|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neural stem cell markers,nestin and musashi proteins,in the progression of human glioma:correlation of nestin with prognosis of patient survival显示文摘 | Strojnik T R■sland GV Sakariassen PO Kavalat R Lab T | 2007 | 中国神经肿瘤杂志2007，5，3： | 34 |
| 2 | Cadmium inhibits of UV-,methylmethane-sulfonate and N-muthyl-N-nitrosourea-induced DNA damage in Chinese hamster ovary cells显示文摘 | Fatur T Lab T T Filipic M | 2003 | Mutat Ras2003，529，12： | 1 |
| 3 | Pla sm a fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality:an individual participant Meta-analysis显示文摘 | Col lab or at ion FS Da ne sh J L ew i ng t on S | 2005 | JAMA2005，294，14： | 1 |
| 4 | Beckwith - Wiedemann syndrome and assisted reproduction technology (ART) 显示文摘 | E R Maher LAB S C Bowdin A Luharia W Cooper T R Cole F Macdonald | 2003 | J Med Genet2003，40，： | 1 |
| 5 | Hybrid scanning ion conductance and scanning near-field optical microscopy for the study of living cells显示文摘 | KORCHEV YE RAVAL M LAB MJ GORELIK J EDWARDS CR RAYMENT T Kenerman D | 2000 | Biophys J2000，78，5： | 1 |
| 6 | The Inflamma- some-mediated caspase-1 activation controls adipocyte differ- entiation and insulin sensitivity 显示文摘 | Stienstra R Joosten LAB Koenen T | 2010 | Cell Metab2010，12，： | 1 |
| 7 | The role of reactive oxygen species in microcystin-LR-induced DNA damage显示文摘 | Zegura B Lab T T Filipic M | 2004 | Toxicology2004，200，： | 1 |
| 8 | Memory for the past after temporal lobectomy:impact of epilepsy and cognitive variables显示文摘 | Lab S Grayson S Lee T | 2004 | Neuropsychologia2004，42，12： | 1 |
| 9 | Effects of abrupt changes in ventricular loading on repolarization induced by transient aortic occlusion in humans显示文摘 | Taggart P Sutton P Lab M Runnalls M O′Brien W Treasure T | 1992 | Am J Physiol1992，263，32： | 1 |
| 10 | Cadmium inhibits of UV, methylmethane- sulfonate and N - muthyl - N - nitrosourea induced DNA damage in Chinese hamster ovary cells显示文摘 | Fatur T Lab T T Filipic M | 2003 | Murat Res2003，529，12： | 1 |
| 11 | Fourier volume rendering显示文摘 | Malzbender T Labs H P | 1993 | ACM Transactions on Graphics1993，12，3： | 1 |
| 12 | Cost-Effective Machining of Granite by Reducing Tribological Interactions显示文摘In order to implement cost-effective machining of gr anite materials with diamond impregnated tools, we should realize low tool w ear, low energy consumption, and high cutting efficiency, while the accuracy of the workpiece surfaces are maintained to be satisfactory. It is understood that the main factors affecting the tool wear, the energy, and the efficiency during the machining process are related to the tribological interactions that occur at the interface between the diamond tool surface and the workpiece. Based on this consideration, we propose a new machining method to machine granite materia ls to achieve improved cost effectiveness. In the proposed method, the tribologi cal interactions are maintained to a minimum. Based on the analyses of the experimental results, the following conclusions can be drawn: The wear performance is greatly dependent on the machining parameters and their combination. Therefore, optimum machining parameters must be set up at first in order to optimize the tribological characteristics of segments and thereby sawbl ade performance. These may be realized by balancing the energy expended by frict ion and the mechanical load on diamond crystal. The geometry and structure of diamond segments are another important criterion f or the diamond saw blade. Using a seven-layer structure for multi-blades sawin g and applying segments with side