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| 1 | Oxidation state specific analysis of arsenic species in tissues of wild-type and arsenic(+3 oxidation state)methyltransferase-knockout mice显示文摘Arsenic methyltransferase(As3mt) catalyzes the conversion of inorganic arsenic(i As) to its methylated metabolites, including toxic methylarsonite(MAs~Ⅲ) and dimethylarsinite(DMAs~Ⅲ). Knockout(KO) of As3 mt was shown to reduce the capacity to methylate i As in mice. However, no data are available on the oxidation states of As species in tissues of these mice. Here, we compare the oxidation states of As species in tissues of male C57BL/6 As3mt-KO and wild-type(WT) mice exposed to arsenite(iA s~Ⅲ) in drinking water. WT mice were exposed to50 mg/L As and As3mt-KO mice that cannot tolerate 50 mg/L As were exposed to 0, 15, 20, 25 or30 mg/L As. iA s~Ⅲaccounted for 53% to 74% of total As in liver, pancreas, adipose, lung, heart, and kidney of As3mt-KO mice; tri- and pentavalent methylated arsenicals did not exceed 10% of total As. Tissues of WT mice retained iA s and methylated arsenicals: iA s~Ⅲ, MAs~Ⅲand DMAs~Ⅲ represented 55%‐68% of the total As in the liver, pancreas, and brain. High levels of methylated species, particularly MAs~Ⅲ, were found in the intestine of WT, but not As3mt-KO mice,suggesting that intestinal bacteria are not a major source of methylated As. Blood of WT mice contained significantly higher levels of As than blood of As3mt-KO mice. This study is the first to determine oxidation states of As species in tissues of As3mt-KO mice. Results will help to design studies using WT and As3mt-KO mice to examine the role of iA s methylation in adverse effects of iA s exposure. | Jenna M.Currier Christelle Douillet Zuzana Drobná Miroslav Styblo | 2016 | Journal of Environmental Sciences2016，28，11： | 8 |
| 2 | Acute biliary pancreatitis:detection of common bile duct stones with endoscopic ultrasound显示文摘 | Stabuc B Drobne D Ferkolj I | 2008 | Eur J Gastroenterol Hepatol2008，20，12： | 1 |
| 3 | Total mercury and methylmercury and selenium in mercury polluted areas in Guizhou Province,China显示文摘 | Horvat M Nolde N Fajon V Jereb V Logar M Lojen S Jacimovic R Falnoga I Qu Liya Faganeli J DrobneD | 2003 | Science of Total Environment2003，304，： | 1 |
| 4 | Ultrastructural alterations of the hepatopancreas in Porcellio scaber under stress显示文摘 | Znidar ic Nada trus Jasna Drobne Damjana | 2003 | Environmental Toxicology and Pharmacology2003，13，3： | 1 |
| 5 | The applicability of ace- tylcholinesterase and glutathione S-transferase in Dcrphnia magna toxicity test 显示文摘 | Jemec A Drobne D Tigler T | 2007 | Comparative Biochemistry and Phys- iology Part C: Toxicology & Pharmacology2007，144，4： | 1 |
| 6 | Electron and ion imaging of gland cells using the FIB/SEM system 显示文摘 | Drobne D Milani M Zrimec A | 2005 | Journal of Microscopy2005，219，： | 1 |
| 7 | Cavity QEDwith Cold Trapped lons显示文摘 | BUZEK V DROBN G KIM M S etal | 1997 | PhysRevA1997，56，： | 1 |
| 8 | Zn, Cd and Pb accumulation and arbuscular mycorrhizal colonisation of pennycres Thlapi praecox Wulf (Brassicaceae)from the vicinity of a lead mine and smelter in Slovenia显示文摘 | Vogel-Mikus K Drobne D Regvar M | 2005 | Environment Pollution2005，133，2： | 1 |
| 9 | Primary oxidation of organic matter in the soil显示文摘 | J. Drobník | 1960 | Plant and Soil1960，，3： | 1 |
| 10 | Gut bacterial com-munity structure ( porcellio scaber,isopoda,crustacean )as a measure of community level response to long-termand short-term metal pollution显示文摘 | LAPANJE A RUPNIL M DROBNE D | 2007 | Environmental Toxi-cology and Chemistry2007，26，4： | 1 |
| 11 | Simple solid-phase extraction method for determination of polychlorinated biphenyls and selected organochlorine pesticides in human serum显示文摘 | Aonka A K Drobn A A | 2005 | Chromatography A2005，1084，： | 1 |
| 12 | The applicability of acetylcholinesterase and glutathione S-transferase in Daphnia magna toxicity test显示文摘 | Jemec A Drobne D Tiller T | 2007 | Comparative Biochemistry and Physiology Part C2007，144，： | 1 |
| 13 | The applicability of acetylcholinesterase and glutathione S-transferase in Daphnia magna toxicity test显示文摘 | JEMEC A DROBNE D TISLER T | 2007 | Comparative Biochemistry and Physiology:Part C2007，144，： | 1 |
| 14 | Bioaeeumulation in Porcellio scaber (Crustacea, lsopoda) as a measure of the EDTA remediafion efficiency of metal-polluted soil显示文摘 | UDOVIC M DROBNE D LESTAN D | 2009 | Environmental Pollution2009，157，10： | 1 |
| 15 | Acute biliary pancreatitis: detection of common bile duct stones with endoscopic ultrasound 显示文摘 | Stabuc B Drobne D Ferkolj I | 2008 | Eur J Gastroenterol Hepatol2008，20，12： | 1 |
| 16 | Surface damage induced by FIB milling and imaging of biological sample is controllable 显示文摘 | Drobne D Milani M Leser V Tatti F | 2007 | Microscopy Research and Technique2007，70，： | 1 |
| 17 | Acute biliary pancreatitis:detection of common bile duct stones with endoscopic ultrasound显示文摘 | Stabuc B Drobne D Ferkolj I | 2008 | Eur J Gastroenterol Hepatol2008，20，12： | 1 |
| 18 | Moult frequency of the isopod Porcellio scaber, as a measure of zinc-contaminated food显示文摘 | Drobne D Strus J | 1996 | Environ Toxicol Chem1996，15，： | 1 |
| 19 | Electron and ion imaging of gland cells using the FIB/SEM system显示文摘 | Drobne D Milani M Zrimec A | 2005 | Journal of Microscopy2005，219，1： | 1 |
| 20 | Simple solidphase extraction method for determination of polychlorinated biphenyls and selected organochlorine pesticides in human serum显示文摘 | ONKA K DROBN B KO AN A | 2005 | J Chromatogr A2005，1084，12： | 1 |
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