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| 1 | Tumor necrosis factor-α-G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients显示文摘AIM To investigate the association of tumor necrosis factor alpha(TNFα)-G308 A polymorphism with different liver pathological changes in treatment-na?ve Egyptian patients infected with hepatitis C virus(HCV) genotype 4.METHODS This study included 180 subjects,composed of 120 treatment-na?ve chronic HCV patients with different fibrosis grades(F0-F4) and 60 healthy controls. The TNFα-G308 A region was amplified by PCR and the different genotypes were detected by restriction fragment length polymorphism analysis. The TNFα protein was detected by enzyme-linked immunosorbent assay. The influence of different TNFα-G308 A genotypes on TNFα expression and liver disease progression were statistically analyzed. The OR and 95%CI were calculated to assess the relative risk confidence.RESULTS Current data showed that the TNFα-G308 A SNP frequency was significantly different between controls and HCV infected patients(P = 0.001). Both the AA genotype and A allele were significantly higher in late fibrosis patients(F2-F4,n = 60) than in early fibrosis patients(F0-F1,n = 60)(P = 0.05,0.04 respectively). Moreover,the GA or AA genotypes increased the TNFα serum level greater than the GG genotype(P = 0.002). The results showed a clear association between severe liver pathological conditions(inflammation,steatosis and fibrosis) and(GA + AA) genotypes(P = 0.035,0.03,0.04 respectively). The stepwise logistic regression analysis showed that the TNFα genotypes(GA + AA) were significantly associated with liver inflammation(OR = 3.776,95%CI: 1.399-10.194,P = 0.009),severe steatosis(OR = 4.49,95%CI: 1.441-14.0,P = 0.010) and fibrosis progression(OR = 2.84,95%CI: 1.080-7.472,P = 0.034). Also,the A allele was an independent risk factor for liver inflammation(P = 0.003),steatosis(P = 0.003) and fibrosis(P = 0.014). CONCLUSION TNFα SNP at nucleotide-308 represents an important genetic marker that can be used for the prognosis of different liver pathological changes in HCV infected | Noha G Bader El Din Sally Farouk Reem El-Shenawy Marwa K Ibrahim Reham M Dawood Mostafa M Elhady Ahmed M Salem Naglaa Zayed Ahmed Khairy Mostafa K El Awady | 2016 | World Journal of Gastroenterology2016，22，34： | 3 |
| 2 | HepG2 cells support viral replication and gene expression of hepatitis C virus genotype 4 in vitro显示文摘瞄准:与丙肝的长期的复制建立一个房间文化系统病毒(HCV ) 染色体和病毒的抗原的表示在试管内。方法:HepG2 房间线被孵化与长期的丙肝从一个病人与浆液为它的危险性测试到 HCV。房间和上层清液在文化期间在各种各样的时间点被收获。文化上层清液为它感染天真的房间的能力被测试。存在减(反感觉) 在房间的核心和 E1 抗原的 RNA 海滨,和察觉被 RT-PCR 和免疫学的技术(流动血细胞计数和西方的污点) 分别地检验。结果:细胞内部的 HCV RNA 首先在 d 上被检测 3 在感染以后然后能一致地在至少三个月的一个时期上在房间和上层清液被检测。新鲜房间能从有教养的感染的房间感染上层清液。流动 cytometric 分析证明表面和在房子里使用的细胞内部的 HCV 抗原表示使 polyclonal 成为了抗体(反核心,和 anti-E1 ) 。西方的污点分析证明在分子量的产生免疫性的肽的簇的表示在一个月内在 31 和 45 kDa 之间延长了感染的房间的旧文化而这簇在 uninfected HepG2 房间是无法发现的。结论:HepG2 房间线产生 HCV 感染而且支持它的复制在试管内不仅。HCV 结构的蛋白质的表示能在感染的 HepG2 房间被检测。这些房间也能够流病毒的粒子进接着对 uninfected 房间变得传染的培养基。 | Mostafa K El-Awady Ashraf A Tabll Yasmine S El-Abd Mahmoud M Bahgat Hussein A Shoeb Samar S Youssef Noha G Bader El Din El-Rashdy M Redwan Maha El-Demellawy Moataza H Omran Wael T El-Garf Said A Goueli | 2006 | World Journal of Gastroenterology2006，12，30： | 2 |
