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| 1 | Characterization of focal liver masses using acoustic radiation force impulse elastography显示文摘AIM:To investigate the diagnostic performance of acoustic radiation force impulse(ARFI) elastography for characterizing focal liver mass by quantifying their stiffness.METHODS:This prospective study included 62 patients with a focal liver mass that was well visualized on conventional ultrasonography performed in our institution from February 2011 to November 2011.Among them,12 patients were excluded for ARFI measurement failure due to a lesion that was smaller than the region of the interest and at an inaccessible location(deeper than 8 cm)(n = 7) or poor compliance to hold their breath as required(n = 5).Finally,50 patients with valid ARFI measurements were enrolled.If a patient had multiple liver masses,only one mass of interest was chosen.The masses were diagnosed by histological examination or clinical diagnostic criteria.During ultrasonographic evaluation,stiffness,expressed as velocity,was checked 10 times per focal liver mass and the surrounding liver parenchyma.RESULTS:After further excluding three masses that were non-diagnostic on biopsy,a total of 47 focal mass lesions were tested,including 39(83.0%) malignant masses [24 hepatocellular carcinomas(HCC),seven cholangiocellular carcinomas(CCC),and eight liver metastases] and eight(17.0%) benign masses(five hemangiomas and three focal nodular hyperplasias,FNH).Thirty-seven(74.0%) masses were confirmed by histological examination.The mean velocity was 2.48 m/s in HCCs,1.65 m/s in CCCs,2.35 m/s in metastases,1.83 m/s in hemangiomas,and 0.97 m/s in FNHs.Although considerable overlap was still noted between malignant and benign masses,significant differences in ARFI values were observed between malignant and benign masses(mean 2.31 m/s vs 1.51 m/s,P = 0.047),as well as between HCCs and benign masses(mean 2.48 m/s vs 1.51 m/s,P = 0.006).The areas under the receiver operating characteristics curves(AUROC) for discriminating the malignant masses from benign masses was 0.724(95%CI,0.566-0.883,P = 0.048),and the AUROC for discriminating HCCs from benign masses was 0.813(95%CI,0.649-0.976,P = 0.008).To maximize the sum of sensitivity and specificity,an ARFI value of 1.82 m/s was selected as the cutoff value to differentiate malignant from benign liver masses.Furthermore,the cutoff value for distinguishing HCCs from benign masses was also determined to be 1.82 m/s.The diagnostic performance of the sum of the ARFI values for focal liver masses and the surrounding liver parenchyma to differentiate liver masses improved(AUROC = 0.853;95%CI,0.745-0.960;P = 0.002 in malignant liver masses vs benign ones and AUROC = 0.948;95%CI,0.896-0.992,P < 0.001 in HCCs vs benign masses).CONCLUSION:ARFI elastography provides additional information for the differential diagnosis of liver masses.However,our results should be interpreted in clinical context,because considerable overlap in ARFI values existed among liver masses. | Hana Park Jun Yong Park Do Young Kim Sang Hoon Ahn Chae Yoon Chon Kwang-Hyub Han Seung Up Kim | 2013 | World Journal of Gastroenterology2013，19，2： | 22 |
