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| 1 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 2 | Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer显示文摘AIM:To clarify the value of combined use of markers for the diagnosis of gallbladder cancer and prediction of its prognosis.METHODS:Serum cancer antigens(CA)199,CA242,carcinoembryonic antigen(CEA),and CA125 levels were measured in 78 patients with gallbladder cancer(GBC),78 patients with benign gallbladder diseases,and 78 healthy controls using electrochemiluminescence.CA199,CA242,CEA,and CA125 levels and positive rates were analyzed and evaluated pre-and postoperatively.Receiver operator characteristic curves were used to determine diagnostic sensitivity and specificity of GBC.Survival time analysis,including survival curves,and multivariate survival analysis of a Cox proportional hazards model was performed to evaluate independent prognostic factors.RESULTS:Serum CA242,CA125,and CA199 levels in the GBC group were significantly higher when compared with those in the benign gallbladder disease and healthy control groups(P<0.01).With a single tumor marker for GBC diagnosis,the sensitivity of CA199 was the highest(71.7%),with the highest specificity being in CA242(98.7%).Diagnostic accuracy was highest with a combination of CA199,CA242,and CA125(69.2%).CA242 could be regarded as a tumor marker of GBC infiltration in the early stage.The sensitivity of CA199 and CA242 increased with progression of GBC and advanced lymph node metastasis(P<0.05).The78 GBC patients were followed up for 6-12 mo(mean:8 mo),during which time serum CA199,CA125,and CA242 levels in the recurrence group were significantly higher than in patients without recurrence(P<0.01).The post-operative serum CA199,CA125,and CA242levels in the non-recurrence group were significantly lower than those in the GBC group(P<0.01).Multivariate survival analysis using a Cox proportional hazards model showed that cancer of the gallbladder neck and CA199 expression level were independent prognostic factors.CONCLUSION:CA242 is a marker of GBC infiltration in the early stage.CA199 and cancer of the gallbladder neck are therapeutic and prognostic markers. | Yun-Feng Wang Fei-Ling Feng Xu-Hong Zhao Zhen-Xiong Ye He-Ping Zeng Zhen Li Xiao-Qing Jiang Zhi-Hai Peng | 2014 | World Journal of Gastroenterology2014，20，14： | 37 |
| 3 | Advanced treatment of dyeing wastewater towards reuse by the combined Fenton oxidation and membrane bioreactor process显示文摘The performance of combined Fenton oxidation and membrane bioreactor (MBR) process for the advanced treatment of an effluent from an integrated dyeing wastewater treatment plant was evaluated. The experimental results revealed that under the optimum Fenton oxidation conditions (initial pH 5, H 2 O 2 dosage 17 mmol/L, and Fe 2+ 1.7 mmol/L) the average total organic carbon (TOC) and color removal ratios were 39.3% and 69.5% after 35 min of reaction, respectively. Results from Zahn-Wallens Test also represented that Fenton process was effective to enhance the biodegradability of the test wastewater. As for the further purification of MBR process, TOC removal capacity was examined at different hydraulic retention times (HRT) of 10, 18 and 25 hr. Under the optimum HRT of 18 hr, the average TOC concentration and color of the final MBR effluent were 16.8 mg/L and 2 dilution time, respectively. The sludge yield coefficient was 0.13 g MLSS/g TOC and TOC degradation rate was 0.078 kg TOC/(m 3 ·day). The final effluent of MBR can meet the reuse criteria of urban recycling water-water quality standard for miscellaneous water consumption GBT18920-2002. | Fei Feng Zhenliang XU Xiaohuan Li Wenting You Yang Zhen | 2010 | Journal of Environmental Sciences2010，22，11： | 27 |
| 4 | Spatial patterns of ecological carrying capacity supply-demand balance in China at county level显示文摘一个平衡生态的带的能力和它的理解是重要的为人的类型完成持续开发。这里,生态的带的能力的概念被用于测量在人和自然之间的相关性。在供应和需求之间的瓷器生态的平衡成为了一颗全球担心并且广泛地被辩论。在这研究,生态的脚印方法被用来生态的带分析瓷器的供应要求平衡能力。第一,生态的供应和需求平衡计算、评估,并且第二,生态的带能力索引(ECCI ) 在 2007 为中国的每个县被导出,并且最后,这份报纸系统地评估了中国的生态的带能力供应要求平衡。结果证明生态的赤字看起来是在在县规模的 2007 中国的生态的带的能力供应要求平衡的主要特征。一般来说,超过五分之四张中国人口在不到三分之一个个陆地区域和超过三分之二个陆地区域被集中被不到五分之一个张人口住在。生态的带能力要求供应的空间分发被失衡从到富裕的重要过载从对中国的西北的部分东南。它看起来在在被候鸟吸引并且有通常更高的人口密度的沿海的区域定位的区域更主导。与在中国的快速的发展和都市化趋势一起,在这些区域的生态的赤字将变得更严重。 | LIU Dong FENG Zhiming YANG Yanzhao YOU Zhen | 2011 | Journal of Geographical Sciences2011，21，5： | 27 |