| 3 | Fluvastatin inhibits hepatitis C replication in humans 显示文摘 | Bader T Fazili J Madhoun M | 2008 | Am J Gastroenterol2008，103，6： | 1 |
| 4 | Update on tissue renin-angiotensin systems 显示文摘 | Bader M Ganten D | 2008 | Mol Med2008，86，6： | 1 |
| 5 | Prevalence and correlates of insomnia in the Swedish population aged 19-75 years 显示文摘 | Ohayon M M Bader G | 2010 | Sleep Med2010，11，10： | 1 |
| 6 | Recur- rence of biliary disease following non - operative manage- ment in elderly patients 显示文摘 | BERGMAN S AL -BADER M SOURIAL N | 2015 | Surg Endosc2015，29，12： | 1 |
| 7 | 'Optimal' Portfolios Relative to Benchmark Allocations显示文摘 | Bader L N Kogelman S | 1993 | Journal of Portfolio Management1993，19，4： | 1 |
| 8 | A predictive instrument for coronary artery aneurysms in Kawasaki disease显示文摘 | Beiser AS Takahashi M Bader AL | 1998 | Am J Cardiol1998，81，9： | 1 |
| 9 | Tongue protrusion and feeding dystonia: a hallmark of chorea-acanthocytosis显示文摘 | Bader B Walker R H Vogel M | 2010 | Mov Disord2010，25，1： | 1 |
| 10 | Blood pressure response to chronic episodic hypoxia: the renin-angiotensin system显示文摘 | Fletcher EC Orolinova N Bader M | 2002 | J Ap- pl Physiol ( 1985)2002，92，： | 1 |
| 11 | A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells显示文摘 | Bader SA Walker M Harrison DJ | 2007 | Br J Cancer2007，96，4： | 1 |
| 12 | The Poly- scope: a modular design, semidisposable flexible uret- erorenoscope sysem显示文摘 | Bader M J Gratzke C Wahher S | 2010 | J Endourol2010，24，7： | 1 |
| 13 | Initial German experience with transapical implantation of a second-generation transcatheter heart valve for the treatment of aortic regurgitation 显示文摘 | Seiffert M Bader R Kappert U | 2014 | JACC Cardiovasc Interv2014，7，10： | 1 |
| 14 | Benchmark Departures and Total Fund Risk: A Second Dimension of Diversification显示文摘 | Bader L N Kogelman S | 1995 | Financial Analysts Journal1995，51，5： | 1 |
| 15 | Ablation dynamics of periodic nanostructures for polymer-based all-optical devices 显示文摘 | Klein-Wiele J H Bader M A Bauer I | 2002 | Synthetic Metals2002，127，： | 1 |
| 16 | Integrated processing equipment显示文摘 | Bader M E Hall R P Strasser G | 1990 | Solid State Technology1990，33，5： | 1 |
| 17 | Contemporary man- agement of ureteral stones 显示文摘 | Bader M J Eisner B Porpiglia F | 2012 | Eur Urol2012，61，4： | 1 |
| 18 | Driver behavior du- ring flashing green before amber: a comparative study 显示文摘 | Koll H Bader M Axhuasen K W | 2004 | Accident Analysis and Prevention2004，36，： | 1 |
| 19 | Laser therapy for upper urinary tract transitionall cell carcinoma: indications and management显示文摘 | BADER M J SROKA R GRATZKE C | 2009 | Eur Urol2009，56，1： | 1 |
| 20 | Characteristics of flight nursing practice显示文摘 | Bader GB Terhorst M Heilman P | 1995 | Air Med J1995，14，4： | 1 |
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