| 2 | Low grade gastric mucosa associated lymphoid tissue lymphoma:Treatment strategies based on 10 year follow-up显示文摘AIM:To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities.METHODS:A total of 55 patients with MALTOMA from May 1992 to August 2002 were retrospectively reviewed.RESULTS: Complete remission was obtained in 24 (82.8%) of 29 patients treated with anti Helicobacter pylori(H pylori) regimen only. The duration to reach complete remission was 12 months (85 percentile, 2-33 months).Five patients showed complete remission with radiation therapy (26-86 months).Two of them were Hpyloritreatment failure cases.CONCLUSION: Hpylorieradication is an effective primary treatment option for low grade MALTOMA and radiation therapy could be considered in patients with no evidence of Hpyloninfection or who do not respond to Hpylorieradication therapy 12 months after successful eradication. | Sang Kil Lee Yong Chan Lee Jae Bock Chung Chae Yoon Chon Young Myoung Moon Jin Kyung Kang In-Suh Park Chang Ok Suh Woo Ik Yang | 2004 | World Journal of Gastroenterology2004，10，2： | 12 |
| 3 | Hepatocellular carcinoma in Budd-Chiari syndrome:A single center experience with long-term follow-up in South Korea显示文摘AIM:To evaluate long-term clinical course of BuddChiari syndrome(BCS) and predictive factors associated with the development of hepatocellular carcinoma(HCC) and survival.METHODS:We analyzed 67 patients with BCS between June 1988 and May 2008.The diagnosis of BCS was confirmed by hepatic venous outflow obstruction shown on abdominal ultrasound sonography,computed tomography,magnetic resonance imaging,or venography.The median follow-up period was 103 ± 156 [interquartile range(IQR)] mo.RESULTS:The median age of the patients was 47 ± 16(IQR) years.At diagnosis,54 patients had cirrhosis,25(37.3%) Child-Pugh class A,23(34.3%) Child-Pugh class B,and six(9.0%) patients Child-Pugh class C.During the follow-up period,HCC was developed in 17 patients,and the annual incidence of HCC in patients with BCS was 2.8%.Patients in HCC group(n = 17) had higher hepatic venous pressure gradient(HVPG) than those in non-HCC group(n = 50)(21 ± 12 mmHg vs 14 ± 7 mmHg,P = 0.019).The survival rate of BCS patients was 86.2% for 5 years,73.8% for 10 years,and 61.2% for 15 years.In patients with BCS and HCC,survival was 79% for 5 years,43.1% for 10 years,and 21.5% for 15 years.CONCLUSION:The incidence of HCC in patients with BCS was similar to that in patients with other etiologic cirrhosis in South Korea.The HVPG is expected to provide additional information for predicting HCC development in BCS patients. | Hana Park Jin Young Yoon Kyeong Hye Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Jun Yong Park | 2012 | World Journal of Gastroenterology2012，18，16： | 12 |
| 4 | Expression patterns of cytokine,growth factor and cell cycle-related genes after partial hepatectomy in rats with thioacetamide-induced cirrhosis显示文摘瞄准:在与影响肝新生的因素的关系在对部分肝切除术的正常和硬变肝的回答检验差别。方法:肝硬化被 thioacetamide 的管理在老鼠导致。未经治疗的老鼠被用作控制。象肝脏硬化症的老鼠一样的控制老鼠受到 70% 部分肝切除术。在在肝切除术以后的不同时间点,肝被收集, cytokines,生长因素和房间周期蛋白质的层次被分析。结果:在肝切除术以后,当与直到 72 的控制相比 h 张贴肝切除术,肝脏硬化症的残余显著地表示了 cyclin D1,它的激酶搭挡, cdk4,和 cyclin E 的底层。当时,显著地, cyclin A 和 cdk2 的底层也被观察 cdk 禁止者, p27 显著地更高。另外,有的更低的 IL-6 比控制铺平的肝脏硬化症的组根本组织时间点直到 72 h 追随者切除术。结论:从我们的学习的数据证明在肝脏硬化症的残余的那个损害的肝新生与 cyclins 和 cdks 的低表示被联系。这可能是在将接着影响调整在新生过程期间涉及房间增长和新陈代谢的动态平衡的基因的抄写因素的行动的硬变肝残余的低 IL-6 层次的后果。 | Shu Yang Chon Kar Leow Theresa May Chin Tan | 2006 | World Journal of Gastroenterology2006，12，7： | 8 |
| 5 | 实时三维经胸超声心动图测量缩流面积评价主动脉瓣反流显示文摘目的应用实时三维经胸超声心动图(3D-TTE)测量缩流面积(VCA)评价主动脉瓣反流。方法将56例主动脉瓣反流患者的三维测量的VCA以及二维经胸超声心动图(2D-TTE)测量的缩流宽度与主动脉根部造影和外科手术的主动脉瓣反流程度相比较。结果3D—TTE测得的VCA与主动脉根部造影和外科手术的主动脉瓣反流程度密切相关(r=0.95),无明显重叠。2D—TTE测得的缩流宽度亦与主动脉根部造影和手术的主动脉瓣反流程度有很好的相关性(r=0.92),但有较多的重叠。以主动脉根部造影和外科手术为主动脉瓣反流程度的标准,三维测得的1~4度主动脉瓣反流的相应VCA分别为≤0.19cm^2,0.2~0.39cm^2,0.4~0.59cm^2,≥0.6cm^2。结论实时3D—TTE彩色多普勒能准确评价主动脉瓣反流,且和主动脉根部造影有很好的相关性。 | 方理刚 Navin C.NANDA Ming Chon HSIUNG 程康安 朱文玲 | 2008 | 临床超声医学杂志2008，10，3： | 7 |
