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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | Pharmacologic approaches to treatment resistant depression:Evidences and personal experience显示文摘AIM: To review evidence supporting pharmacological treatments for treatment-resistant depression(TRD) and to discuss them according to personal clinical experience.METHODS: Original studies, clinical trials, systematic reviews, and meta-analyses addressing pharmacological treatment for TRD in adult patients published from 1990 to 2013 were identified by data base queries(Pub Med, Google Scholar e Quertle Searches) using terms: 'treatment resistant depression', 'treatment refractory depression', 'partial response depression', 'non responder depression', 'optimization strategy', 'switching strategy', 'combination strategy', 'augmentation strategy', selective serotonin reuptake inhibitors antidepressants(SSRI), tricyclic antidepressants(TCA), serotonin norepinephrine reuptake inhibitors antidepressants, mirtazapine, mianserine, bupropione, monoamine oxidase inhibitor antidepressant(MAOI), lithium, thyroid hormones, second generation antipsychotics(SGA), dopamine agonists, lamotrigine, psychostimulants, dextromethorphan, dextrorphan, ketamine, omega-3 fatty acids, S-adenosil-L-metionine, methylfolat, pindolol, sex steroids, glucocorticoid agents. Other citations of interest were further identified from references reported in the accessed articles. Selected publications were grouped by treatment strategy:(1) switching from an ineffective antidepressant(AD) to a new AD from a similar or different class;(2) combining the current AD regimen with a second AD from a different class; and(3) augmenting the current AD regimen with a second agent not thought to be an antidepressant itself.RESULTS: Switching from a TCA to another TCA provides only a modest advantage(response rate 9%-27%), while switching from a SSRI to another SSRI is more advantageous(response rate up to 75%). Evidence supports the usefulness of switching from SSRI to venlafaxine(5 positive trials out 6), TCA(2 positive trials out 3), and MAOI(2 positive trials out 2) but not from SSRI to bupropione, duloxetine and mirtazapine. Three reviews demonstrated that the benefits of intraand cross-class switch do not significantly differ. Data on combination strategy are controversial regarding TCA-SSRI combination(positive results in old studies, negative in more recent study) and bupropion-SSRI combination(three open series studies but not three controlled trails support the useful of this combination) and positive regard mirtazapine(or its analogue mianserine) combination with ADs of different classes. As regards the augmentation strategy, available evidences supported the efficacy of TCA augmentation with lithium salts and thyroid hormone(T3), but are conflicting regard the SSRI augmentation with these two drugs(1 positive trial out of 4 for lithium and 3 out of 5 for thyroid hormone). Double-blind controlled studies showed the efficacy of AD augmentation with aripiprazole(5 positive trials out 5), quetiapine(3 positive trials out 3) and, at less extent, of fluoxetine augmentation with olanzapine(3 positive trials out 6), so these drugs received the FDA indication for the acute treatment of TRD. Results on AD augmentation with risperidone are conflicting(2 short term positive trials, 1 short-term and 1 long-term negative trials). Case series and open-label trials showed that AD augmentation with pramipexole or ropinirole, two dopamine agonists, could be an effective treatment for TRD(response rate to pramipexole 48%-74%, to ropinirole 40%-44%) although one recent double-blind placebo-controlled study does not support the superiority of