| 5 | Relationship between Cognition Function and Hippocampus Structure after Long-term Microwave Exposure显示文摘Objective To analyze the effects of long-term microwave exposure on hippocampal structure and function in the rat.Methods Experiments were performed on 184 male Wistar rats(three exposure groups and a sham group).Microwaves were applied daily for 6 min over 1 month at average power densities of 2.5,5,and 10 mW/cm2.Learning and memory abilities were assessed by Morris water maze.High performance liquid chromatography was used to detect neurotransmitter concentrations in the hippocampus.Hippocampal structures were observed by histopathological analysis.Results Following long-term microwave exposure there was a significant decrease in learning and memory activity in the 7 d,14 d,and 1 m in all three microwave exposure groups.Neurotransmitter concentrations of four amino acids(glutamate,aspartic acid,glycine,and gamma-aminobutyric acid) in hippocampus were increased in the 2.5 and 5 mW/cm2 groups and decreased in the 10 mW/cm2 group.There was evidence of neuronal degeneration and enlarged perivascular spaces in the hippocampus in the microwave exposure groups.Further,mitochondria became swollen and cristae were disordered.The rough endoplasmic reticulum exhibited sacculated distension and there was a decrease in the quantity of synaptic vesicles.Conclusion These data suggest that the hippocampus can be injured by long-term microwave exposure,which might result in impairment of cognitive function due to neurotransmitter disruption. | ZHAO Li PENG Rui Yun WANG Shui Ming WANG Li Feng GAO Ya Bing DONG Ji LI Xiang SU Zhen Tao | 2012 | Biomedical and Environmental Sciences2012，25，2： | 27 |
| 6 | Implementation of Envelope Analysis on a Wireless Condition Monitoring System for Bearing Fault Diagnosis显示文摘Envelope analysis is an effective method for characterizing impulsive vibrations in wired condition monitoring(CM)systems. This paper depicts the implementation of envelope analysis on a wireless sensor node for obtaining a more convenient and reliable CM system. To maintain CM performances under the constraints of resources available in the cost effective Zigbee based wireless sensor network(WSN), a low cost cortex-M4 F microcontroller is employed as the core processor to implement the envelope analysis algorithm on the sensor node. The on-chip 12 bit analog-to-digital converter(ADC) working at 10 k Hz sampling rate is adopted to acquire vibration signals measured by a wide frequency band piezoelectric accelerometer. The data processing flow inside the processor is optimized to satisfy the large memory usage in implementing fast Fourier transform(FFT) and Hilbert transform(HT). Thus, the envelope spectrum can be computed from a data frame of 2048 points to achieve a frequency resolution acceptable for identifying the characteristic frequencies of different bearing faults. Experimental evaluation results show that the embedded envelope analysis algorithm can successfully diagnose the simulated bearing faults and the data transmission throughput can be reduced by at least 95% per frame compared with that of the raw data, allowing a large number of sensor nodes to be deployed in the network for real time monitoring. | Guo-Jin Feng James Gu Dong Zhen Mustafa Aliwan Feng-Shou Gu Andrew D.Ball | 2015 | International Journal of Automation and computing2015，12，1： | 28 |
| 7 | Regulatory T cells as a new therapeutic target for atherosclerosis显示文摘动脉粥样硬化是贡献 T 和 B 房间免疫者回答的过多的激活的 self-self-antigens 和 non-self-antigens 引起的自体免疫的疾病。这些回答进一步加重脉管的 infiammation 并且经由释放 pro-infiammatory cytokines 支持到匾的动脉粥样硬化和危险的前进。特别地,规章的 T 房间( Tregs )由压制象 T 和 B 房间,生来的杀手( NK )房间,单核白血球,和树枝状的房间( DC )那样的各种各样的房间的有免疫力的回答作为主要 immunoregulatory 房间导致并且维持有免疫力的动态平衡和忍耐,象由 secreting 一样处于生理、病理学的状态的禁止的 cytokines interleukin ( IL )-10, IL-35 和抄写生长因素(TGF-)。众多的证据证明 Treg 的减少的数字和机能障碍可以是在动脉粥样硬化致病的 involveved。增加或恢复并且改进 Tregs 的抑制免疫力的能力数字可以用作基本免疫疗法对待动脉粥样硬化患者心血管的疾病。在这篇文章,我们 briefiy 介绍 Treg 子集的当前的知识,总结在 Tregs 和动脉粥样硬化开发之间的关系,并且讨论调整为动脉粥样硬化致病和匾稳定性的改进的预防的 Tregs 的可能性。尽管对动脉粥样硬化的调停 Treg 的保护的准确分子的机制尚待被阐明,为指向 Tregs 的规定的策略可以为动脉粥样硬化患者的预防和治疗提供特定、重要的途径心血管的疾病。 | Han-xiao OU Bing-bing GUO Qi LIU Yu-kun LI Zhen YANG Wen-jie FENG Zhong-cheng MO | 2018 | Acta Pharmacologica Sinica2018，39，8： | 24 |