slots for trimming application had greatly red uced the frictions in the sawing processes. The wetting and bonding between diamonds and matrix alloys have been considered as the prerequisite for high wear performance of the segments. Diamonds coated w ith Ti-Cr alloy by a unique technique can effectively improve its wetting c apability and provide more storage space for debris, thereby reducing friction i nteractions. | LI Yuan 1, HUANG Hui 1, SHEN Jian-yun 1, XU Xi-peng 1, GAO Yong-sheng 2 (1. Province Key Lab of Stone Machining, Huaqiao University, Quanzhou 362011, China 2. Department of Mechanical Engineering, Hong Kong University of Science and T echnology, Hong Kong, China) | 2002 | 厦门大学学报(自然科学版)2002，41，S1： | 1 |
| 13 | Effect of geometry on the effective moisture transfer diffusion coefficient 显示文摘 | TUTUNCU M A LAB UZA T P | 1996 | J Food Eng1996，30，34： | 1 |
| 14 | A tutorial on hidden Markov models and selected applications in speech recognition显示文摘 | Rabiner L R AT&T Bell Lab Murray Hill | 1989 | Proceedings of the IEEE1989，77，2： | 1 |
| 15 | Tissue inhibitor of metalloproteinase-1 protects MCF-7 breast cancer cells from paclitaxel-induced apoptosis by decreasing the stability of cyclin B1显示文摘Paclitaxel(PTX) is a very effective drug in treating tumors.It disturbs microtubule dynamics and impairs the transition of cells from metaphase to anaphase in mitosis,leading to cell death by apoptosis.However,the effectiveness of PTX in cancer chemotherapy is hampered by drug resistance in some patients.Tissue inhibitor of metalloproteinase-1(TIMP-1) is well known to be capable of inhibiting apoptosis.Elevated tumor tissue TIMP-1 levels have been significantly associated with a poor response to chemotherapy.We hypothesized that TIMP-1 could reduce the sensitivity of breast cancer cells to PTX by inhibiting apoptosis.To test this hypothesis,we first examined the effects of TIMP-1 on the apoptosis induced by PTX and investigated the effects of TIMP-1 on the expression and stability of cyclin B1 that critically regulates the metaphase to anaphase transition during mitosis in MCF-7 breast cancer cells.Our data demonstrate that TIMP-1 could significantly decrease the sensitivity of MCF-7 cells to PTX-induced apoptosis,attenuate mitotic blockage in G(2) /M,and enhance the degradation of cyclin B1.To further investigate whether the inhibitory effect of TIMP-1 on PTX-induced apoptosis is mediated by lowering levels of cyclin B1,a cyclin B1-expression plasmid was transfected into clone overexpressing TIMP-1.The levels of PTX-induced apoptosis were then analyzed.The data showed that the TIMP-1-based decrease in PTX-induced apoptosis was reversed by cyclin B1.Our data indicate that TIMP-1 can protect breast cancer cells from PTX-induced apoptosis by decreasing the stability of cyclin B1. | Wang,T Lv,JH Zhang,XF Li,CJ Han,X Sun,YJ Nanjing Med Univ,Key Lab Human Funct Genom Jiangsu Prov,Nanjing 210029,Peoples R China Nanjing Med Univ,Dept Cell Biol & Med Genet,Nanjing 210029,Peoples R China Nanjing Univ,Sch Med,Nanjing 210008,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing 210029,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 1 |
| 16 | In Vivo Antimicrobial Activity of 2% Chlorhexidine Used as a Root Canal Irrigating Solution 显示文摘 | Leonardo M R Filho M T Silva LAB | 1999 | Journal of Endodontics1999，25，3： | 1 |
| 17 | Cadmium inhibits of UV-,methylmethanesulfonate and N-muthyl-N-nitrosourea-induced DNA damage in Chinese hamster ovary cells显示文摘 | Fatur T Lab TT Filipic M | 2003 | Mutat Ras2003，529，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员