pramipexole over placebo. Evidences do not justify the use of psychostimulants, omega-3 fatty acids, S-adenosil-Lmetionine, methylfolate, pindolol, lamotrigine, and sex hormone as AD augmentation for TRD. Combining the available evidences with our experience we suggest treating non-responders to one SSRI bupropion or mirtazapine trial by switching to venlafaxine, and nonresponders to one venlafaxine trial by switching to a TCA or, if TCA are not tolerated, combining mirtazapine with SSRI or venlafaxine. In non-responders to two or more ADs(including at least one TCA if tolerated) current AD regimen could be augmented with lithium salts(mainly in patients with bipolar depression or suicidality), SGAs(mostly aripiprazole) or DA-agonists(mostly pramipexole). In patients with severe TRD, i.e., non-responders to combination and augmentation strategies as well as to electroconvulsive therapy if workable, we suggest to try a combination plus augmentation strategy.CONCLUSION: Our study identifies alternative effective treatment strategies for TRD. Further studies are needed to compare the efficacy of different strategies in more homogeneous subpopulations. | Antonio Tundo Rocco de Filippis Luca Proietti | 2015 | World Journal of Psychiatry2015，5，3： | 15 |
| 3 | Erectile dysfunction and central obesity: an Italian perspective显示文摘可勃起的机能障碍(编辑) 是肥胖的经常的复杂并发症。这评论的目的是极其分析肥胖和编辑的框架,把在二个病理学的实体之间的连接。当前的临床的证据显示出那肥胖,和特别地中央的肥胖,与两个 arteriogenic 版本被联系并且减少了睾丸激素(T) 层次。联系肥胖的性腺机能减退和增加的心血管的风险可能部分在超重、肥胖的个人认为编辑的更高的流行正当,是想得到的。相反地,与肥胖有关的心理骚乱不似乎然而在肥胖相关的编辑的致病起一个主要作用,在编辑之间的协会和内脏的胖累积从已知的联系肥胖的 comorbidities 是独立的临床、现出症状之前的潜的数据表演。因此,内脏的脂肪怎么能损害阴茎 microcirculation,仍然保持未知。自从在编辑题目的中央肥胖在高心血管的风险分类个人,这个点是特别地相关的,特别在最年轻的。在肥胖的题目的编辑的存在可能在说服他们开始一个善良的周期帮助保健专业人员,在性机能障碍的修正将是为改进生活方式行为的报酬的地方。Unsatisfying 性活动为请教接着,应该利用机会鼓励肥胖的病人对待的保健专业版代表有意义的、直接动机,除编辑以外,内在的相反的条件,这样不仅恢复可勃起的功能,而且全面健康。 | Giovanni Corona Giulia Rastrelli Sandra Filippi Linda Vignozzi Edoardo Mannucci Mario Maggi | 2014 | Asian Journal of Andrology2014，16，4： | 9 |
| 4 | Harness the power of endogenous neural stem cells by biomaterials to treat spinal cord injury显示文摘Spinal cord injury(SCI)is a devastating medical condition without a cure.Reestablishment of neuronal connections after spinal cord injury is the'holy grail'of SCI research.However,grafting exogenous cells,including neural stem cells and a variety of adult somatic cells,has had very limited success[1].Two back-to-back papers published in | DE FILIPPIS Lidia SüDHOF Thomas C. PANG ZhiPing P. | 2015 | Science China(Life Sciences)2015，58，11： | 4 |
| 5 | Influence of shoulder geometry on microstructure and mechanical properties of friction stir welded 6082 aluminium alloy显示文摘 | A. Scialpi L.A.C. De Filippis P. Cavaliere | 2006 | Materials and Design2006，，4： | 2 |
| 6 | Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial显示文摘 | David Laharie Arnaud Bourreille Julien Branche Matthieu Allez Yoram Bouhnik Jerome Filippi Frank Zerbib Guillaume Savoye Maria Nachury Jacques Moreau Jean-Charles Delchier Jacques Cosnes Elena Ricart Olivier Dewit Antonio Lopez-Sanroman Jean-Louis Dupas F | 2012 | The Lancet2012，，9857： | 2 |
| 7 | Energy retrofit and conservation of a historic building using multi-objective optimization and an analytic hierarchy process显示文摘When deciding on the best historic building retrofit,energy savings and thermal comfort can be quantitatively evaluated using an energy model,whereas conservation compatibility is intrinsically qualitative and reflects the perspective of the local heritage authority. We present a methodology that permits finding and comparing optimal retrofits for historic buildings in a multi-perspective and quantitative way. We use an analytic hierarchyprocess to quantify conservation compatibility by