| 8 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 9 | Resuscitation therapy for traumatic brain injuryinduced coma in rats:mechanisms of median nerve electrical stimulation显示文摘In this study, rats were put into traumatic brain injury-induced coma and treated with median nerve electrical stimulation. We explored the wake-promoting effect, and possible mechanisms, of median nerve electrical stimulation. Electrical stimulation upregulated the expression levels of orexin-A and its receptor OX1 R in the rat prefrontal cortex. Orexin-A expression gradually increased with increasing stimulation, while OX1 R expression reached a peak at 12 hours and then decreased. In addition, after the OX1 R antagonist, SB334867, was injected into the brain of rats after traumatic brain injury, fewer rats were restored to consciousness, and orexin-A and OXIR expression in the prefrontal cortex was downregulated. Our findings indicate that median nerve electrical stimulation induced an up-regulation of orexin-A and OX1 R expression in the prefrontal cortex of traumatic brain injury-induced coma rats, which may be a potential mechanism involved in the wake-promoting effects of median nerve electrical stimulation. | Zhen Feng Ying-jun Zhong Liang Wang Tian-qi Wei | 2015 | Neural Regeneration Research2015，10，4： | 23 |
| 10 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 11 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 12 | DESIGN OF 6-AXIS FORCE/TORQUE SENSOR BASED ON STEWART PLATFORM RELATED TO ISOTROPY显示文摘DESIGNOF6AXISFORCE/TORQUESENSORBASEDONSTEWARTPLATFORMRELATEDTOISOTROPYWangHongruiGaoFengHuangZhenMechanicalEngineeringInstit... | Wang, Hongrui Gao, Feng Huang, Zhen | 1998 | Chinese Journal of Mechanical Engineering1998，11，3： | 19 |
| 13 | Histological Subtypes of Lung Cancer in Chinese Males from 2000 to 2012显示文摘Objective To characterize the histological and epidemiological features of male lung cancer patients in China. Methods The demographic and histological information about male lung cancer patients identified from 2000-01-01 to 2012-12-31,was collected from the Cancer Hospital of the Chinese Academy of Medical Sciences. Relative frequencies(RF) were estimated for major histological subtypes and compared according to the years of diagnosis and birth. Results The RF of adenocarcinoma(ADC) increased from 21.96% to 43.36% and the RF of squamous cell carcinoma(SCC) decreased from 39.11% to 32.23% from 2000 to 2012 in the 15 427 male lung cancer patients included in this study(Z=17.909,P<0.0001; Z=-6.117,P<0.0001). The RF of ADC increased from 28.72% in 2000-2004,36.88% in 2005-2008 to 48.61% in 2009-2012 in patients born after 1960. The age-adjusted RF of ADC in 2007-2012 increased consistently in all the investigated areas. Conclusion The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors. Smoke-free policies rather than modifying tobacco products should be enforced. | ZOU Xiao Nong LIN Dong Mei WAN Xia CHAO Ann FENG Qin Fu DAI Zhen YANG Gong Huan LV Ning | 2014 | Biomedical and Environmental Sciences2014，27，1： | 19 |
| 14 | Comparison of Undernutrition Prevalence of Children under 5 Years in China between 2002 and 2013显示文摘Objective To describe the undernutrition status of children under 5-year in China, and study the trend between 2002 and 2013. Methods The study was based on two national surveys. Undernutrition was determined against WHO's 2006 growth standards. The prevalence in 2013 and 2002 was weighted by China sixth National Population Census(2010). The relationship between undernutrition and gender/age groups/different areas use weighted logistic regression. Results The results indicated the overall prevalence of stunting, underweight, and wasting of Chinese children under 5-year was 8.1%, 2.4%, and 1.9% in 2013, respectively. The prevalence of stunting was higher for children aged 12-47 