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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Empirical Extended-Range Prediction of the Madden-Julian Oscillation显示文摘 | LO Fiona HENDON Harry H | 2000 | Mon Wea Rev2000，128，8： | 1 |
| 3 | A study of MDL improvement for the in vivo measurement of lead in bone 显示文摘 | Nie H Fiona M Joanne O | 2004 | Nucl Instru & Metho in Phys Resear B2004，213，： | 1 |
| 4 | PCR - based gene synthesis as an efficient approach for expression of the A + T - rich malaria genome 显示文摘 | Chrislaine W M Elisabeth P C Fiona H | 1999 | Protein Engineering1999，12，12： | 1 |
| 5 | Skp2 gene copy number aberrations are common in non-small cell lung carcinoma,and its overexpression in tumors with ras mutation is a poor prognos tic marker显示文摘 | ZHU C Q FIONA H BLACKHALL M P | 2004 | Clin Cancer Res2004，10，6： | 1 |
| 6 | Social anxiety and coping strategies in the eating disorders显示文摘 | Hendrik H Fiona W Caroline M | 2003 | Eating Behaviors2003，4，： | 1 |
| 7 | IS/IT Outsourcing Practices of Small and Medium-Sized Manufacturers显示文摘 | Fiona H Rohde | 2004 | International Journal of Accounting Information Systems2004，5，4： | 1 |
| 8 | Social anxiety and coping strategies in the eating isorders显示文摘 | Hendrik H Fiona W Glenn W | 2003 | Eating Behav- iors2003，4，2： | 1 |
| 9 | Mycoplasmapneumoniae infection in a podiatric population: Analysis of soluble immune markers as risk factors for asthma显示文摘 | Jaythoon H Fiona I Soamus D | 2008 | Hum Immunol2008，69，12： | 1 |
| 10 | separation of human lepidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression 显示文摘 | Fiona M Watt | 1993 | cell1993，73，： | 1 |
| 11 | Social anxiety and coping strategies in the eating disorders显示文摘 | HENDRIK H FIONA W CAROLINE M | 2003 | Eating Behav2003，4，： | 1 |
| 12 | Oocyte-granulosa cell interactions during mouse follicular development: regulation of kit ligand expression and its role in oocyte growth 显示文摘 | Fiona H Thomas Barbara C Vanderhyden | 2006 | Reproductive Biology and Endocrinology2006，4，： | 1 |
| 13 | Luminex technology for HLA antibody detection in organ transplantation显示文摘 | Brian DT Fiona H Lind C | 2009 | Nephrology2009，14，2： | 1 |
| 14 | First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial显示文摘 | Gareth J Morgan Faith E Davies Walter M Gregory Kim Cocks Sue E Bell Alex J Szubert Nuria Navarro-Coy Mark T Drayson Roger G Owen Sylvia Feyler A John Ashcroft Fiona Ross Jennifer Byrne Huw Roddie Claudius Rudin Gordon Cook Graham H Jackson J Anthony Chil | 2010 | The Lancet . 2010 (9757)2010，，： | 1 |
| 15 | Characterisation of host defence protein in milk using a proteomic approach显示文摘 | GRANT S STEPHEN H FIONA Y S | 2007 | J Proteome Res2007，6，： | 1 |
| 16 | Application of tris(hydroxymethyl) phosphine as a coupling agent for alcohol dehydrogenase immobilization 显示文摘 | Fiona C Cochrane Helen H Petach William Henderson | 1996 | Enzyme and Microbial Technology1996，18，： | 1 |
| 17 | Global map of growth-regulated gene expression in burkholderia pseudomallei,the causative agent of melioidosis显示文摘 | Fiona R Mitali S T Sarah V H | 2006 | J Bacteriol2006，188，23： | 1 |
| 18 | Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance 显示文摘 | H Raza ASarah-Jane D Fiona MB | 2011 | Breast Cancer Research2011，13，6： | 1 |
| 19 | Social anxiety and coping strategies in the eating disorders显示文摘 | Hendrik H Fiona W Caroline M | 2003 | Eating Behaviors2003，4，： | 1 |
| 20 | Determination of the levels of dioxin and dioxin-like compounds in the Australian population by analysis of pooled human breast milk显示文摘 | Fiona H Jochen FM Lee LM | 2004 | Organohalgen Compounds2004，66，： | 1 |
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