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您的检索式：作者名="Stuart Bloom"
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| 1 | Levofloxacin/amoxicillin-based schemes vs quadruple therapy for Helicobacter pylori eradication in second-line显示文摘Worldwide prevalence of Helicobacter pylori(H.pylori) infection is approximately 50%,with the highest being in developing countries.We compared cure rates and tolerability(SE) of second-line anti-H.pylori levofloxacin/amoxicillin(LA)-based triple regimens vs standard quadruple therapy(QT).An English language literature search was performed up to October 2010.A meta-analysis was performed including randomized clinical trials comparing 7-or 10-d LA with 7-d QT.In total,10 articles and four abstracts were identified.Overall eradication rate in LA was 76.5%(95% CI:64.4%-97.6%).When only 7-d regimens were included,cure rate was 70.6%(95% CI:40.2%-99.1%),whereas for 10-d combinations,cure rate was significantly higher(88.7%;95% CI:56.1%-109.9%;P < 0.05).Main eradication rate for QT was 67.4%(95% CI:49.7%-67.9%).The 7-d LA and QT showed comparable efficacy [odds ratio(OR):1.09;95% CI:0.63-1.87],whereas the 10-d LA regimen was significantly more effective than QT(OR:5.05;95% CI:2.74-9.31;P < 0.001;I 2 = 75%).No differences were reported in QT eradication rates among Asian and European studies,whereas LA regimens were more effective in European populations(78.3% vs 67.7%;P = 0.05).Incidence of SE was lower in LA therapy than QT(OR:0.39;95% CI:0.18-0.85;P = 0.02).A higher rate of side effects was reported in Asian patients who received QT.Our findings support the use of 10-d LA as a simple second-line treatment for H.pylori eradication with an excellent eradication rate and tolerability.The optimal second-line alternative scheme might differ among countries depending on quinolone resistance. | Simona Di Caro Lucia Fini Yayha Daoud Fabio Grizzi Antonio Gasbarrini Antonino De Lorenzo Laura Di Renzo Sara McCartney Stuart Bloom | 2012 | World Journal of Gastroenterology2012，18，40： | 9 |
| 2 | Henoch-Schnlein purpura complicating adalimumab therapy for Crohn's disease显示文摘Anti-tumour necrosis factor-α(TNF) therapy has revolutionised the management of chronic inflammatory conditions.With ever increasing numbers of patients being treated with these agents,uncommon adverse reactions will inevitably occur more frequently.Cutaneous manifestations are associated with many of these chronic conditions and can complicate anti-TNF therapy in about 20% of cases.Vasculitic complications are rarely associated with anti-TNF therapy.Henoch-Schnlein purpura(HSP),a small vessel vasculitis,has been described following infliximab and etanercept therapy but never with adalimumab,a fully humanized TNF antibody.The risk of such immune-mediated reactions is theoretically less with adalimumab compared to infliximab but can still occur.Here we report the f irst case in the literature of HSP that can be attributed to the use of adalimumab in a 19-year-old male with recalcitrant Crohn's disease. | Farooq Z Rahman Gagandeep K Takhar Ovishek Roy Anna Shepherd Stuart L Bloom Sara A McCartney | 2010 | World Journal of Gastrointestinal Pharmacology and Therapeutics2010，1，5： | 1 |
| 3 | High resolution colonoscopy in a bowel cancer screening program improves polyp detection显示文摘AIM:To compare high resolution colonoscopy(Olympus Lucera) with a megapixel high resolution system(Pentax HiLine) as an in-service evaluation.METHODS:Polyp detection rates and measures of performance were collected for 269 colonoscopy procedures.Five colonoscopists conducted the study over a three month period,as part of the United Kingdom bowel cancer screening program.RESULTS:There were no differences in procedure duration(χ2 P = 0.98),caecal intubation rates(χ2 P = 0.67),or depth of sedation(χ2 P = 0.64).Mild discomfort was more common in the Pentax group(χ2 P = 0.036).Adenoma detection rate was significantly higher in the Pentax group(χ2 test for trend P = 0.01).Most of the extra polyps detected were flat or sessile adenomas.CONCLUSION:Megapixel definition colonoscopes improve adenoma detection without compromising other measures of endoscope performance.Increased polyp detection rates may improve future outcomes in bowel cancer screening programs. | Matthew R Banks Rehan Haidry M Adil Butt Lisa Whitley Judith Stein Louise Langmead Stuart L Bloom Austin O' Bichere Sara McCartney Kalpesh Basherdas Manuel Rodriguez-Justo Laurence B Lovat | 2011 | World Journal of Gastroenterology2011，17，38： | 1 |
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