month, while underweight was higher for children aged 48-59 month. The prevalence of undernutrition was higher in rural areas than in urban areas, especially in poor rural areas. There was a decline of stunting, underweight, and wasting between 2002 and 2013 among the children, with greater reduction in rural areas than in urban areas. Conclusion The prevalence of undernutrition of children under 5-year remains high in rural areas especially in poor rural areas in China. It is urgent to take action to control undernutrition in the vulnerable areas and subgroups. | YU Dong Mei ZHAO Li Yun YANG Zhen Yu CHANG Su Ying YU Wen Tao FANG Hong Yun WANG Xun YU Dan GUO Qi Ya XU Xiao Li FANG Yue Hui ZHAO Wen Hua YANG Xiao Guang DING Gang Qiang LIANG Xiao Feng | 2016 | Biomedical and Environmental Sciences2016，29，3： | 18 |
| 15 | Influence of Information Technology on Social Spatial Behaviors of Urban Residents——Case of Nanjing City in China显示文摘Taking Nanjing as a case, the paper explains the spatial behavior differences existing in the information technology use among different groups of residents and households, by virtue of analyzing the survey data of urban households in the 11 districts of Nanjing, from the social, spatial, life and other non-technical angles. Also it makes various analyses and evaluation quantitatively and qualitatively on the social and spatial effect of information technology. The results show that the new technology is changing the social spatial behaviors of urban residents. New behavioral spaces of urban family such as telecommuting, email and QQ have begun to emerge. With the help of Internet, the communication scope of families has expanded greatly, and more new forms of publicizing community information have begun to emerge. Telecommunication contact forms have been developing swiftly, and their frequencies of contact have been increasing dramatically. | ZHEN Feng WEI Zongcai | 2008 | Chinese Geographical Science2008，18，4： | 18 |
| 16 | Modeling study of residence time and water age in Dahuofang Reservoir in China显示文摘Understanding the dynamics of water renewal in a reservoir is essential when the transport and fate of dissolved substances are evaluated.A three-dimensional hydrodynamic model was implemented to compute average residence time and water age in Dahuofang Reservoir in China.The model was verified for a one-year time period in 2006.A simulation reproduced intra-annual variation of mixing represented by the fall/winter mixing and the spring/summer stratification.The simulated variation of vertical thermal structures also matched observation.The spatially varying average residence times and age distribution were investigated through a series of numerical experiments using a passively dissolved and conservative tracer as a surrogate.Residence time estimations yield a broad range of values depending on the position.The average residence time for a tracer placed at the head of the reservoir under high-,mean-,and low flow conditions was found to be about 125,236 and 521 days,respectively.The age simulation reveals that the age distribution is a function of the freshwater discharge.In the vertical direction,the age of the surface layers is larger than that of the bottom layers and the age difference between the surface and bottom layers decreases further downstream.The density-induced circulation plays an important role in the circulation in the reservoir,and can generate vertical age distribution in the reservoir.These findings provide useful information for understanding the transport process in Dahuofang Reservoir that can be used to assist the water quality management of the reservoir. | SHEN YongMing WANG JinHua ZHENG BingHui ZHEN Hong FENG Yu WANG ZaiXing YANG Xu | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，1： | 18 |