| 6 | 腹腔镜直肠癌根治术筋膜解剖与自主神经保护再认识显示文摘腹腔镜直肠癌根治术包括全直肠系膜切除术(TME)、D3淋巴结清扫术以及盆腔自主神经保护3个方面,手术目标为肿瘤根治和功能保护。在手术操作过程中,对于腹腔和盆腔筋膜解剖的理解有助于提高直肠癌TME质量和保护自主神经。手术操作进入盆腔后,对于直肠系膜固有筋膜层、盆腔脏层筋膜、腹下神经前筋膜、骶前筋膜、直肠周围韧带结构以及直肠前方Denonvilliers筋膜的辨识有助于保护盆腔自主神经,避免损伤。笔者重点介绍腹腔镜直肠癌根治术中,如何正确辨识盆腔筋膜结构,并应用筋膜解剖理念完成直肠癌TME,实现盆腔自主神经保护。 | 燕速 Seung-Hun Chon 马新福 赵康 陈筱乾 郭灿 王亮 刘成浩 | 2020 | 中华消化外科杂志2020，19，10： | 7 |
| 7 | Antiviral efficacy of lamivudine versus entecavir in patients with hepatitis B virus‐related advanced hepatocellular carcinoma显示文摘 | Hye Sun Shin Seung Up Kim Jun Yong Park Do Young Kim Kwang‐Hyub Han Chae Yoon Chon Oidov Baatarkhuu Sang Hoon Ahn | 2012 | Journal of Gastroenterology and Hepatology2012，，9： | 3 |
| 8 | Efficacy of switching to telbivudine plus adefovir in suboptimal responders to lamivudine plus adefovir显示文摘AIM:To examine the efficacy of telbivudine(LdT)+adefovir(ADV)vs continuation of lamivudine(LAM)+ADV in patients with LAM-resistant chronic hepatitis B(CHB)who show a suboptimal response to LAM+ADV.METHODS:This was a randomized,active-control,open-label,single-center,parallel trial.All eligible patients were enrolled in this study in Severance Hospital,Yonsei University College of Medicine,Seoul,South Korea,between March 2010 and March 2011.Hepatitis Be antigen(HBeAg)-positive CHB patients whose serum hepatitis B virus(HBV)DNA remained detectable despite at least 6 mo of LAM+ADV therapy were included.Enrolled patients were randomized to either switching to LdT(600 mg/d orally)plus ADV(10 mg/d orally)(LdT+ADV group)or to continuation with LAM(100 mg/d orally)plus ADV(10 mg/d orally)(LAM+ADV group),and were followed for 48 wk.One hundred and six patients completed the 48-wk treatment period.Serum HBV DNA,HBeAg status,liver biochemistry and safety were monitored at baseline and week 12,24,36 and 48.RESULTS:The duration of prior LAM+ADV treatment was 18.3(LdT+ADV)and 14.9 mo(LAM+ADV),respectively(P=0.131).No difference was seen in baseline serum HBV DNA between the two groups[3.66(LdT+ADV)vs 3.76(LAM+ADV)log10IU/mL,P=0.729].At week 48,although there was no significant difference in the mean reduction of serum HBV DNA from baseline between LdT+ADV group and LAM+ADV group(-0.81 vs-0.47 log10IU/mL,P=0.167),more patients in the LdT+ADV group had undetectable HBV DNA levels compared to those in the LAM+ADV group(30.2%vs 11.5%,P=0.019).Three patients with LdT+ADV treatment and 2 patients with LAM+ADV treatment achieved HBeAg loss.The patients in both groups tolerated the treatment well without serious adverse events.The proportion of patients with estimated glomerular filtration rate≥90 mL/min per 1.73 m2in the LdT+ADV group increased from 49.1%(26/53)at baseline to 58.5%(31/53)at week 48,while that in the LAM+ADV group decreased from 37.7%(20/53)at baseline to 30.2%(16/53)at week 48.CONCLUSION:The switch to LdT+ADV in suboptimal responders to LAM+ADV showed a significantly higher rate of virologic response at week 48.These results suggest that LdT+ADV could be a therapeutic option for patients who are unable to use enofovir disoproxil fumarate for any reason. | Hana Park Jun Yong Park Seung Up Kim Do Young Kim Kwang-Hyub Han Chae Yoon Chon Sang Hoon Ahn | 2013 | World Journal of Gastroenterology2013，19，43： | 3 |
| 9 | Outcome after curative resection for a huge (≥10 cm) hepatocellular carcinoma and prognostic significance of gross tumor classification显示文摘 | Gi Hong Choi Dai Hoon Han Dong Hyun Kim Sae Byeol Choi Chang Moo Kang Kyung Sik Kim Jin Sub Choi Young Nyun Park Jun Yong Park Do Young Kim Kwang-Hyub Han Chae Yoon Chon Woo Jung Lee | 2009 | The American Journal of Surgery2009，，5： | 2 |
