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| 1 | Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-Ⅱ显示文摘 | Rosa Montes Gertrudis Ligero Laura Sanchez Purificacidn Catalina Teresa de la Cueva Ana Nieto Gustavo J Melen Ruth Rubio Javier Garcia-Castro Clara Bueno Pablo Menendez | 2009 | Cell Research2009，19，6： | 7 |
| 2 | ACIDIC FIBROBLAST GROWTH FACTOR REDUCES RAT SKELETAL MUSCLE DAMAGE CAUSED BY ISCHEMIA AND REPERFUSION显示文摘Acute interruption of arterial blood flow to the extremities is often associated with significant morbidity and mortality. Broad spectrum mitogenic and non mitogenic activities of FGFs inspired us to study its protecting effects on tissue injuries in ischemia reperfusion condition. We found that systemic administration of aFGF after reperfusion onset prevented severe skeletal muscle injuries. In rats treated with aKGF, the tissue edema was reduced significantly, the tissue viability was increased, and the muscle fibers contained more succinate dehydrogenase (SDH) and adenosine triphosphatasc (ATPase). The pathological results supported the concept of improved prevention with aFGF treatment. The possible tissue protection by aFGF may come from its ability to regulate the concentration of evtra- and intracellular calcium ion. Besides, it may moderate other Ca2+ dependent enzyme conversion processes. Also, it may take part in the vascular tone regulation under ischemia and reperfusion conditions. These | 傅小兵 Cuevas P. Gimenez-Gallego G 盛志勇 田惠民 | 1995 | Chinese Medical Journal1995，，3： | 6 |
| 3 | Determinants of percutaneous coronary intervention success in repeat chronic total occlusion procedures following an initial failed attempt显示文摘AIM To investigate the rates and determinants of success of repeat percutaneous coronary intervention(PCI) following an initial failed attempt at recanalising the chronic total occlusions(CTO) percutaneously.METHODS In 445 consecutive first attempt CTO-PCI procedures in our institution,procedural failure occurred in 149(33.5%). Sixty-four re-PCI procedures were performed in 58 patients(39%) all had a single CTO. Procedural and outcome data in the re-PCI population was entered into the institutional database. A retrospective analysis of clinical,angiographic and procedural data was performed. RESULTS Procedural success was achieved in 41(64%) procedures. Univariate analysis of clinical and angiographic characteristics showed that re-PCI success was associated with intravascular ultrasound(IVUS) guidance(19.5% vs 0%,P = 0.042),while failure was associated with severecalcification(30.4% vs 9.7%,P = 0.047) and a JCTO score > 3(56.5% vs 17.1% P = 0.003). Following multiple regression analysis the degree of lesion complexity(J-CTO score > 3),IVUS use,involvement of an experienced CTO operator and LAD CTO location were significant predictors of successful re-PCI. Overall the complication rate was low,with the only MACCE two periprocedural MI's neither of which required intervention. CONCLUSION Re-PCI substantially increases the overall success rate of CTO revascularization. Predictors of re-PCI success included the use of IVUS,the involvement of an experienced CTO operator in the repeat attempt and the location of the CTO. | Cecilia Cuevas Nicola Ryan Alicia Quirós Juan Gustavo Del Angel Nieves Gonzalo Pablo Salinas Pilar Jiménez-Quevedo Luis Nombela-Franco Ivan Nunez-Gil Antonio Fernandez-Ortiz Carlos Macaya Javier Escaned | 2017 | World Journal of Cardiology2017，9，4： | 5 |
| 4 | Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma显示文摘 | Paolo P. Provenzano Carlos Cuevas Amy E. Chang Vikas K. Goel Daniel D. Von Hoff Sunil R. Hingorani | 2012 | Cancer Cell2012，，： | 5 |
