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| 1 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 2 | Effect of donor–recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis显示文摘 | Mary Eapen John P Klein Guillermo F Sanz Stephen Spellman Annalisa Ruggeri Claudio Anasetti Maria Brown Richard E Champlin Joan Garcia-Lopez Gareth Hattersely Gesine Koegler Mary J Laughlin Gerard Michel Samir K Nabhan Franklin O Smith Mary M Horowitz Eli | 2011 | Lancet Oncology2011，，13： | 2 |
| 3 | Seismic waves in stratified anisotropic media显示文摘 | Gerard J F Frazer L N | 1984 | Geophysical Journal of the Royal Astronomical Society1984，78，： | 1 |
| 4 | Nonlinear acoustic echo cancellation based on volterra filters 显示文摘 | G Alexandre F Gerard L B J Regine | 2003 | IEEE Transactions on Speech and Audio Processing2003，11，6： | 1 |
| 5 | Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203 显示文摘 | Gerard JP Conroy T Bonnetain F | 2006 | J Clin Oncol2006，24，28： | 1 |
| 6 | Acoustic transfer vectors for numerical modeling of engine显示文摘 | Gerard F Tournour M Masfi N Eleta 1 | 2002 | Sound and Vibration2002，，： | 1 |
| 7 | Seismic waves in stratified anisotropic media显示文摘 | Gerard J F Frazer L N | 1987 | Geophysical Journal of the Royal Astronomieal Society1987，91，： | 1 |
| 8 | Influence ofPOSS structure on the fire retardant properties of epoxy hybridnetworks 显示文摘 | FRANCHINI E GALY J GERARD J F | 2009 | Polymer Degradation and Stability2009，94，10： | 1 |
| 9 | Development of a meat-like process flavoring from soybean-based enzyme-hydrolyzed vegetable protein (E-HVP) 显示文摘 | Wu Y F Baek H H Gerard P D | 2000 | Joumal of Food Science2000，65，7： | 1 |
| 10 | Prognostic impact of matrix metalloproteinase gene polymorphisms in patients with heart failure according to the aetiology of left ventricular systohe dysfunction显示文摘 | Mizon- Gerard F de Groote P Lamblin N | 2004 | Eur Heart J2004，25，8： | 1 |
| 11 | Dynamic response of guyed masts显示文摘 | YOHANNA M F W and GERARD R M | 1998 | Engineering Structure1998，20，12： | 1 |
| 12 | Ultrasound-guided vacuum- assisted biopsy: review of 382 cases显示文摘 | Lantade R Hammou J C Gerard F | 2005 | J Radiol2005，86，9： | 1 |
| 13 | Cardiac troponin T in chest pain unit patients without ischemic electrocardiographic changes: angiographic correlates and long-term clinical outcomes显示文摘 | Christopher R deFilippi Monica Tocchi Rohit J Parmar Salvatore Rosanio Gerard Abreo Marjorie A Potter Marschall S Runge Barry F Uretsky | 2000 | Journal of the American College of Cardiology2000，，7： | 1 |
| 14 | Ultrasound-guided vacuum- assisted biopsy: review of 382 cases显示文摘 | Plantade R Hammou J C Gerard F | 2005 | J Radiol2005，86，91： | 1 |
| 15 | Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203显示文摘 | Gerard JP Conroy T Bonnetain F | 2006 | J Clin Oncol2006，24，28： | 1 |
| 16 | Nocturnal 02 onrichment of room air at high altitude increases daytime 02 Saturation without changing control of ventilation显示文摘 | Gerard A Powell F L | 2000 | High Alt Med Biol2000，1，3： | 1 |
| 17 | Structure analysis of PVA nanocomposites 显示文摘 | Kovarova L Kalendova A Gerard J F | 2005 | Macromolecular Symposium2005，221，： | 1 |
| 18 | Bilateral ureteral obstruction due to Saccharomyces cerevisiae fungus balls 显示文摘 | Senneville F Ajana F Gerard Y | 1996 | Clin Infect Dis1996，23，： | 1 |
| 19 | Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203显示文摘 | Gerard JP Conroy T Bonnetain F | 2006 | J Clin Oncol2006，24，28： | 1 |
| 20 | Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203显示文摘 | Gerard JP Conroy T Bonnetain F | 2006 | J Clin Oncol2006，24，28： | 1 |
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