| 10 | Risk-basedliquefaction potential evaluation using standardpenetration tests显示文摘 | Juang C H Chon C J Tao Jiang Andurs R D | 2000 | Canadian Geotechnical Journal2000，37，： | 2 |
| 11 | Controlled attenuation parameter ( CAP ) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population显示文摘 | Young Eun Chon Kyu Sik Jung Seung Up Kim Jun Yong Park Young Nyun Park Do Young Kim Sang Hoon Ahn Chae Yoon Chon Hye Won Lee Yehyun Park Kwang‐Hyub Han | 2014 | Liver Int2014，，1： | 2 |
| 12 | The Accuracy of Noninvasive Methods in Predicting the Development of Hepatocellular Carcinoma and Hepatic Decompensation in Patients With Chronic Hepatitis B显示文摘 | Young Eun Chon Eun Suk Jung Jun Yong Park Do Young Kim Sang Hoon Ahn Kwang-Hyub Han Chae Yoon Chon Kyu Sik Jung Seung Up Kim | 2012 | Journal of Clinical Gastroenterology2012，，6： | 2 |
| 13 | Web-based interactive visualization of 3D video mosaics using X3D standard显示文摘We present a method of 3D image mosaicing for real 3D representation of roadside buildings, and implement a Web-based interactive visualization environment for the 3D video mosaics created by 3D image mosaicing. The 3D image mo- saicing technique developed in our previous work is a very powerful method for creating textured 3D-GIS data without excessive data processing like the laser or stereo system. For the Web-based open access to the 3D video mosaics, we build an interactive visualization environment using X3D, the emerging standard of Web 3D. We conduct the data preprocessing for 3D video mosaics and the X3D modeling for textured 3D data. The data preprocessing includes the conversion of each frame of 3D video mosaics into concatenated image files that can be hyperlinked on the Web. The X3D modeling handles the representation of concatenated images using necessary X3D nodes. By employing X3D as the data format for 3D image mosaics, the real 3D representation of roadside buildings is extended to the Web and mobile service systems. | CHON Jaechoon LEE Yang-Won SHIBASAKI Ryosuke | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，7： | 2 |
| 14 | Douglas gemmill: determining fabrication orientations for rapid prototyping with stereolithography apparatus显示文摘 | Lan P T Chon S Y Chen L L | 1997 | Computer-Aided Design1997，29，1： | 2 |
| 15 | The rice narrow leaf2 and narrow leaf3 loci encode WUSCHEL ‐related homeobox 3 A ( O s WOX 3 A ) and function in leaf, spikelet, tiller and lateral root development显示文摘 | Sung‐Hwan Cho Soo‐Cheul Yoo Haitao Zhang Devendra Pandeya Hee‐Jong Koh Ji‐Young Hwang Gyung‐Tae Kim Nam‐Chon Paek | 2013 | New Phytol2013，，4： | 2 |
| 16 | Liver Stiffness Measurement Using Acoustic Radiation Force Impulse (ARFI) Elastography and Effect of Necroinflammation显示文摘 | Ki Yoon Sun Lim Jun Park Do Kim Sang Ahn Kwang-Hyub Han Chae Chon Mong Cho Jun Lee Seung Kim | 2012 | Digestive Diseases and Sciences2012，，6： | 2 |
| 17 | Antecedents of revisit intention显示文摘 | Seoho Urn Kaye Chon YoungHee Ro | 2006 | Annals of Tourism Research2006，33，4： | 1 |
| 18 | The response of skin disease to stress:changes in the severity of acne vulgaris as affected by examination stress显示文摘 | Susna Y chon Alexa B | 2003 | J Arch Dematol2003，139，： | 1 |
| 19 | Biological activity and quantification of suspected allelochemicals from alfalfa plant parts 显示文摘 | Chon S U Kim J D | 2002 | Crop Science2002，188，： | 1 |
| 20 | Metal contamination of soils and dusts in Seoul metropolitan city Korea 显示文摘 | Chon H T Kim K W Kim J Y | 1995 | Environmental Geochemistry & Health1995，17，： | 1 |
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