| 5 | ISCHEMIA AND REPERFUSION REDUCE THE ENDOGENOUS BASIC FIBROBLAST GROWTH FACTOR (bF GF) IN RATSKELETAL MUSCLES显示文摘Polyclonal antibodies directed against human recombinant basic fibroblast growth factor (bFGF) were used in immunohistochemical studies to localize this growth factor in normal and wounded rat skeletal muscles. bFGF immunoreactivity was found mainly in the extracellular matrix, primarily in the endomysium, including the heparin-containing basal lamina and also in the capillary basal membrane of both normal and wounded muscles, however the signal intensity was much stronger in normal muscles. After 4-hour ischemia, about 40% of skeletal muscle fibers lost their bFGF immunoreactivity. Muscles which experienced 4-hour ischemia and 24 reperfusion had only a weaker bFGF immunoreactivity. The pathological results supported the concept of destroyed cell connection and fiber necrosis in ischemia and reperfused muscles. The mechanisms involved in this reduced concentration of bFGF in wounded muscles included oxygen radical activation, inflammatory response and reduced secretion of endogenous bFGF. These results | 傅小兵 Cuevas P Gimenez-Gallego G 田惠民 盛志勇 | 1995 | Chinese Medical Journal1995，，9： | 3 |
| 6 | Preclinical evaluation of azathioprine plus buthionine sulfoximine in the treatment of human hepatocarcinoma and colon carcinoma显示文摘AIM: To evaluate the efficacy and the safety of azathioprine (AZA) and buthionine sulfoximine (BSO) bylocalized application into HepG2 tumor in vivo.METHODS: Different hepatoma and colon carcinoma cell lines (HepG2, HuH7, Chang liver, LoVo, RKO, SW-48, SW-480) were grown in minimal essencial medium supplemented with 10% fetal bovine serum and 1% antibiotic/antimycotic solution and maintained in a humidified 37 ℃ incubator with 5% CO2. These cells were pretreated with BSO for 24 h and then with AZA for different times. We examined the effects of this combination on some proteins and on cellular death. We also studied the eff icacy and the safety of AZA (6 mg/kg per day) and BSO (90 mg/kg per day) in HepG2 tumor growth in vivo using athymic mice. We measured safety by serological markers such as aminotransferases and creatine kinase.RESULTS: The in vitro studies revealed a new mechanism of action for the AZA plus BSO combination in the cancer cells compared with other thiopurines (6-mercaptopurine, 6-methylmercaptopurine, 6-thioguanine and 6-methylthioguanine) in combination with BSO. The cytotoxic effect of AZA plus BSO in HepG2 cells resulted from necroptosis induction in a mitochondrial-dependent manner. From kinetic studies we suggest that glutathione (GSH) depletion stimulates c-Jun amino-terminal kinase and Bax translocation in HepG2 cells with subsequent deregulation of mitochondria (cytochrome c release, loss of membrane potential), and proteolysis activation leading to loss of membrane integrity, release of lactate dehydrogenase and DNA degradation. Some of this biochemical and cellular changes could be reversed by N-acetylcysteine (a GSH replenisher). In vivo studies showed that HepG2 tumor growth was inhibited when AZA was combined with BSO.CONCLUSION: Our studies suggest that a combination of AZA plus BSO could be useful for localizedtreatment of hepatocellular carcinoma as in the currently used transarterial chemoembolization method. | Borja Hernández-Breijo Jorge Monserrat Sara Ramírez-Rubio Eva P Cuevas Diana Vara Inés Díaz-Laviada M Dolores Fernández-Moreno Irene D Román Javier P Gisbert Luis G Guijarro | 2011 | World Journal of Gastroenterology2011，17，34： | 2 |
| 7 | Nuptial gifts and female fecundity in the neotropical katydid Conocephalus ictus (Orthoptera: Tettigonidae)显示文摘一般来说,女健康极大地在给礼品的昆虫被增加。在纺织娘,这件结婚礼品由附件腺生产的一个凝胶状的团组成:spermatophylax,它被纳入两耳细颈瓶。在交配期间,新热带区的纺织娘 Conocephalus 冲击的男性转移被女性摄取的 spermatophylax。肥沃,生蛋的率和长寿在比在那些消费了 spermatophylax 的女性是更高的。另外,女感受性在交配以后关掉。女性们活跃地由用他们的前肢撞击他们并且离开移动拒绝了另外的男性。他们的倔强的时期持续了只要 17d。仅仅一些女性接受了第二交配并且一些天以后死了。在 C。冲击, spermatophylax 消费能为男性和女性是有益的。一方面,在 spermatophylax 的混合物或精液能阻止或推迟女性与对手交接,因此避免精子竞争。在另一方面,如此的混合物能改进 females’机会将增加他们的 lifespan 和肥沃。而且,处于生蛋的率的上升可以降低快速的 oviposition 引起的女 prereproductive 死亡的风险。在任何情况下,因为他们后代的数字增加,在生的女鸡蛋的增加可能也为男性是有益的。 | Isabel Ortiz-Jimenez Raul Cueva del Castillo | 2015 | Insect Science2015，22，1： | 2 |
| 8 | 孕妇使用选择性5-羟色氨重吸收抑制剂与新生儿停药综合征的关系:数据库资料分析 | Sanz E.J. De- las- Cuevas C. Kiuru A. 张剑萍 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，7： | 2 |