| 17 | An Empirical Study on Chinese City Network Pattern Based on Producer Services显示文摘Globalization and informatization have accelerated city networking process over the world, which makes research on city network a hot topic in the fields of urban geography and economic geography. With Chinese economic structure adjustment and city economic growth, producer services have begun to play an increasingly important role in city-region networking. This paper employs the methodology of world city network to analyze and explain the spatial development characteristics of China's urban network system based on the data of nationwide producer services enterprise network. The research result indicated that the distribution of producer services network has a positive effect on the development of Chinese city networks. City network connectivity is closely related to the significance of city in producer services development, and the former will gradually decline with the drop of the latter. Accordingly, the 64 cities can be divided into the national central cities, regional central cities, sub-regional central cities and local central cities in accordance with their position and role in the nationwide producer services network. It is concluded that high-grade cities with quality producer services dominate the pattern of Chinese city networks and there emerges three spatial agglomerations of producer services enterprises in Changjiang (Yangtze) River Delta, Zhujiang (Pearl) River Delta and Beijing-Tianjin-Tangshan Economical Region. Moreover, the distribution of different producer services industry varies from city to city, which also affects the characteristics of network development. | ZHEN Feng WANG Xia YIN Jun ZHANG Min | 2013 | Chinese Geographical Science2013，23，3： | 17 |
| 18 | A Theoretical Framework and Methodology for Urban Activity Spatial Structure in E-society: Empirical Evidence for Nanjing City, China显示文摘The existing researches on the influence of information and communication technology(ICT) are mainly focused on human activity, whilst with few efforts on urban space. In the e-society, the widespread adoption of ICT devices not only affects almost every aspect of people′s daily life and thereby reshapes the spatial development of regions and cities, but also generates a large amount of real-time activity data with location information. These georeferenced data, however, have relatively recently attracted attention from geographers. Adapted from Lynch′s framework based on people′s perceptions, this paper proposes a framework of urban spatial structure based on people′s actual activity, including five elements, namely activity path, activity node, central activity zone(CAZ), activity district, and activity edge. In the empirical study, by using one week′s check-in tweets(from February 25 to March 3 in 2013) collected in Nanjing City, the five elements are recognized and analyzed. Through the comparison between our results and urban spatial structure based on population(and land use), we argue that ICT uses: 1) lead to polarize, rather than to smooth, the urban structural hierarchy, due to the dual role of distance; 2) enable a partial decoupling of activity and activity space node, which challenges our conventional understanding of the role of home and the utility of travel; 3) blur the boundaries of activity districts and hence may play a positive role in enriching districts′ functions, which should not be overlooked in the current urban transformation in China. | WANG Bo ZHEN Feng WEI Zongcai GUO Shu CHEN Tingting | 2015 | Chinese Geographical Science2015，25，6： | 17 |
| 19 | Rubber plantation and its relationship with topographical factors in the border region of China, Laos and Myanmar显示文摘橡胶种植园是在东南亚洲的主要陆地使用类型。监视橡胶种植园的空间时间的模式为地区性的陆地资源开发, eco 环境的保护,和维持的边阶安全是重要的。与遥感技术,我们分析了橡胶分发模式并且空间时间动态;与 GIS 和种的紧张(PI ) 的一个最新建议的索引一起,我们进一步确定了在在 1980 和 2010 之间的中国,老挝和 Myanmar (BRCLM ) 的边阶区域的橡胶种植园上的地形学的因素的影响和限制。结果显示出那:(1 ) 作为在这的主导的陆地使用类型毗邻区域,橡胶种植园的面积是在 2010 的 6014 km2,为 8.17% 全部的区域的财务。从橡胶种植园结构看,比率成熟 --(10 年) 并且年轻橡胶种植园(< 10 年) 是 5:7。(2 ) 从 1980 ~ 2010,在 BRCLM 显著地扩展的橡胶种植园,从 705 km2 到 6014 km2,将近九次。橡胶种植园的分发特征变化了从专注向分散,从在内的边阶到外面,并且作为中心与 Jinghong 城市在所有方向进一步膨胀了。(3 ) 由地形学的因素限制了,多于在在 600 和 1000 m 之间的适当举起坡度集中的橡胶种植园的 4/5 比例,很少在 BRCLM 在 1200 m 以外发生在举起。将近橡胶种植园的 2/3 专注于 8 的斜坡吗? | LIU xiaona FENG Zhiming JIANG Luguang LI Peng LIAO Chenhua YANG Yanzhao YOU Zhen | 2013 | Journal of Geographical Sciences2013，23，6： | 17 |
| 20 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
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