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| 1 | Hyperthermia in combined treatment of cancer显示文摘 | P Wust B Hildebrandt G Sreenivasa B Rau J Gellermann H Riess R Felix PM Schlag | 2002 | Lancet Oncology2002，，8： | 2 |
| 2 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 3 | Plants have a sensitive perception system for the most conserved domain of bacterial flagellin 显示文摘 | FELIX G DURAN JD VOLKO S | 1999 | The Plant Journal1999，18，3： | 1 |
| 4 | A method for the determination of volatile N-nitrosamines in food by HS-SPME-GC-TEA 显示文摘 | Raquel A Felix G R Susanne R | 2005 | Food Chemistry2005，91，1： | 1 |
| 5 | Parallcl ization of the Scatter Search for the p median Problem 显示文摘 | FELIX G L BELEN M B JOSE A M P | 2003 | Parallel Computing2003，29，5： | 1 |
| 6 | Studies on energetic compounds part 36 :Evaluation of transition metal salts of NTO as burning rate modifiers for HTPB-AN composite solid propellants显示文摘 | Singh G Felix S P | 2003 | Combustion and Flame2003，135，： | 1 |
| 7 | A single locus determines sensitivity to bacterial flagellin in Arabidopsis thaliana显示文摘 | GOMEZ-GOMEZ L FELIX G BOLLER T | | 0，，： | 1 |
| 8 | Level crossing analysis of leakage current envelope of polluted insulators显示文摘 | Felix Amarh George G Karady Raji Sundararajan | 2001 | IEEE Power Engineering Review2001，21，8： | 1 |
| 9 | The plant wound hormone systemin binds with the N-terminal part to its receptor but needs the C-terminal part to activate it显示文摘 | MEINDL T BOLLER T FELIX G | 1998 | The Plant Cell1998，10，： | 1 |
| 10 | Granular flows in a rotating drum: The scaling law between velocity and thickness of the flow 显示文摘 | FELIX G FALK V D’Ortona U | 2007 | Eur Phys J E2007，22，1： | 1 |
| 11 | Comparison of the efficacy of the aromatase inhibitor letrozole and clomiphene citrate as adjuvants to recombinant follicle - stimulating hormone in controlled ovarian hypers- timulation : a prospective randomized blinded clinical tyial 显示文摘 | Barroso G Menocal G Felix H | 2006 | Fertil Steril2006，86，5： | 1 |
| 12 | Ultra_fine structure of the hydroxyapa- tite amorphous phase in noninfectious phosphate renal calculi 显示文摘 | Mark~ta Z Otakar S Felix G | 2012 | Urology2012，79，4： | 1 |
| 13 | JOE : A mobile, inverted pendulum显示文摘 | Felix G Aldo D A Silvio C | 2002 | IEEE Transaction on Industrial Electronics2002，49，1： | 1 |
| 14 | CAS Lib 显示文摘 | Sachetto-Martins G Fernandes L D Felix D | 1995 | Int J Plant Sci1995，156，： | 1 |
| 15 | JOE: A mobile inverted Pendulum 显示文摘 | Felix G Aldo D A Silvio C | 2002 | IEEE Transactions on Industrial Electronics2002，49，1： | 1 |
| 16 | Applying RCM in larger scale systems:A case study with railway networks显示文摘 | JESUS C JOSE M P FELIX G C | 2003 | Reliability Engineering and System Safety2003，，82： | 1 |
| 17 | Resistance to disease in the hybrid Nicotian glutinosa × Nicotiana debneyi is associated with high constitutive level of β-1,3-glucanase, chitinase,per-oxidase and polyphenyloxidase 显示文摘 | Goy P A Felix G Metraux J P | 1992 | Physiological and Molecular Plant Pathology1992，41，1： | 1 |
| 18 | Short-term hemodynamic effects of immunoadsorption in dilated cardiomyopathy显示文摘 | Dorffel WV Felix SB Wallukat G | 1997 | Circulation1997，95，： | 1 |
| 19 | Maintenance strategy based on a multicriterion classification of equipments 显示文摘 | C G L H Felix J R C Jose | 2006 | Reliability Engineering and System Safety2006，，91： | 1 |
| 20 | TACS:A Trust Model for P2P Networks显示文摘 | Felix G M Gregorio M P Antonio F G S | 2009 | Wireless Personal Communications2009，51，1： | 1 |
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