distilling a conservation score from the opinions of 10 experts in the field. This score,along with energy needs for heating and cooling and thermal comfort,are the three targets of a multi-objective optimization aimed at identifying optimal retrofits for a medieval building in the north of Italy,destined to become a museum. Retrofit measures considered were different kinds of external and internal envelope insulation,improvement of airtightness,replacement of windows,and ventilative cooling. The result is a portfolio of optimal retrofits that cover the whole range of conservation compatibility. We showthat in the analyzed case heritage preservation is compatible with a four-fold reduction in energy needs at a high thermal comfort level. Even higher energy savings are only achievable at the cost of heritage degradation. | Francesca Roberti Ulrich Filippi Oberegger Elena Lucchi Alexandra Troi 侯恩哲 | 2017 | 建筑节能2017，45，3： | 2 |
| 8 | Prospective randomized comparison between axial- and lateral-viewing capsule endoscopy systems in patients with obscure digestive bleeding显示文摘 | Mathieu Pioche Geoffroy Vanbervliet Philippe Jacob Cloti de Duburque Rodica Gincul Bernard Filoche Jacques Daudet Jér?me Filippi Jean-Christophe Saurin | 2013 | Endoscopy2013，，： | 2 |
| 9 | 基于长时序Landsat影像的东湖水体悬浮物浓度分析显示文摘利用1973-2018年共48景Landsat卫星影像,基于同期Landsat影像建立了东湖悬浮物(total suspended solids, TSS)反演模型,分析得到了东湖TSS的长时序变化趋势.结果显示,在1973-1998年间,东湖TSS浓度先上升,在1998年前后达到最高值,而后缓慢下降,自2010年起趋于稳定.这说明武汉市的湖泊保护与治理措施发挥了显著的作用.研究还发现,相比雨季数据,旱季数据反演结果波动性较小. | 卢东烁 李建 A Filippi | 2019 | 武汉大学学报(工学版)2019，52，10： | 2 |
| 10 | Hormetic effect(s) of tetracyclines as environmental contaminant on Zea mays显示文摘 | Luciana Migliore Feliciana Godeas Stefania Paola De Filippis Paolo Mantovi Davide Barchi Cecilia Testa Nicolino Rubattu Gianfranco Brambilla | 2009 | Environmental Pollution2009，，1： | 2 |
| 11 | Humans identify negative (but not positive) arousal in silver fox vocalizations: implications for the adaptive value of interspecific eavesdropping显示文摘 | Piera FILIPPI Svetlana S. GOGOLEVA Elena V. VOLODINA Ilya A. VOLODIN Bart de BOER | 2017 | Current Zoology2017，63，4： | 2 |
| 12 | Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis显示文摘 | Barkhof F Filippi M Miller DH | 1997 | Brain1997，120，11： | 1 |
| 13 | 显示文摘 | Filippi M Martinelli V | 1994 | J Neurol Sci1994，125，： | 1 |
| 14 | Distinct delta and jagged genes control sequential segregation of pancreatic cell types fromprecursor pools in zebrafish显示文摘 | ZECCHIN E FILIPPI A BIEMAR F | 2007 | Dev Biol2007，301，： | 1 |
| 15 | Thermal comfort in Italian classrooms under free running conditions during mid seasons:Assessment through objective and subjective approaches显示文摘 | STEFANO PAOLO CORGNATI ROBERTA ANSALDI MARCO FILIPPI | 2009 | Building and Environment2009，44，4： | 1 |
| 16 | The adiponectin gene SNP + 276 G > T associates with early-onset coronary artery disease and withlower levels of adiponectin in younger coro- nary artery disease patients(age < or = 50 years)显示文摘 | Filippi E Sentinelli F Romeo S | 2005 | J Mol Med2005，83，9： | 1 |
| 17 | Periodontal healing after intentional auto--alloplastic reimplantation of injured immature upper front teeth 显示文摘 | Pohl Y Filippi A Tekin U | 2000 | J Clin Periodontol2000，27，3： | 1 |
| 18 | The contribution of voxel-based morphometry in staging patients with mild cognitive im- pairment显示文摘 | Bozzali M Filippi M Magnani G | 2006 | Neurology2006，67，： | 1 |
| 19 | Diffusion changes in the aging human brain显示文摘 | Chun T Filippi CG Zimmerman RD | 2000 | AJNR2000，21，： | 1 |
| 20 | Sulphur-extended asphalt: reaction kinetics of H2S evolution显示文摘 | de Filippis Giavarini C Santarelli M L | 1998 | Fuel1998，77，5： | 1 |
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