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您的检索式：作者名="Eldo E Frezza"
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| 1 | Loss expression of active fragile sites genes associated with the severity of breast epithelial abnormalities显示文摘背景 WWOX 和 FHIT 是位于活跃易碎的地点,其损坏与乳癌的发展被联系了的二候选人肿瘤 suppressor 基因。这些基因的表达式和乳癌的开发的协会充分没被探索。我们与正常组织学的外观在胸织物评估了 mRNA 和 WWOX 和 FHIT 的蛋白质表示,不正常的 ductal 增生,在 situ 的 ductal 癌,并且看在表示的进步衰落是否是 present.Methods 颠倒抄写聚合酶链反应并且西方的弄污的侵略癌症被用来为 mRNA 和蛋白质表示评估标本包括有正常织物的 28 个标本,有不正常的 ductal 增生的 28 个标本,有 ductal 的 33 个标本汽车结果与相比在 situ 和侵略癌症标本,正常、不正常的增生标本有可检测的 mRNA 的更大的率(WWOX 率 ratio=2.95, 95% CI 1.24-7.08;FHIT 率 ratio=4.58, 95% Cl 1.82-11.81 ) 并且西方的弄污的可检测的蛋白质(WWOX 率 ratio=4.12, 95% Cl 1.63-10.73;FHIT 率 ratio=3.76, 95% Cl 1.44-10.06 ) 。为两蛋白质,正常、不正常的增生标本之间并且在之间的差别在 situ 和侵略的癌,标本碰巧是可解说的(P > 0.05 为每分析) 。在每个组织学的范畴以内,在标本的部分之中的差别显示出那 FHIT 和 WWOX mRNA。并且蛋白质表示碰巧是可解说的(P > 0.05 为每分析) FHIT 和 WWOX 的 .Conclusion 表示从正常组织学的外观与胸织物进步一起减少到不正常的 ductal 增生在 situ 癌症,并且最后的侵略癌症。 | WANG Tian-tian Eldo E Frezza MA Rong HU San-yuan LIU Chong-zhong ZHANG Guang-yong Mitchell S. Wachtel LU Xiao-mei FENG Jin-bo LU Cui-xia | 2008 | Chinese Medical Journal2008，，20： | 2 |
| 2 | Immunological treatment of liver tumors显示文摘Although multiple options for the treatment of liver tumors have often been described in the past, including liver resection, radiofrequency ablation with or without hepatic pump insertion, laparoscopic liver resection and the use of chemotherapy, the potential of immunotherapy and gene manipulation is still largely unexplored.Immunological therapy by gene manipulation is based on the interaction between virus-based gene delivery systems and dendritic cells. Using viruses as vectors, it is possible to transduce dendritic cells with genes encoding tumor-associated antigens, thus inducing strong humoral and cellular immunity against the antigens themselves.Both chemotherapy and radiation therapy have the disadvantage of destroying healthy cells, thus causing severe side-effects. We need more precisely targeted therapies capable of killing cancer cells while sparing healthy cells. Our goal is to establish a new treatment for solid liver tumors based on the concept of cytoreduction,and propose an innovative algorithm. | Maurizio Chiriva-Internati Fabio Grizzi Cynthia A Jumper Everardo Cobos Paul L Hermonat Eldo E Frezza | 2005 | World Journal of Gastroenterology2005，11，42： | 1 |
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