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| 1 | Antioxidants,inflammation and cardiovascular disease显示文摘Multiple factors are involved in the etiology of cardiovascular disease(CVD). Pathological changes occur in a variety of cell types long before symptoms become apparent and diagnosis is made. Dysregulation of physiological functions are associated with the activation of immune cells,leading to local and finally systemic inflammation that is characterized by production of high levels of reactive oxygen species(ROS). Patients suffering from inflammatory diseases often present with diminished levels of antioxidants either due to insufficient dietary intake or,and even more likely,due to increased demand in situations of overwhelming ROS production by activated immune effector cells like macrophages. Antioxidants are suggested to beneficially interfere with diseases-related oxidative stress,however the interplay of endogenous and exogenous antioxidants with the overall redox system is complex. Moreover,molecular mechanisms underlying oxidative stress in CVD are not fully elucidated. Metabolic dybalances are suggested to play a major role in disease onset and progression. Several central signalingpathways involved in the regulation of immunological,metabolic and endothelial function are regulated in a redox-sensitive manner. During cellular immune response,interferon γ-dependent pathways are activated such as tryptophan breakdown by the enzyme indoleamine 2,3-dioxygenase(IDO) in monocyte-derived macrophages,fibroblasts,endothelial and epithelial cells. Neopterin,a marker of oxidative stress and immune activation is produced by GTP-cyclohydrolase Ⅰ in macrophages and dendritic cells. Nitric oxide synthase(NOS) is induced in several cell types to generate nitric oxide(NO). NO,despite its low reactivity,is a potent antioxidant involved in the regulation of the vasomotor tone and of immunomodulatory signaling pathways. NO inhibits the expression and function of IDO. Function of NOS requires the cofactor tetrahydrobiopterin(BH4),which is produced in humans primarily by fibroblasts and endothelial cells. Highly toxic peroxynitrite(ONOO-) is formed solely in the presence of superoxide anion(O2-). Neopterin and kynurenine to tryptophan ratio(Kyn/Trp),as an estimate of IDO enzyme activity,are robust markers of immune activation in vitro and in vivo. Both these diagnostic parameters are able to predict cardiovascular and overall mortality in patients at risk. Likewise,a significant association exists between increase of neopterin concentrations and Kyn/Trp ratio values and the lowering of plasma levels of vitamin-C,-E and-B. Vitamin-B deficiency is usually accompanied by increased plasma homoycsteine. Additional determination of NO metabolites,BH4 and plasma antioxidants in patients with CVD and related clinical settings can be helpful to improve the understanding of redox-regulation in health and disease and might provide a rationale for potential antioxidant therapies in CVD. | Harald Mangge Kathrin Becker Dietmar Fuchs Johanna M Gostner | 2014 | World Journal of Cardiology2014，6，6： | 25 |
