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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 3 | Development of a PCR ELISA assay for the identification of Campylobacter jejuni and Campylobacter coli 显示文摘 | SAILS A D FOX A J BOLTON F J | 2001 | Mol Cell Probe2001，15，： | 1 |
| 4 | The role of oral micro- bial colonization in ventilator-associated pneumonia显示文摘 | Brennan MT Bahrani-Mougeot F Fox PC | 2004 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2004，98，6： | 1 |
| 5 | Augumented gentamycin otoxicity induced by vancomycin in guinea pigs 显示文摘 | Brummett RE Fox KE Jacobs F | 1990 | Arch Otolaryngol head Neck Surg1990，116，1： | 1 |
| 6 | Photophysics of 10-substi- tuted poly ( 2-(9-anthryl) ethyl methacrylates) 显示文摘 | Marye Anne Fox Phillip F Britt | 1990 | Macro- molecules1990，23，21： | 1 |
| 7 | Degeneration and ru- pture of the Achilles tendon显示文摘 | Fox JM Blazina M Jobe F | 1975 | Clin Orthop1975，107，： | 1 |
| 8 | An apparently new transmissible disease of cattle显示文摘 | OLAFSON P MAC C A FOX F H | 1946 | Cornell Vet1946，36，： | 1 |
| 9 | Significance and applications of phenolic compounds in the production and quality of milk and dairy products:a review显示文摘 | O' Connell J E Fox P F | 2001 | Int Dairy J2001，，11： | 1 |
| 10 | Synthesis and characterization of copper-doped carbon aerogels显示文摘 | BAUMANN T F FOX G A SATCHER J H | 2002 | Langmuir2002，18，： | 1 |
| 11 | Saccular aneurysms in basilar artery fenestration 显示文摘 | Campos j Fox A J Vinuela F | 1987 | Am J Neuroradiol1987，8，： | 1 |
| 12 | Whouses nutritional labeling,and what effects does label usehave on diet quality显示文摘 | GUTHRIE J F FOX J J CLEVELAND L E | 1995 | J N Edu1995，27，4： | 1 |
| 13 | Ferro-electrically induced ferromagnetism 显示文摘 | Fox D L Scott J F | 1977 | Journal of Physics C-Solid State Physics1977，，10： | 1 |
| 14 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 15 | Incremental clustering for very large document databases: Initial MARIAN experience显示文摘 | CAN F FOX E A SNAVELY C D | 1995 | Information sciences1995，84，12： | 1 |
| 16 | Influence of starters on chemical, biochemical,and sensory changes in Turkish White-Brined Cheese during ripening显示文摘 | Hayalogu A A Guven M Fox P F | 2005 | Journal of Dairy Science2005，，10： | 1 |
| 17 | Smartest review of micro-simulation models显示文摘 | ALGERS S BERNAUER E BOERO M BREHERET L DI- TARANTO C DOUGHERTY M FOX K GABARD J F | 1997 | Transport RTD1997，，3： | 1 |
| 18 | Purification and characterization of Paecilomyces lilacinus dextranase显示文摘 | Lee J M Fox P F | 1985 | Enzyme and Microbial Technology1985，7，11： | 1 |
| 19 | Dairy chemistry and biochemistry 显示文摘 | FOX P F MCSWEENEY P L H | 1998 | Blackie Academic Professi-onal1998，，： | 1 |
| 20 | Use of detachable balloons for proximal artery occlusion in the treatment of unclippable cerebral aneurysms显示文摘 | Fox A J Vinuela F Pelz D M | 1987 | J Neurosurg1987，66，1： | 1 |
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