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    题名 作者 年代 出处 被引量
1胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 2017中华高血压杂志2017,25,9:2
2显示文摘 Chirkin A P Demyanets L N Doronin S N Genkina E A Ivanov-Shits A K Kondratyuk I P Maksimov B A Mel'Nikov O K Muradyan L N Simonov V I Timofeeva V A Superionic conductors Li3M2(PO4)3 (M=Fe Sc Cr): Synthesis structure and electrophysical properties 1990Solid State Ionics1990,38,:1
3Phthalates determination in physiological saline solutions by HPLC-ES-MS显示文摘Pérez Feás C Barciela Alonso M C Pe?a-Vázquez E 2008Talanta2008,75,5:1
4Predicting Performance of Design-Build and Design-Bid-Build Projects显示文摘Ling F F Y Chon L C Chong E Fe L P 0,,01:1
5DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokineproduction 显示文摘Caparros E Munoz P Sierra FE 2006Blood2006,107,10:1
6Effects of 7 irradia tion on caprolactam level from multilayer PA-6 films for food packaging: Development and validation of a gas chromatographic method显示文摘Arau'jo H P Fe'lix J S Manzoli J E 2008Radiation Physics and Chemistry2008,77,7:1
7Factors influencing the outcome of closed tibial fractures treatedwith functional bracing 显示文摘Sarmiento A Sharpe FE Ebramzadeh E Normand P ShankwilerJ 1995Clin Orthop Relat Res1995,,315:1
8Nano- particulate alternatives for drug delivery 显示文摘ADAIR J H PARET'FE M P ALTNOGLU E I 2010Acs Nano2010,4,9:1
9Growing Prof itable or Growing from Prof its:Putting the Horse in front of the Cart-显示文摘Dav id s s on P S t e f fe n s P F it z s i m mon sJ 2009Journal ofBusiness Venturing2009,24,4:1
10Renal sympa- thetic denervation in patients with treatment-resistant hyperten- sion after witnessed intake of medication before qualifying ambula- tory blood pressure显示文摘Fadl Elmula FE Hoffmann P Fossum E 2013Hypertension2013,62,3:1
11How to structure and prioritize information needs in support of monito- ring design for integrated coastal management 显示文摘VUGTEVEEN P VAN KATWIJK M M ROUWET'FE E 2014Journal of Sea Research2014,,86:1
12Analysis of genetic variability of South American wild rice populations(Oryza glurnnepatula)with isozymes and RAPD markers显示文摘Buso G S C Rangel P H Fe rreira M E 1998Molecular Ecology1998,7,:1
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