| 2 | 信息资本主义及互联网的劳工显示文摘本文认为在信息资本主义中,阶级的概念不能画地为牢地将资本家归为一个阶级,而将劳工划为另一类阶级。阶级的概念必须扩展到每位创造以及再创造共同经验空间的个人,例如包括在互联网上通过实践生产内容的用户。这些空间和经验被占用了,从而为资本所征用和开发,且为资本积累效劳。信息资本主义的崛起要求我们重新思考阶级的概念并将其与脑力劳动结合起来。 | Christian Fuchs 陈婉琳(译) 黄炎宁(译) | 2014 | 新闻大学2014，，5： | 19 |
| 3 | 颈椎前路减压术合并椎动脉损伤显示文摘目的 探讨颈椎前路减压术中椎动脉损伤的危险因素及其处理方法。方法 1980年 1月~ 1998年 12月,对 720例患者行颈椎前路减压术,减压范围包括 1~ 3个椎间隙并行椎体次全切除。术中采用高速磨钻切除骨及椎间盘组织。 630例患者同时行颈椎前路 Caspar钢板内固定术。 3例行椎间减压时向侧方切除过多,导致椎动脉损伤,采用明胶海绵加游离肌片局部填塞止血。结果 720例中椎动脉损伤发生率为 0.4%, 3例均压迫止血成功,无一例出现脑缺血等神经系统症状。结论 颈椎前路减压时不应跨越钩椎关节,局部明胶海绵加游离肌片填塞是有效的椎动脉止血方法。 | 任先军 Caspar W Fuchs GA | 2000 | 中华骨科杂志2000，20，8： | 16 |
| 4 | Proposal of an ultrasonographic classification for hepatic alveolar echinococcosis: Echinococcosis multilocularis Ulm classification-ultrasound显示文摘AIM: To establish an ultrasonographic classification based on a large sample of patients with confirmed hepatic alveolar echinococcosis(AE).METHODS: Clinical data and ultrasonography(US) findings of 185 patients(100 males; 85 females; mean age at diagnosis: 51.4 ± 17.6 years; mean age at time of US examination: 58.7 ± 18.2 years) were retrospectively reviewed with respect to the US morphology of hepatic AE lesions. The sonomorphological findings were grouped according to a five-part classification scheme.RESULTS: Application of the new classification resulted in the following distribution of sonomorphological patterns among the patients examined: hailstorm(54.1%); pseudocystic(13.5%); ossification(13.0%); hemangioma-like(8.1%); and metastasis-like(6.5%). Only 4.9% of lesions could not be assigned to a sonomorphological pattern.CONCLUSION: The sonomorphological classification proposed in the present study facilitates the diagnosis,interpretation and comparison of hepatic alveolar echinococcosis in routine practice and in the context of scientific studies. | Wolfgang Kratzer Beate Gruener Tanja EM Kaltenbach Sarina Ansari-Bitzenberger Peter Kern Michael Fuchs Richard A Mason Thomas FE Barth Mark M Haenle Andreas Hillenbrand Suemeyra Oeztuerk Tilmann Graeter | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 5 | Sedimentation acceleration of remanent iron oxide by magnetic flocculation显示文摘Sedimentation based processes are widely used in industry to separate particles from a liquid phase. Since the advent of the 'Nanoworld' the demand for effective separation technologies has rapidly risen, calling for the development of new separation concepts, one of which lies in hybrid separation using the superposition of a magnetic field for magnetic particles. Possible product portfolio of such separation consists of pigment production, nanomagnetics production for electronics and bio separation. A promising step in that direction is magnetic field enhanced cake filtration, which has by now progressed from batch to continuous operation. In sedimentation processes in a mass force field the settling behaviour of particles strongly depends on physico-chemical properties, concentration and size distribution of the particles. By adjusting