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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 3 | Colometer:A real-time quality feedback system for screening colonoscopy显示文摘AIM:To investigate the performance of a new software-based colonoscopy quality assessment system.METHODS:The software-based system employs a novel image processing algorithm which detects the levels of image clarity,withdrawal velocity,and level of the bowel preparation in a real-time fashion from live video signal.Threshold levels of image blurriness and the withdrawal velocity below which the visualization could be considered adequate have initially been determined arbitrarily by review of sample colonoscopy videos by two experienced endoscopists.Subsequently,an overall colonoscopy quality rating was computed based on the percentage of the withdrawal time with adequate visualization(scored 1-5;1,when the percentage was 1%-20%;2,when the percentage was 21%-40%,etc.).In order to test the proposed velocity and blurriness thresholds,screening colonoscopy withdrawal videos from a specialized ambulatory colon cancer screening center were collected,automatically processed and rated.Quality ratings on the withdrawal were compared to the insertion in the same patients.Then,3 experienced endoscopists reviewed the collected videos in a blinded fashion and rated the overall quality of each withdrawal(scored 1-5;1,poor;3,average;5,excellent) based on 3 major aspects:image quality,colon preparation,and withdrawal velocity.The automated quality ratings were compared to the averaged endoscopist quality ratings using Spearman correlation coefficient.RESULTS:Fourteen screening colonoscopies were assessed.Adenomatous polyps were detected in 4/14(29%) of the collected colonoscopy video samples.As a proof of concept,the Colometer software rated colonoscope withdrawal as having better visualization than the insertion in the 10 videos which did not have any polyps(average percent time with adequate visualization:79% ± 5% for withdrawal and 50% ± 14% for insertion,P < 0.01).Withdrawal times during which no polyps were removed ranged from 4-12 min.The median quality rating from the automated system and the reviewers was 3.45 [interquartile range(IQR),3.1-3.68] and 3.00(IQR,2.33-3.67) respectively for all colonoscopy video samples.The automated rating revealed a strong correlation with the reviewer's rating(ρ coefficient= 0.65,P = 0.01).There was good correlation of the automated overall quality rating and the mean endoscopist withdrawal speed rating(Spearman r coefficient= 0.59,P = 0.03).There was no correlation of automated overall quality rating with mean endoscopists image quality rating(Spearman r coefficient= 0.41,P = 0.15).CONCLUSION:The results from a novel automated real-time colonoscopy quality feedback system strongly agreed with the endoscopists' quality assessments.Further study is required to validate this approach. | Dobromir Filip Xuexin Gao Leticia Angulo-Rodriguez Martin P Mintchev Shane M Devlin Alaa Rostom Wayne Rosen Christopher N Andrews | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 4 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 5 | Increased production of collagen in vivo by hepatocytes and nonparenchymal cells in rat with carbon tetrachloride-induced hepatic fibrosis显示文摘 | CHOJKIER M LYCHE KD FILIP M | 1988 | Hepatology1988，8，8： | 2 |
| 6 | Characterization of the denitrifying fraction of phosphate accumulating organisms in biological phosphate removal显示文摘 | Meinhold J Filipe C D M Daigger G T | 1999 | War Sci Technol1999，39，1： | 1 |
| 7 | Resveratrol and its antioxidant and antimicrobial effectiveness 显示文摘 | FILIP V PLOCKOVA M SMIDRKAL J | 2003 | Food Chem2003，83，4： | 1 |
| 8 | Resveratrol and its antioxidant and antimicrobial effectiveness显示文摘 | Filip V Plockova M Smidrkal J | 2003 | Food Chem2003，83，： | 1 |
| 9 | Cadmium inhibits of UV-,methylmethane-sulfonate and N-muthyl-N-nitrosourea-induced DNA damage in Chinese hamster ovary cells显示文摘 | Fatur T Lab T T Filipic M | 2003 | Mutat Ras2003，529，12： | 1 |
| 10 | Postcholecystectomy syndrome an algorithmic approach显示文摘 | Filip M Saftoiu A Popescu C | 2009 | Gastrointestin Liver Dis2009，18，1： | 1 |
| 11 | Cationic liposomes for gene delivery显示文摘 | Simaes S Filipe A Faneca H Mano M Penacho N Dtizgiines N | 2005 | Expert Opin Drug Deliv2005，2，： | 1 |
| 12 | Microcystin-LR induced DNA damage in human peripheral blood lymphocytes显示文摘 | Zegura B Gajski G Straser A Garaj-Vrhovac V Filipic?M | 2011 | Mutat Res2011，726，2： | 1 |
| 13 | Polyethylene wear debris and long-term clinical failure of the Charite disc prosthesis: A study of 4 patients 显示文摘 | Andre V O Steven M Filip S | 2007 | Spine2007，32，2： | 1 |
| 14 | Characterization of the denitrifying fraction of phosphate accumulating organisms in biological phosphate removal显示文摘 | Meinhold J Filipe C D M Daigger G T | 1999 | Water Science and Technology1999，39，1： | 1 |
| 15 | Effect of shear rate on aggregate size and structure in the process of aggregation and at steady state显示文摘 | Bubakova P Pivokonsky M Filip P | 2013 | Powder Technology2013，235，： | 1 |
| 16 | Postcholecystectomy syndromes-an algorithmic approach 显示文摘 | Filip M Saftoiu A Popescu C | 2009 | J Gastrointestin Liver Dis2009，18，1： | 1 |
| 17 | Effects of serotonin (5 -HT) (1B) receptor ligands on cocaine-seeking behavior in rats 显示文摘 | Przeglinski E Golda A Filip M | 2008 | Phannacol Rep2008，60，6： | 1 |
| 18 | Behavioral evidence for the significance of serotoninergic (5 - HT) receptors in cocaine addiction显示文摘 | Filip M Alenina N Bader M | 2010 | Addict Biol2010，15，3： | 1 |
| 19 | Remote sensing of global wetland dynamics with multiple satellite data sets显示文摘 | Catherine P Elaine M Filipe A | 2001 | Geophysical Researeh Letters2001，28，15： | 1 |
| 20 | Cylindrospermopsin induced transcriptional responses in human hepatoma Hep G2 cells显示文摘 | Straser A Filipic?M Zegura B | 2013 | Toxicol In Vitro2013，27，6： | 1 |
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