| 9 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 10 | Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy显示文摘Chimeric antigen receptor-based T-cell immunotherapy is a promising strategy for treatment of hematological malignant tumors;however,its efficacy towards solid cancer remains challenging.We therefore focused on developing nanobody-based CAR-T cells that treat the solid tumor.CD105 expression is upregulated on neoangiogenic endothelial and cancer cells.CD105 has been developed as a drug target.Here we show the generation of a CD105-specific nanobody,an anti-human CD105 CAR-T cells,by inserting the sequences for anti-CD105 nanobody-linked standard cassette genes into AAVS1 site using CRISPR/Cas9 technology.Co-culture with CD105+target cells led to the activation of anti-CD105 CAR-T cells that displayed the typically activated cytotoxic T-cell characters,ability to proliferate,the production of pro-inflammatory cytokines,and the specific killing efficacy against CD105+target cells in vitro.The in vivo treatment with anti-CD105 CAR-T cells significantly inhibited the growth of implanted CD105+tumors,reduced tumor weight,and prolonged the survival time of tumor-bearing NOD/SCID mice.Nanobody-based CAR-T cells can therefore function as an antitumor agent in human tumor xenograft models.Our findings determined that the strategy of nanobody-based CAR-T cells engineered by CRISPR/Cas9 system has a certain potential to treat solid tumor through targeting CD105 antigen. | Fengzhen Mo Siliang Duan Xiaobing Jiang Xiaomei Yang Xiaoqiong Hou Wei Shi Cueva Jumbo Juan Carlos Aiqun Liu Shihua Yin Wu Wang Hua Yao Zihang Yu Zhuoran Tang Shenxia Xie Ziqiang Ding Xinyue Zhao Bruce D.Hammock Xiaoling Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 2 |
| 11 | The MnSOD Ala16Val SNP: Relevance to human diseases and interaction with environmental factors显示文摘 | G. Bresciani I. B. M. Cruz J. A. de Paz M. J. Cuevas J. Gonzá lez-Gallego | 2013 | Free Radical Research2013，，10： | 2 |
| 12 | Sand attrition in conical spouted beds显示文摘A study was carried out on the attrition in conical spouted beds using two sands with different properties for several bed heights and gas flow rates. Furthermore, the influence of a draft tube was studied at ambient and high temperatures. The main objective was to acquire knowledge on the attrition of sand beds for biomass pyrolysis in a pilot plant provided with a conical spouted bed reactor. A first-order kinetic equation is proposed for sand attrition in a conical spouted bed at room temperature. The predicted attrition rate constant depends exponentially on excess air velocity over that for minimum spouting. Both the draft tube and temperature increase contribute to reduction of attrition. | Aranzazu R. Fernández-Akarregui Jon Makibar Isabel Alava Luis Diaz Fernando Cueva Roberto Aguado Gartzen Lopez Martin Olazar | 2012 | Particuology2012，10，5： | 2 |
| 13 | Heat transfer enhancement in oscillatory flows of newtonian and viscoe lastic fluids显示文摘 | Lambert A A Cuevas S del Rio J A | 2009 | International Journal of Heat and Mass Transfer2009，52，： | 1 |
| 14 | Sigma-1 receptor activation prevents intracellular calcium dys- regulation in cortical neurons during in vitro ischemia 显示文摘 | Katnik C Guerrero WR Pennypacker KR Herrera Y Cuevas J | 2005 | J Pharmacol Exp Ther2005，319，3： | 1 |
| 15 | Transition-metal profiles in a mulicrystalline silicon ingot 显示文摘 | Macdonald Daniel Cuevas Andres Kinomura A | 2005 | Applied Physics2005，97，3： | 1 |
| 16 | Comparative in vitro activitiy of moxifloxaein by E - test against streptococcus pyogenes 显示文摘 | Ambile - Cuevas CF Hermid - Esobedo C Vivar R | 2001 | Clin Infect Dis2001，32，： | 1 |
| 17 | An experimental and theoretical study of substituent efects on the redox properties of 2-[(R-phenyl)-amine]-l,4 naphthalenediones in acetonitrile显示文摘 | AGUILAR-MARTINEZ M CUEVAS G JIMENEZ-ESTRADA M | | 0，，： | 1 |
| 18 | Circle detection u- sing electro-magnetism optimization显示文摘 | Cuevas E Oliva D Zaldivar D | 2012 | Information Sci-ences2012，182，1： | 1 |
| 19 | Guideline adherence in management of stable chronic obstructive pulmonary disease显示文摘 | Roozbeh Sharif Christel R. Cuevas Yue Wang Mohit Arora Gulshan Sharma | 2013 | Respiratory Medicine2013，，7： | 1 |
| 20 | Dynamics of organic matter and nutrient return from litterfall in stands of ten tropical tree plantation species显示文摘 | Elvira Cuevas Ariel E. Lugo | 1998 | Forest Ecology and Management1998，，3： | 1 |
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