the pH, the interparticle forces, in particular the electrostatic repulsion, can be manipulated. For remanent magnetic particles such as magnetite, pre-treatment in a magnetic field could lead to a change of interparticle interactions. By magnetizing the particles apart from van der Waals attraction and electrostatic repulsion, an additional potential is induced, the magnetic attraction, which could easily dominate the other potentials and result in agglomeration in the primary minimum. By sedimentation analysis, a wide spectrum of parameters like pH, magnetic field strength and concentration have been investigated. The results show a strong increase of sedimentation velocity by magnetic flocculation of the raw suspension. This leads to a rise in throughput due to the acceleration of sedimentation kinetics by imparting a non-chemical interaction to the physico-chemical properties in the feed stream of the separation apparatus. | Mathias Stolarski Christian Eichholz Benjamin Fuchs Hermann Nirschl | 2007 | China Particuology2007，5，1： | 12 |
| 6 | WONCA研究论文摘要汇编——老年患者因患多种疾病接受全科诊疗时的自感健康状况:一项在德国进行的横断面研究显示文摘背景随着预期寿命的延长,罹患多种疾病的人数也在上升。然而在患有多种疾病的人群中,了解生活质量健康影响因素者寥寥无几。本试验旨在确定老年患者因患多种疾病接受基层医疗服务时,与其自感健康状况(SRH)相关的影响因素。方法从德国境内的8个研究中心158个全科医疗点中,选出因患多种疾病接受基层医疗服务、年龄65~85岁的3 189例老年患者进行横断面研究。通过面对面的访谈,收集有关患病情况、危险因素、智力水平、机体功能状态以及社会经济状况的资料。 | Nützel A Dahlhaus A Fuchs A 周淑新 | 2014 | 中国全科医学2014，17，17： | 10 |
| 7 | 西方蜜蜂幼虫发育温度对成体翅膀形态的影响(英文)显示文摘为探讨不同恒定温度条件对培育蜜蜂蛹翅膀形态特征的影响,作者将进入蛹期的西方蜜蜂(Apismellifera)放入人工气候箱里,分别在32、35和36℃的恒定温度条件培育,直到蜜蜂蛹羽化出房为止。测量了蜜蜂翅膀的标准形态特征,包括翅的大小、肘脉长和11个翅肘脉角,所得到的数据进行多变量比较分析、相关性分析、主成分分析和区别分析。研究结果表明。 | 谭垦 Fiola BOCK Stefan FUCHS Sebastian STREIT Axel BROCKMANN Juergen TAUTZ | 2005 | 动物学报2005，51，4： | 7 |
| 8 | 维生素D对心力衰竭患者全因死亡率的影响:4000U/d维生素D口服3年随机临床试验结果显示文摘循环25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]〈75nmol/L与死亡率风险的非线性增加相关。这种低25(OH)D水平在心力衰竭患者中很常见。因此,Zittermann等进行研究检查口服维生素D补充剂能否降低晚期心力衰竭患者的死亡率。 | 刘莉 叶鹏 Zittermann A Ernst JB Prokop S Fuchs U Dreier J Kuhn J Knabbe C Birschmann I Schulz U Berthold HK Pilz S Gouni-Berthold I Gummert JF Dittrich M Brgermann J | 2017 | 中华高血压杂志2017，25，10： | 7 |
| 9 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 10 | Higher Predicted Vitamin D Status Is Associated With Reduced Risk of Crohn’s Disease显示文摘 | Ashwin N. Ananthakrishnan Hamed Khalili Leslie M. Higuchi Ying Bao Joshua R. Korzenik Edward L. Giovannucci James M. Richter Charles S. Fuchs Andrew T. Chan | 2012 | Gastroenterology2012，，3： | 6 |
| 11 | 标准辅助化疗基础上增加塞来昔布或安慰剂对Ⅲ期结肠癌患者无复发生存的疗效对比研究:CALGB/SWOG 80702(Alliance)随机对照研究显示文摘背景:既往观察性和随机对照研究已表明阿司匹林和环氧化酶-2(COX-2)抑制剂可降低肠道息肉和肠癌的发生风险。COX-2抑制剂塞来昔布治疗非转移性结肠癌的效果尚未明确。目的:本研究旨在明确FOLFOX辅助化疗基础上增加塞来昔布是否能提高Ⅲ期结肠癌患者的无复发生存率。方法:本研究为在美国、加拿大的654个中心开展的采用2×2析因设计的Ⅲ期临床研究,从2010年6月至2015年11月共纳入2526例Ⅲ期结肠癌患者,随访时间截止为2020年8月10日。以化疗时长和是否接受塞来昔布治疗作为2个随机因素,入组患者被随机分配接受3个月或6个月的FOLFOX辅助化疗(每两周1次)及随机接受联合3年塞来昔布(400 mg QD,n=1263)或安慰剂(n=1261)治疗。主要终点测量指标为3年无复发生存率(DFS),次要终点测量指标包括总生存、不良反应及心血管特异性不良事件。本次仅报道以是否接受塞来昔布治疗的随机分组研究结果。结果:入组患者平均年龄(61±11)岁,1134例(44.9%)为女性,最终2524例被纳入初步分析。患者治疗方案依从性(即接受塞来昔布或安慰剂治疗2.75年以上或持续治疗至复发、死亡或不可接受的不良事件)在塞来昔布组和安慰剂组分别为70.8%和69.9%。经过6年中位随访期,塞来昔布组和安慰剂组各有337例和363例患者出现疾病复发或死亡,3年无复发生率分别为76.3%和73.4%(疾病复发或死亡风险比HR=0.89,95%CI:0.76~1.03,P=0.12)。塞来昔布治疗对DFS的影响不会因辅助化疗时长(3个月或6个月)而存在差异(交互作用P=0.61)。两组5年生存率分别为84.3%和81.6%(死亡风险比HR=0.86,95%CI:0.72~1.04,P=0.13)。任何级别的高血压病发生率在塞来昔布组和安慰剂组分别为14.6%和10.9%,而2级或以上肌酐水平升高的发生率在两组分别为1.7%和0.5%。结论:对于Ⅲ期结肠癌患者,在标准辅助化疗的基础上联合3年塞来昔布治疗与安慰剂比较,对患者无复发生存率的改善不明显。 | 邱萌 MEYERHARDT J A SHI Q FUCHS C S | 2021 | 结直肠肛门外科2021，27，3： | 6 |
