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| 1 | Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation. | Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson | 2016 | World Journal of Gastroenterology2016，22，21： | 3 |
| 2 | Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype. | C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 3 | Acute coronary syndromes in young patients: Presentation, treatment and outcome显示文摘 | Andreas W. Schoenenberger Dragana Radovanovic Jean-Christophe Stauffer Stephan Windecker Philip Urban Gregor Niedermaier Pierre-Frédéric Keller Felix Gutzwiller Paul Erne | 2009 | International Journal of Cardiology2009，，3： | 2 |
| 4 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 5 | Successful bronchoscopie placement of tracheobronchial stents without fluoroscopy显示文摘 | Felix H Heinrieh D Beeker | 2001 | Chest2001，119，6： | 1 |
| 6 | 显示文摘 | Felix SB Staudt A Stanglv D | 2002 | J Am Coll Cardiol2002，35，： | 1 |
| 7 | Expression of metastases-associated genes in cervical cancers resected in proliferative and secretory phases of the menstrual cycle显示文摘 | Formenti S Felix J Salonga D | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 8 | Challenge of Swiss Arbitral Awards- se- lected Statistical Data as 2013显示文摘 | FELIX D DAVID R | 2014 | ASA Bulletin2014，，32： | 1 |
| 9 | Panhandle PCR:a technical advance to amplify MLL genomic translocation breakpoints显示文摘 | FELIX C A JONES D H | 1998 | Leukemia1998，12，6： | 1 |
| 10 | Granular flows in a rotating drum: The scaling law between velocity and thickness of the flow 显示文摘 | FELIX G FALK V D’Ortona U | 2007 | Eur Phys J E2007，22，1： | 1 |
| 11 | JOE : A mobile, inverted pendulum显示文摘 | Felix G Aldo D A Silvio C | 2002 | IEEE Transaction on Industrial Electronics2002，49，1： | 1 |
| 12 | CAS Lib 显示文摘 | Sachetto-Martins G Fernandes L D Felix D | 1995 | Int J Plant Sci1995，156，： | 1 |
| 13 | Comparison of accelerated solvent extraction with conventional solvent extraction for organophosphorus pesticides and herbicides显示文摘 | Ezzell J L Richter B E Felix W D | 1995 | LC/GC1995，13，5： | 1 |
| 14 | JOE: A mobile inverted Pendulum 显示文摘 | Felix G Aldo D A Silvio C | 2002 | IEEE Transactions on Industrial Electronics2002，49，1： | 1 |
| 15 | The p53 gene in pediatric therapy-related leukemia and myelodysplasia 显示文摘 | Hosler MR Provisor D | 1996 | Blood1996，87，： | 1 |
| 16 | CFD calculation of a mixed flow pump characteristic from shutoff to maximum flow显示文摘 | Felix A M Peter H Philippe D | 2002 | Journal of Fluids Engineering ASME2002，124，3： | 1 |
| 17 | Solid-phase peptide synthesis of somatostatin using mild base cleavage of N alpha-9-fluorenylrnethyloxy- carbonyl amino acids显示文摘 | CHANG C D FELIX A M JIMENEZ M H | 1980 | Pept Protein Res1980，15，5： | 1 |
| 18 | Risk of residual invasive disease in women with microinvasive squamous cancer in a conization specimen显示文摘 | Roman L D Felix J C Muderspach L I | 1997 | Obstet Gynecol1997，90，： | 1 |
| 19 | Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats显示文摘 | Felix R Levin E D | 1997 | Neuroscience1997，81，4： | 1 |
| 20 | Identification of potential markers for the detection of pancreatic cancer through comparative serum protein expression profiling 显示文摘 | Ehmann M Felix K Hartmann D | 2007 | Pancreas2007，34，2： | 1 |
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