V Logar M Lojen S Jacimovic R Falnoga I Qu Liya Faganeli J DrobneD | 2003 | Science of Total Environment2003，304，： | 1 |
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