| 12 | 声激励下自由射流的涡量场显示文摘本文目的是研究声激励对自由射流流场结构的影响。采用多重网格方法对声激励下三维自由射流(Re=2200)的空间演化做大涡模拟。比较了无激励情况和不同频率声激励下射流涡量场的改变。计算表明,当声激励频率接近射流优势频率时,涡量场结构变化显著。周向涡量集中卷起形成大的涡环,射流径向扩展增大。当激励频率接近优势频率两倍时,有涡合并现象,说明出现次谐波。当激励频率远高于优势频率时,流场结构与无激励情况差别不大。本文还给出在接近优势频率的激励下射流中的流向涡量的分布,定性上与实验观察相同。 | 朱旻明 赵平辉 陈义良 白雪松 Laszlo Fuchs | 2012 | 工程热物理学报2012，33，10： | 5 |
| 13 | Effect of No-Reflow During Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction on Six-Month Mortality显示文摘 | David Brosh Abid R. Assali Aviv Mager Avital Porter David Hasdai Igal Teplitsky Eldad Rechavia Shmuel Fuchs Alexander Battler Ran Kornowski | 2007 | The American Journal of Cardiology2007，，4： | 4 |
| 14 | A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers显示文摘 | Katsuhiko Nosho Shoko Kure Natsumi Irahara Kaori Shima Yoshifumi Baba Donna Spiegelman Jeffrey A. Meyerhardt Edward L. Giovannucci Charles S. Fuchs Shuji Ogino | 2009 | Gastroenterology2009，，5： | 4 |
| 15 | Phase II Study of Everolimus in Patients with Metastatic Colorectal Adenocarcinoma Previously Treated with Bevacizumab-, Fluoropyrimidine-, Oxaliplatin-, and Irinotecan-Based Regimens显示文摘 | Kimmie Ng Josep Tabernero Jimmy Hwang Emilio Bajetta Sunil Sharma Salvatore A. Del Prete Edward R. Arrowsmith David P. Ryan Michaela Sedova Jin Jin Kamel Malek Charles S. Fuchs | 2013 | Clinical Cancer Research2013，，14： | 4 |
| 16 | 美国杜克大学护理发展卓越中心院校合作介绍及启示显示文摘介绍美国杜克大学护理发展卓越中心的成立背景、组织目标和架构以及工作内容,为深入推动中国护理院校合作提供借鉴。 | 成磊 Staci Reynolds Mary Ann Fuchs Marion Broome | 2019 | 中华护理杂志2019，54，3： | 4 |
| 17 | 传统中药在欧洲的市场商机显示文摘DrFuchs现任华牌咨询(CHINABRANDConsultingLinited)的业务主管,CHINABRANDConsultingLimited为中国企业经营运作提供有效建议与有力支持。该咨询机构在英国伯明翰,德国慕尼黑及中国上海设有分部,基于详尽的市场调查分析,可开发并提供全新建议设想与生产管理理念,使中国中医药企业在欧洲及其他国家市场上具有良好销售前景。CHINABRAND可作为中国企业在欧洲的研发部门操作业务。除此之外,CHINABRAND还将支持中国其企业在欧洲市场的品牌建立及后续管理,市场营销及市场销售,进行诸如寻找业务伙伴、公共关系、销售终端的促销活动等业务操作。 | Hans Joachim Fuchs 杨笑阳 | 2005 | 中国中药杂志2005，30，18： | 4 |
| 18 | 钛合金网架髋臼重建术显示文摘目的观察自体植骨 ,钛合金网架重建内陷性髋臼的临床效果。方法1993年1月~1995年8月 ,25侧内陷性髋臼应用局部自体植骨 ,钛合金网架重建术。男11髋 ,女14髋 ,年龄45~76岁 ,平均69岁。术前诊断类风湿性关节炎11髋 ,骨关节炎8髋 ,股骨头缺血性坏死4髋 ,髋臼发育不良2髋。平均随访4.5年 (3~5年 )。结果25髋按Merled Aubigne标准评分,平均为10.2分 ,优良率88 % ,全部植骨获得骨性融合。无髋臼帽松动 ,髋臼内壁无一发生骨折或金属网架断裂。结论自体植骨同时用钛合金网架加固 ,能有效重建内陷性髋臼。 | 任先军 GA Fuchs Juergen Wacker | 2000 | 中华骨科杂志2000，20，4： | 3 |
| 19 | 鸵鸟皮:珍奇的羽孔粒面显示文摘较为系统地叙述了鸵鸟的种类和分布,以及非洲鸵、美洲鸵和鸸鹋皮的特性。详细地介绍了鸵鸟皮的加工工艺,从鸵鸟皮的浸水、去肉开始,一直到浸酸鞣制以及染色后的整理涂饰。对鸵鸟皮的加工生产具有一定的指导意义。 | Karl-Heinz Fuchs Manuel Fuchs 刘鹏杰(译) | 2007 | 中国皮革2007，36，1： | 3 |
| 20 | 用于大型汽轮发电机定子绕组固定部件的玻璃纤维增强塑料显示文摘用作绝缘部件的玻璃纤维增强塑料定要在高温下承受机械应力。本文叙述了由玻璃纤维毡和粗纱布制成的,高质量纤维增强的Vetresit层压板的性能。层压板在发电机线圈端部有各种不同的应用。 | Fuchs,H 隋银德 | 1994 | 国外大电机1994，，2： | 3 |
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